Dissecting Innate Immunity to Helminth Parasites

剖析对蠕虫寄生虫的先天免疫

• 批准号: 8215616
• 负责人: Mark Christopher Siracusa
• 金额: $ 5.39万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-05 至 2013-03-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8215616
• 关键词: Address; Allergens; Allergic Disease; Antigen-Presenting Cells; Antigens; Asthma; B Cell Proliferation; B-Cell Activation; B-Lymphocytes; Basophils; Bromodeoxyuridine; CD4 Positive T Lymphocytes; Cell Communication; Cell Differentiation process; Cell Line; Cell physiology; Cells; Coculture Techniques; Coupled; Data; Developed Countries; Development; Enzyme-Linked Immunosorbent Assay; Exposure to; Flow Cytometry; Frequencies; Gene Expression Profiling; Goblet Cells; Helminth Antigens; Helminths; Homing; Hour; Hyperplasia; Hypersensitivity; Immune; Immune response; Immunity; Immunoglobulin Class Switching; In Vitro; Individual; Infection; Inflammation; Inflammatory Response; Injection of therapeutic agent; Interleukin-13; Interleukin-4; Interleukin-5; Interleukin-9; Intestines; Kinetics; Laboratories; Lymphocyte; MHC Class II Genes; Mediating; Modeling; Molecular; Monitor; Monoclonal Antibodies; Mucous body substance; Mus; Natural Immunity; Nematoda; Parasites; Pathway interactions; Play; Population; Prevalence; Production; Proliferating; Property; Protocols documentation; Recombinants; Recruitment Activity; Regulation; Role; STAT6 gene; Schistosoma mansoni; Signal Transduction; Skin; Smooth Muscle; Soil; Specific qualifier value; Staining method; Stains; Stromal Cells; Surface; System; TNFRSF5 gene; TNFSF5 gene; Testing; Th2 Cells; Time; Trichuris; base; cell type; chemokine; chemokine receptor; cytokine; egg; eosinophil; human TSLP protein; in vivo; lymph nodes; mouse model; pandemic disease; receptor; response; tissue repair; tool; trafficking; transcription factor

DESCRIPTION (provided by applicant): Th2 cytokine responses are required for immunity to helminth parasites and are also responsible for the detrimental inflammation associated with allergies and asthma. Given the global prevalence of soil transmitted helminth infections, currently estimated at two billion individuals worldwide, coupled with the pandemic of allergic diseases in industrialized countries, it is critical to gain a better understanding of the pathways that control Th2 cytokine-mediated immunity and inflammation. Despite significant developments in our understanding of the pathways that control the differentiation and regulation of Th2 immunity, the innate immune cells that recognize helminth- or allergen-derived antigens and present them to naive CD4+ T cells remain poorly defined. The aims of this proposal are directed at better understand those cells and mechanisms.

描述(由申请人提供)：Th2细胞因子反应是对蠕虫寄生虫免疫所必需的，也是与过敏和哮喘相关的有害炎症的原因。鉴于土壤传播蠕虫感染的全球流行，目前估计全世界有20亿人，加上工业化国家的过敏性疾病大流行，关键是更好地了解控制Th2细胞因子介导的免疫和炎症的途径。尽管我们对控制Th2免疫分化和调节的途径的了解取得了重大进展，但识别蠕虫或过敏原来源的抗原并将其呈递给初始的CD4+T细胞的先天免疫细胞仍然缺乏明确的定义。这项提议的目的是为了更好地了解这些细胞和机制。