Validation & Pathology Core

验证

• 批准号: 8244103
• 负责人: KENNETH K WANG
• 金额: $ 14.76万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8244103
• 关键词: Adenocarcinoma; Affinity; Barrett Esophagus; Binding; Biopsy; Clinical; Clinical Investigator; Clinical Research; Databases; Development; Dysplasia; Esophageal; Evaluation; Excision; Fluorescence; Gastroenterology; Genes; Genomics; Histopathology; Human Resources; Image; Label; Methods; Molecular Biology; Pathologist; Pathology; Peptides; Phase; Pilot Projects; Procedures; Recruitment Activity; Research; Research Project Grants; Research Support; Resolution; Role; Screening for cancer; Services; Specimen; Specimen Handling; Tissues; Ultrasonography; Validation; design; experience; fluorescence imaging; gastrointestinal; human subject; millimeter; novel; validation studies

The Validation & Pathology Core consists of personnel with expertise in clinical gastroenterology, advanced procedures (endoscopic mucosal resection, endoscopic ultrasound), specimen processing, molecular biology, and pathology. Core personnel have many years experience in validation methods. The specific role of this BETRNet Specialized Research Rescource (Core) is to support the Research Center in the design and analysis of validation studies for the binding activity of fluorescent-labeled peptides to high-grade dysplasia and early adenocarcinoma for imaging in Barrett's esophagus. This Core will also support the three Primary Research Projects, developmental (Pilot) projects, cross-BETRNet projects, and other cross-BETRNet activities by providing methods and services for pathological evaluation of tissue specimens, including EMR and biopsy.

验证和病理学核心由具有临床胃肠病学、高级程序（内镜粘膜切除术、内镜超声）、标本处理、分子生物学和病理学专业知识的人员组成。核心人员在验证方法方面具有多年经验。BETRNet Specialized Research Rescent（核心）的具体作用是支持研究中心设计和分析荧光标记肽与Barrett食管中高度异型增生和早期腺癌成像的结合活性的验证研究。该核心还将支持三个主要研究项目，发展（试点）项目，跨BETRNet项目和其他跨BETRNet活动，提供组织标本病理学评估的方法和服务，包括EMR和活检。