Dissecting Innate Immunity to Helminth Parasites

描述（由申请人提供）：Th2细胞因子应答是对蠕虫寄生虫免疫所必需的，也是与过敏和哮喘相关的有害炎症的原因。鉴于土壤传播的蠕虫感染的全球流行，目前估计全球有20亿人，加上工业化国家过敏性疾病的流行，更好地了解控制Th2细胞介导的免疫和炎症的途径至关重要。尽管我们对控制Th2免疫的分化和调节的途径的理解有了重大进展，但识别蠕虫或过敏原衍生抗原并将其呈递给幼稚CD4+ T细胞的先天免疫细胞仍然定义不清。这项建议的目的是为了更好地了解这些细胞和机制。

DESCRIPTION (provided by applicant): Th2 cytokine responses are required for immunity to helminth parasites and are also responsible for the detrimental inflammation associated with allergies and asthma. Given the global prevalence of soil transmitted helminth infections, currently estimated at two billion individuals worldwide, coupled with the pandemic of allergic diseases in industrialized countries, it is critical to gain a better understanding of the pathways that control Th2 cytokine-mediated immunity and inflammation. Despite significant developments in our understanding of the pathways that control the differentiation and regulation of Th2 immunity, the innate immune cells that recognize helminth- or allergen-derived antigens and present them to naive CD4+ T cells remain poorly defined. The aims of this proposal are directed at better understand those cells and mechanisms.