Targets of epithelial microRNAs

上皮 microRNA 的靶标

• 批准号: nhmrc : 1034633
• 负责人: Dr Cameron Bracken
• 金额: $ 37.06万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targets-epithelial-micrornas/110928
• 关键词: Targets; epithelial; microRNAs

MicroRNAs are small molecules that modulate the expression of most genes and so affect nearly every biological process and pathology although, they were only discovered in humans less than 10 years ago. The bottleneck in discovering the functions of miRNAs is in identifying their molecular targets, the majority of which remain unknown. We aim to comprehensively identify direct target genes of epithelial-specific microRNAs and to confirm a number of them by gene target validation approaches.

MicroRNA是一种小分子，可以调节大多数基因的表达，从而影响几乎所有的生物学过程和病理学，尽管它们在不到10年前才在人类中发现。发现miRNAs功能的瓶颈在于鉴定它们的分子靶点，其中大部分仍然未知。我们的目标是全面识别上皮特异性microRNA的直接靶基因，并通过基因靶点验证方法确认其中一些基因。