OTHER FUNCTIONS "DEVELOPMENT OF A UNI-DIRECTIONAL BRACHYTHERAPY DEVICE FOR THE T

其他功能“开发用于 T 的单向近距离治疗装置

• 批准号: 8557615
• 负责人: KRISTY PEREZ
• 金额: $ 99.9万
• 依托单位: CIVATECH ONCOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-28 至 2014-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8557615
• 关键词: American Cancer Society; Anatomy; Arteries; Brachytherapy; Breast; Bronchogenic Carcinoma; Cancer Patient; Chest wall structure; Clinic; Clinical; Communities; Contracts; Development; Devices; Disease; Dose; Exposure to; Female; Heart; I125 isotope; Localized Disease; Lung; Lung Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Metals; National Cancer Institute; Nerve; Non-Small-Cell Lung Carcinoma; Palladium 103; Patients; Phase; Publications; Radiation; Radiation therapy; Risk; Seeds; Shapes; Skin; Small Business Innovation Research Grant; Source; Structure; Testing; Tissues; Vicryl; Woman; advanced disease; alternative treatment; cancer therapy; clinical practice; design; meetings; men; prototype; seal

According to the American Cancer Society 220,000 men and women in the U.S. develop lung and bronchial cancer every year and 147,000 die of the disease. Of lung cancer patients, 85% present with non-small-cell lung cancer and 16.7% of these will present with localized disease. Note that lung cancer is very difficult to treat. The five year survival for localized disease is 52%, the five year survival for more advanced disease is less than 24%. At present, brachytherapy devices used for lung cancer treatment consist of metal I-125 or Cs-131 seeds, originally designed for prostate cancer, sewn to a bio-absorbable vicryl mesh. The device is not optimal for treating lung cancer. The device emits radiation in all directions and delivers radiation to otherwise healthy tissue. It is cumbersome to handle and difficult to shape to the patient¿s anatomy. Lung tumors are often located near critical structures sensitive to radiation exposure. Approximately 20% of patients who otherwise could be treated with lung brachytherapy are either not treated or prescribed alternative treatments due to the risk of radiation exposure to the arteries, nerves, the heart, the chest wall, the skin, and in female patients, the breasts. Those patients who are treated with the existing device are exposed to unnecessary radiation dose. CivaTech developed, with partial support from a Phase I SBIR contract from the National Cancer Institute, a prototype brachytherapy device specifically designed for lung cancer treatment that directions radiation therapy to diseased tissue only. This device, called the CivaSheet, is planar, uni-directional and partially bio-absorbable. CivaTech is seeking Phase II support to develop the prototype into a clinic ready device.

根据美国癌症协会的数据，美国每年有22万男性和女性患肺癌和支气管癌，14.7万人死于这种疾病。在肺癌患者中，85%表现为非小细胞肺癌，其中16.7%表现为局限性疾病。请注意，肺癌很难治疗。局部疾病的5年生存率为52%，晚期疾病的5年生存率低于24%。