PROJECT 1

项目1

• 批准号: 8516177
• 负责人: Ming Chen Hammond
• 金额: $ 53.46万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8516177
• 关键词: Alternative Splicing; Binding Sites; Biochemical; Biological Assay; Cells; Chemicals; Data; Data Set; Event; Exons; Gene Expression Profile; Gene Mutation; Genes; Genetic Variation; Goals; Heterogeneous-Nuclear Ribonucleoproteins; Histones; Human; Human Genetics; In Vitro; Individual; Informatin; Link; Maps; Methods; Modeling; Molecular; Molecular Chaperones; Nuclear; Pattern; Phylogenetic Analysis; Play; Positioning Attribute; Proteins; RNA; RNA Binding; RNA Helicase; RNA Polymerase II; RNA Splicing; RNA annealing; Regulatory Element; Relative (related person); Reporter; Role; Site; Structure; Systems Biology; Testing; base; genetic variant; genome-wide; helicase; human disease; in vivo; mRNA Precursor

Summary Our overall project goal is to systematically link c/s-regulatory elements iri pre-mRNAs to RNA structural features that control alternative pre-mRNA splicing in human cells. While the role of pre-mRNA structure in control of splicing events has been studied for individual genes, a comprehensive understanding of the interplay of RNA structure with splicing control¿and its relation to genetic variation¿is not known for the human transcriptome.

摘要 我们的总体项目目标是系统地将c/S调节元件iri前-mRNAs与控制人类细胞中选择性前-mRNAs剪接的rna结构特征联系起来。虽然已经研究了前mRNA结构在单个基因剪接事件控制中的作用，但对于人类转录组来说，全面了解RNA结构与剪接控制的相互作用及其与遗传变异的关系尚不清楚。