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Pooled shRNA screens for target discoveries in cancer

Pooled shRNA screens for target discoveries in cancer
混合 shRNA 筛选癌症靶点发现
批准号：
8553186
负责人：
Ji Luo
金额：
$13.47万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8553186
关键词：
Cancer cell lineDependencyGenesGeneticGoalsHumanIntramural Research ProgramLibrariesMalignant NeoplasmsMethodsNormal CellPublishingResearch PersonnelResourcesTechnologycancer cellcost effectivesmall hairpin RNAtool

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英文摘要
BACKGROUNDRNAi has become a powerful genetic tool for dissecting genetic dependencies in cancer cells. We have developed methods and technologies to conduct rapid and cost-effective shRNA library screens to identify genetic dependencies in cancer cells.PURPOSEIn this project we will collaborate with other investigators (primarily in the NCI Intramural Program) to enable them to conduct shRNA screens in their cancer cell lines.SIGNIFICANT MATERIALS AND METHODSPooled shRNA library targeting most annotated human genes.FY2012 ACCOMPLISHMENTWe have initiated a number of shRNA screens in difference cancer cell lines and one such screen has been published already.
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