Vaccine development for Group B Neisseria meningitidis and Escherichia coli K1

B 组脑膜炎奈瑟菌和大肠杆菌 K1 的疫苗开发

• 批准号: 8553955
• 负责人: Rachel Schneerson
• 金额: $ 4.77万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553955
• 关键词: Antibiotic Therapy; Antibodies; Autoimmune Diseases; Development; Disease Outbreaks; Epidemic; Escherichia coli; Link; Meningitis; Meningococcal meningitis; Morbidity - disease rate; Neisseria meningitidis; Neonatal; Polysaccharides; Sialic Acids; Structure; Supportive care; Surface; Systemic infection; Work; kidney infection; mortality; vaccine development

No work was accomplished on this project this year. Vaccine development against group B meningococcal meningitis is complicated by its capsular polysaccharide (PSA), an a 2-8-linked poly-sialic acid that is identical to the surface saccharide of the E. coli K1 capsular polysaccharide and to host structures especially during development. Despite effective antibiotic and supportive therapy, the mortality and morbidity of systemic infections, especially of meningitis caused by group B meningococci and Escherichia coli K1, remain unacceptably high. Group B meningococci (GBM) continue to cause epidemics and outbreaks throughout the world and E. coli K1 is a major cause of neonatal meningitis and of kidney infections. The aim of this study is to examine evidence or the lack thereof of the association between PSA antibodies and autoimmune disease.

今年这个项目没有完成任何工作。 针对B群脑膜炎球菌脑膜炎的疫苗开发因其荚膜多糖（PSA）而复杂化，所述荚膜多糖是与E. coli K1荚膜多糖和宿主结构，特别是在发育过程中。尽管有有效的抗生素和支持治疗，但全身感染，特别是由B群脑膜炎球菌和大肠杆菌K1引起的脑膜炎的死亡率和发病率仍然高得令人无法接受。B群脑膜炎双球菌（GBM）在世界范围内持续引起流行和暴发，E.大肠杆菌K1是新生儿脑膜炎和肾脏感染的主要原因。本研究的目的是检查证据或缺乏PSA抗体和自身免疫性疾病之间的关联。

项目成果

Risk of adverse birth outcome after group B meningococcal disease: results from a Danish national cohort.

B 组脑膜炎球菌病后不良出生结局的风险：丹麦国家队列的结果。

• DOI: 10.1097/inf.0b013e31818c9049
• 发表时间: 2009
• 期刊: The Pediatric infectious disease journal
• 作者: Howitz,MichaelF;Simonsen,Jacob;Krause,TyraGrove;Robbins,JohnB;Schneerson,Rachel;Molbak,Kare;Miller,MarkA
• 通讯作者: Miller,MarkA