How isomiRs expand the microRNA functional repertoire in affecting gene expression

MicroRNAs的功能是基因表达的调节。人们逐渐意识到，microRNAs经常被表达为具有微妙不同序列的变体。我们在这里发现，一种重要的与癌症相关的microRNA miR-222的变异促进了表达它们的细胞行为的差异。这项工作试图了解microRNA变异是如何赋予细胞这种特性的，识别miR-222变异调控的基因，并检查microRNA变异导致癌症的广泛性。

MicroRNAs function as regulators of gene expression. It is becoming appreciated that microRNAs are frequently expressed as variants with subtly different sequences. We find here that variation in one important cancer-associated microRNA, miR-222, promotes differences in the behaviour of cells expressing them. This work seeks to understand how microRNA variation confers such properties to cells, to identify the genes miR-222 variants regulate, and to examine how widespread it is that microRNA variation contributes to cancer.