Central Noradrenergic Neuron Subtype Development and Function

中枢去甲肾上腺素能神经元亚型的发育和功能

• 批准号: 8553802
• 负责人: Patricia Jensen
• 金额: $ 148.08万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553802
• 关键词: Affect; Alzheimer' s Disease; Anxiety; Attention; Attention deficit hyperactivity disorder; Behavior; Biological Models; Brain; Cells; Cellular Morphology; Desire for food; Development; Disease; Down Syndrome; Environmental Risk Factor; Genetic; Goals; Heterogeneity; Imagery; Knowledge; Learning; Location; Memory; Mental Depression; Moods; Mus; Nervous system structure; Neuraxis; Neurons; Neuropeptides; Norepinephrine; Parkinson Disease; Pattern; Peripheral Nervous System; Play; Population; Post-Traumatic Stress Disorders; Role; Series; Stress; Structure; base; critical period; molecular marker; nervous system disorder; noradrenergic; novel; recombinase; tool

Noradrenergic (NE) neurons, the cells of the nervous system that actively synthesize norepinephrine, play an essential role in circuits governing attention, mood, appetite, memory, anxiety and stress. In addition, NE neurons provide pivotal support for autonomic function in the peripheral nervous system. Consequently, abnormal function of NE neurons is implicated in a broad spectrum of neurological disorders such as depression, post-traumatic stress disorder (PTSD), attention deficit hyperactivity disorder (ADHD), Parkinsons disease, Alzheimers disease and Down syndrome. In several of these disorders there is evidence that unique subpopulations of NE neurons are selectively affected. Further heterogeneity among NE neurons is illustrated by their anatomical location, cell morphology, axonal projection pattern, neuropeptide expression and vulnerability to environmental factors. Mechanisms that determine such features are currently unknown, and no molecular markers that are capable of distinguishing physiologically relevant NE neuron subtypes have been identified. Such knowledge is central to understanding why select subpopulations of NE neurons are differentially susceptible to disease and environmental insult. To begin filling this knowledge gap, we are investigating the origin, development and function of genetically defined subsets of NE neurons in the mouse central nervous system through the application of a novel set of recombinase-based genetic tools.

去甲肾上腺素能（NE）神经元是神经系统中主动合成去甲肾上腺素的细胞，在控制注意力、情绪、食欲、记忆、焦虑和压力的回路中发挥重要作用。此外，NE神经元为周围神经系统中的自主神经功能提供关键支持。 因此，NE神经元的异常功能涉及广泛的神经障碍，例如抑郁症、创伤后应激障碍（PTSD）、注意力缺陷多动障碍（ADHD）、帕金森病、阿尔茨海默病和唐氏综合征。在这些疾病中，有证据表明NE神经元的独特亚群受到选择性影响。NE神经元的解剖位置、细胞形态、轴突投射模式、神经肽表达和对环境因素的脆弱性说明了NE神经元之间的进一步异质性。确定这些特征的机制目前尚不清楚，也没有能够区分生理相关NE神经元亚型的分子标记物。这些知识对于理解为什么NE神经元的选择亚群对疾病和环境损伤的敏感性不同至关重要。为了开始填补这一知识空白，我们正在调查的起源，发展和功能的遗传定义的NE神经元的子集在小鼠中枢神经系统通过应用一套新的重组酶为基础的遗传工具。