Management of Insomnia in Cancer Patients

癌症患者失眠的治疗

基本信息

  • 批准号:
    7923095
  • 负责人:
  • 金额:
    $ 13.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-09-26 至 2013-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Overview and Public Health Relevance: Oxana Palesh, Ph.D., a clinical psychologist, is applying for a career development award to expand her research skills and become an independent investigator in cancer control. Her long-term research objective is to reduce insomnia and insomnia symptoms in cancer patients and cancer survivors, groups with a high prevalence of these problems. In fact, sleep problems were reported by 70% of 330 breast cancer patients in a recent study by Dr. Palesh. Dr. Palesh's Career Development Plan builds upon a strong research background obtained at Stanford and the U of Rochester by enhancing specific measurable knowledge and skills in four areas: 1) cancer treatment and control, 2) the conduct of multi-center trials, 3) insomnia assessment and treatment, and 4) transitioning to an independent research career. Her primary mentor, Gary Morrow, Ph.D., has been a leader in cancer control for 30 years. He will contribute expertise in cancer and side effect management and in clinical trial design and analysis. Dr. Palesh's co-mentors also have outstanding experience in training researchers. Joseph Roscoe, Ph.D., will contribute expertise in behavioral research and cancer. Thomas Roth, Ph.D., an internationally recognized expert, will provide in-depth training in sleep research and treatment of insomnia. They are assisted by an Advisory Board of experts in cancer treatment, insomnia research, psychopharmacology and biostatistics. Research Plan: The proposed RCT, based on well established theoretical principles, expands promising preliminary data showing that both pharmacologic and behavioral interventions can improve insomnia. The two approaches will be compared with standard care in a 4 arm (Drug: yes/no; Behavioral Treatment: yes/no) randomized clinical trial of 60 breast cancer patients receiving chemotherapy. The primary goal is to provide preliminary data and effect size estimates for an R01 application to confirm results. These results will clarify the role of insomnia in the experiences of cancer patients undergoing treatment, inform potential strategies for interventions in these patients, and position Dr. Palesh, in combination with the training provided by this award, to successfully transition to a career as an independent investigator and leader in cancer control science.
描述(申请人提供):概述和公共卫生相关性:临床心理学家Oxana Palesh博士正在申请职业发展奖,以扩大她的研究技能,并成为癌症控制领域的独立调查员。她的长期研究目标是减少癌症患者和癌症幸存者的失眠和失眠症状,这些问题的发生率很高。事实上,在Palesh博士最近的一项研究中,330名乳腺癌患者中有70%的人报告了睡眠问题。Palesh博士的职业发展计划建立在斯坦福大学和罗彻斯特大学获得的强大研究背景的基础上,通过在四个领域加强具体的可测量的知识和技能:1)癌症治疗和控制,2)进行多中心试验,3)失眠评估和治疗,以及4)过渡到独立的研究生涯。她的主要导师,加里·莫罗博士,30年来一直是癌症控制领域的领导者。他将在癌症和副作用管理以及临床试验设计和分析方面贡献专业知识。佩雷什博士的联合导师在培训研究人员方面也拥有出色的经验。约瑟夫·罗斯科博士将在行为研究和癌症方面贡献专业知识。国际公认的专家Thomas Roth博士将在睡眠研究和失眠治疗方面提供深入培训。他们得到了癌症治疗、失眠研究、精神药理学和生物统计学专家咨询委员会的协助。研究计划:建议的随机对照试验以已确立的理论原则为基础,扩展了有希望的初步数据,表明药物和行为干预都可以改善失眠。在对60名接受化疗的乳腺癌患者进行的4组随机临床试验中(药物:是/否;行为治疗:是/否),这两种方法将与标准护理进行比较。主要目标是为R01应用程序提供初步数据和效果大小估计,以确认结果。这些结果将阐明失眠在癌症患者治疗中的作用,为这些患者提供潜在的干预策略,并使Palesh博士与该奖项提供的培训相结合,成功过渡到癌症控制科学领域的独立研究员和领导者的职业生涯。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Oxana G Palesh其他文献

Oxana G Palesh的其他文献

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{{ truncateString('Oxana G Palesh', 18)}}的其他基金

Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)
乳腺癌幸存者的超长期神经认知结果(ProbC2)
  • 批准号:
    10558447
  • 财政年份:
    2022
  • 资助金额:
    $ 13.58万
  • 项目类别:
Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)
乳腺癌幸存者的超长期神经认知结果(ProbC2)
  • 批准号:
    10643569
  • 财政年份:
    2022
  • 资助金额:
    $ 13.58万
  • 项目类别:
Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia
短期行为疗法治疗癌症相关失眠的多中心随机对照试验
  • 批准号:
    10642316
  • 财政年份:
    2022
  • 资助金额:
    $ 13.58万
  • 项目类别:
Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia
短期行为疗法治疗癌症相关失眠的多中心随机对照试验
  • 批准号:
    10591478
  • 财政年份:
    2022
  • 资助金额:
    $ 13.58万
  • 项目类别:
Multicenter Randomized Controlled Trial of Brief Behavioral Therapy for Cancer Related Insomnia
短期行为疗法治疗癌症相关失眠的多中心随机对照试验
  • 批准号:
    9916223
  • 财政年份:
    2020
  • 资助金额:
    $ 13.58万
  • 项目类别:
Efficacy of Brief Behavioral Therapy for Cancer-Related Insomnia in Reducing Headache Burden: Exploring Patient Phenotypes and Predictors of Response
简短行为疗法治疗癌症相关失眠在减轻头痛负担方面的功效:探索患者表型和反应预测因子
  • 批准号:
    10302033
  • 财政年份:
    2020
  • 资助金额:
    $ 13.58万
  • 项目类别:
Brief Behavioral Intervention for Insomnia During Chemotherapy
化疗期间失眠的简短行为干预
  • 批准号:
    8720244
  • 财政年份:
    2014
  • 资助金额:
    $ 13.58万
  • 项目类别:
Brief Behavioral Intervention for Insomnia During Chemotherapy
化疗期间失眠的简短行为干预
  • 批准号:
    9276643
  • 财政年份:
    2014
  • 资助金额:
    $ 13.58万
  • 项目类别:
Management of Insomnia in Cancer Patients
癌症患者失眠的治疗
  • 批准号:
    7694412
  • 财政年份:
    2008
  • 资助金额:
    $ 13.58万
  • 项目类别:
Management of Insomnia in Cancer Patients
癌症患者失眠的治疗
  • 批准号:
    8137044
  • 财政年份:
    2008
  • 资助金额:
    $ 13.58万
  • 项目类别:

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