PROJECT 1

项目1

• 批准号: 8539510
• 负责人: Ming Chen Hammond
• 金额: $ 49.26万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8539510
• 关键词: Alternative Splicing; Binding Sites; Biochemical; Biological Assay; Cells; Chemicals; Data; Data Set; Event; Exons; Gene Expression Profile; Gene Mutation; Genes; Genetic Variation; Goals; Heterogeneous-Nuclear Ribonucleoproteins; Histones; Human; Human Genetics; In Vitro; Individual; Informatin; Link; Maps; Methods; Modeling; Molecular; Molecular Chaperones; Nuclear; Pattern; Phylogenetic Analysis; Play; Positioning Attribute; Proteins; RNA; RNA Binding; RNA Helicase; RNA Polymerase II; RNA Splicing; RNA annealing; Regulatory Element; Relative (related person); Reporter; Role; Site; Structure; Systems Biology; Testing; base; genetic variant; genome-wide; helicase; human disease; in vivo; mRNA Precursor

Summary Our overall project goal is to systematically link c/s-regulatory elements iri pre-mRNAs to RNA structural features that control alternative pre-mRNA splicing in human cells. While the role of pre-mRNA structure in control of splicing events has been studied for individual genes, a comprehensive understanding of the interplay of RNA structure with splicing control¿and its relation to genetic variation¿is not known for the human transcriptome.

概括 我们的总体项目目标是将顺式/顺式调节元件 iri pre-mRNA 与控制人类细胞中选择性 pre-mRNA 剪接的 RNA 结构特征系统地联系起来。虽然已经针对单个基因研究了前 mRNA 结构在控制剪接事件中的作用，但对于人类转录组，对 RNA 结构与剪接控制的相互作用及其与遗传变异的关系的全面理解尚不清楚。