Management of Insomnia in Cancer Patients

癌症患者失眠的治疗

• 批准号: 7694412
• 负责人: Oxana G Palesh
• 金额: $ 13.58万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7694412
• 关键词: Acute; Adverse effects; Affect; Area; Award; Behavior Control; Behavior Therapy; Behavioral Research; Biometry; Cancer Center; Cancer Control; Cancer Patient; Cancer Survivor; Chronic Disease; Chronic Insomnia; Clinical; Clinical Trials; Clinical Trials Design; Community Clinical Oncology Program; Controlled Clinical Trials; Data; Development; Development Plans; Distress; Doctor of Philosophy; Equipment and supply inventories; Fatigue; Feedback; Female Breast Carcinoma; General Population; Glucose; Goals; High Prevalence; Incidence; Intervention; K-Series Research Career Programs; Knowledge; Link; Malignant Neoplasms; Measurable; Measures; Medical; Memory; Mentors; Metabolic; Modafinil; Modeling; Needs Assessment; Outcome; Patients; Performance; Pharmaceutical Preparations; Pilot Projects; Placebos; Positioning Attribute; Psychologist; Psychopharmacology; Quality of life; Radiation therapy; Randomized; Randomized Clinical Trials; Regulation; Relative (related person); Reporting; Research; Research Personnel; Role; Schedule; Severities; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Specific qualifier value; Stimulus; Surveys; Symptoms; Time; Training; Universities; Upper arm; Wakefulness; Work; base; cancer diagnosis; cancer therapy; career; career development; chemotherapy; cognitive behavior therapy; design; disturbance in affect; experience; falls; gastrointestinal; immune function; improved; malignant breast neoplasm; mood regulation; programs; prospective; public health relevance; skills; sleep regulation; standard care

DESCRIPTION (provided by applicant): Overview and Public Health Relevance: Oxana Palesh, Ph.D., a clinical psychologist, is applying for a career development award to expand her research skills and become an independent investigator in cancer control. Her long-term research objective is to reduce insomnia and insomnia symptoms in cancer patients and cancer survivors, groups with a high prevalence of these problems. In fact, sleep problems were reported by 70% of 330 breast cancer patients in a recent study by Dr. Palesh. Dr. Palesh's Career Development Plan builds upon a strong research background obtained at Stanford and the U of Rochester by enhancing specific measurable knowledge and skills in four areas: 1) cancer treatment and control, 2) the conduct of multi-center trials, 3) insomnia assessment and treatment, and 4) transitioning to an independent research career. Her primary mentor, Gary Morrow, Ph.D., has been a leader in cancer control for 30 years. He will contribute expertise in cancer and side effect management and in clinical trial design and analysis. Dr. Palesh's co-mentors also have outstanding experience in training researchers. Joseph Roscoe, Ph.D., will contribute expertise in behavioral research and cancer. Thomas Roth, Ph.D., an internationally recognized expert, will provide in-depth training in sleep research and treatment of insomnia. They are assisted by an Advisory Board of experts in cancer treatment, insomnia research, psychopharmacology and biostatistics. Research Plan: The proposed RCT, based on well established theoretical principles, expands promising preliminary data showing that both pharmacologic and behavioral interventions can improve insomnia. The two approaches will be compared with standard care in a 4 arm (Drug: yes/no; Behavioral Treatment: yes/no) randomized clinical trial of 60 breast cancer patients receiving chemotherapy. The primary goal is to provide preliminary data and effect size estimates for an R01 application to confirm results. These results will clarify the role of insomnia in the experiences of cancer patients undergoing treatment, inform potential strategies for interventions in these patients, and position Dr. Palesh, in combination with the training provided by this award, to successfully transition to a career as an independent investigator and leader in cancer control science.

描述（由申请人提供）：概述和公共卫生相关性：Oxana Palesh 博士是一名临床心理学家，正在申请职业发展奖，以扩展她的研究技能并成为癌症控制领域的独立研究者。她的长期研究目标是减少癌症患者和癌症幸存者（这些问题的患病率较高的群体）的失眠和失眠症状。事实上，Palesh 博士最近的一项研究显示，330 名乳腺癌患者中有 70% 的人存在睡眠问题。 Palesh 博士的职业发展计划建立在斯坦福大学和罗彻斯特大学强大的研究背景之上，通过增强四个领域的具体可衡量知识和技能：1) 癌症治疗和控制，2) 进行多中心试验，3) 失眠评估和治疗，以及 4) 过渡到独立研究职业。她的主要导师 Gary Morrow 博士 30 年来一直是癌症控制领域的领导者。他将贡献癌症和副作用管理以及临床试验设计和分析方面的专业知识。帕莱什博士的共同导师在培训研究人员方面也拥有杰出的经验。 Joseph Roscoe 博士将贡献行为研究和癌症方面的专业知识。国际公认的专家Thomas Roth博士将提供睡眠研究和失眠治疗方面的深入培训。他们得到癌症治疗、失眠研究、精神药理学和生物统计学专家咨询委员会的协助。研究计划：拟议的随机对照试验基于既定的理论原理，扩展了有希望的初步数据，表明药物和行为干预都可以改善失眠。这两种方法将在一项 4 臂（药物：是/否；行为治疗：是/否）随机临床试验中对 60 名接受化疗的乳腺癌患者进行比较。主要目标是为 R01 应用提供初步数据和效应大小估计以确认结果。这些结果将阐明失眠在接受治疗的癌症患者经历中的作用，为这些患者的潜在干预策略提供信息，并使 Palesh 博士结合该奖项提供的培训，成功过渡到作为癌症控制科学领域的独立研究者和领导者的职业生涯。