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Cell Processing and Cell Distribution Core

细胞处理和细胞分配核心

基本信息

批准号：
8269987
负责人：
Robert Lowsky
金额：
$ 26.23万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8269987
关键词：
Affect Air Blood Blood Component Removal Blood specimen Bone Marrow Transplantation CD3 Antigens CD34 gene CD8B1 gene Cell Therapy Cell Transplantation Cell physiology Cells Climate Clinical Clinical Research Computers and Advanced Instrumentation Cryopreservation Dependence Development Documentation Donor person Drug or chemical Tissue Distribution Electronics Environmental Monitoring Equipment Gases Granulocyte Colony-Stimulating Factor Harvest Hematopoietic Hematopoietic stem cells Hospitals Hour Human Immunotherapy Incubators Infusion procedures Investigation Kidney Laboratories Link Liquid substance Marrow Medical Memory Monitor Nitrogen Patients Performance Preparation Procedures Process Production Program Research Project Grants Quarantine Reading Records Research Personnel Research Support Safety Sampling Security Specific qualifier value Stem cell transplant System T memory cell T-Lymphocyte Technology Testing Therapeutic Time Tissue Banking Tissue Banks Tissue Sample Tissues Transplant Recipients Transplantation United States Public Health Service Validation base cell preparation cellular development design follow-up instrumentation programs sample collection square foot

项目摘要

Core B: The Cell Processing and Cell Distribution Core will provide essential cell processing and cell distribution support for Program Project Investigators. Operating through the Stanford Blood and Marrow Transplant Program's Cellular Therapeutics and Transplantation (SCTT) Laboratory, Core B will be responsible for donor preparation for cell harvesting including granulocyte-colony stimulating factor administration and apheresis, as well as, all aspects of hematopoietic cell processing which include manipulation and storage of products, release testing, process documentation and process validation. The laboratory will employ GMP in the preparation of hematopoietic cells for Projects 1 and 2. Core B will also establish a tissue bank for transplant recipient and donor samples and will manage the distribution of these samples to investigators for Projects 1, 2 and 4.

核心B：细胞处理和细胞分配核心将为项目调查员提供基本的细胞处理和细胞分配支持。通过斯坦福血液和骨髓移植项目的细胞治疗和移植（SCTT）实验室，Core B将负责供体准备细胞采集，包括粒细胞集落刺激因子管理和分离，以及造血细胞处理的所有方面，包括产品的操作和储存，释放测试，工艺文件和工艺验证。项目1和项目2的造血细胞制备将采用GMP。B中心还将为移植受体和供体样本建立一个组织库，并负责将这些样本分发给项目1、2和4的研究人员。