Exposure Science, Characterization, and Generation

受控暴露设施核心的总体目标是为人类研究提供能力 以及对吸入燃烧产生的颗粒物和气体的动物毒理学反应。 这一核心将主要提供技术支持、设施、管理和协调受控 为毒理学和人体临床研究提供暴露实验，并将提供技术建议 大气气溶胶特性、大气环境暴露评估的流行病学项目 颗粒和气体，以及环境空气污染物的源/受体关系。。燃烧尾气 支持毒理学和人类临床研究的暴露将在最近建造的和具有良好特征的 华盛顿大学诺斯莱克实验室的暴露设施。这次曝光 生成和表征活动将通过以下具体目标实现：1)生成相关的 燃烧尾气暴露大气；2：表征在每个过程中产生的颗粒和气体 3)改善暴露气氛，提高对柴油机废气毒性的认识。 这些修改将提供实验条件，允许对 生物系统。

The overall objective of the Controlled Exposure Facility core is to provide capabilities for the study of human and animal toxicological responses to inhalation exposures of combustion-generated particles and gases. This core will primarily provide technical support, facilities, management and coordination of controlled exposure experiments for the toxicology and human clinical studies, and will also provide technical advice to the epidemiology project on characterization of atmospheric aerosols, exposure assessment of airborne particles and gases, and source/receptor relationships of ambient air pollutants. . The combustion exhaust exposures in support of the toxicology and human clinical studies will take place in a recently built and wellcharacterized exposure facility in the Northlake Laboratory of the University of Washington. This exposure generation and characterization activity will be achieved via the following specific aims: 1) Generate relevant combustion exhaust exposure atmospheres; 2: Characterize particles and gases generated during each exposure; 3) Modify exposure atmospheres to enhance understanding of the toxicity of diesel exhaust. These modifications will provide experimental conditions that permit experimental evaluation of toxicity to biological systems.