Novel Method of Surveillance in Barrett's Esophagus

巴雷特食管监测新方法

基本信息

  • 批准号:
    7250308
  • 负责人:
  • 金额:
    $ 16.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-04-17 至 2009-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Barrett's esophagus is felt to be the precursor lesion to esophageal adenocarcinoma which is the most rapidly increasing cancer in males. Clinical management decisions concerning this condition are based on biopsies of the Barrett's mucosa which are difficult to adequately obtain and interpret, costly to examine histologically, and often miss lesions of significance. The use of exfoliated cells from Barrett's esophagus collected with brush cytology has the potential to rapidly assess its malignant potential. We propose to investigate two novel methods to assess exfoliated cells to increase the sensitivity for malignant changes. It is our hypothesis that either digital image analysis (DIA) or fluorescent in situ hybridization (FISH) performed on exfoliated cells will be able to predict cancer development in Barrett's esophagus. We have demonstrated that both correlate well with histology from surveillance biopsies with FISH being significantly superior to DIA. This was done using an investigational set of twelve probes that targeted multiple important loci for cancer progression in Barrett's esophagus. We have taken this information to select four very targeted loci that we believe should allow us to develop a high-throughput test to determine cancer risk from exfoliated cells from Barrett's esophagus. Our primary aim will be to test this novel 4 probe FISH test against DIA in cytology specimens using the results of histology from surveillance biopsy for our reference. This will be accomplished by performing FISH and DIA on cytological specimens from patients with known Barrett's esophagus. A secondary aim will be to determine if cytological collection devices that acquire significantly different numbers of exfoliated cells will yield different results using FISH or DIA. Commercially available cytological brushes can vary as much as 6-fold in their ability to collect exfoliated cells. We have developed a novel cytology net that can acquire five times as many cells as the brushes. We propose to randomize the type cytology collection device used to collect the exfoliated cells to determine if this affects the results of DIA or FISH. The results of this study can potentially change the method by which physicians can evaluate the cancer risk of patients with Barrett's esophagus. It is hoped that by using cytology assessed with FISH or DIA, better information of cancer risk can be obtained so that patients can have cancers detected earlier or be treated to prevent cancer in order to decrease esophageal cancer related deaths. This is an innovative method by which a physician can diagnose hidden areas of cancer within patients who are at a high risk of developing esophageal cancer.
描述(由申请方提供):Barrett食管被认为是食管腺癌的前驱病变,食管腺癌是男性中增长最快的癌症。关于这种情况的临床管理决策是基于巴雷特粘膜活检,这是很难充分获得和解释,昂贵的组织学检查,往往错过病变的意义。使用刷检细胞学收集的Barrett食管脱落细胞有可能快速评估其恶性潜力。我们建议研究两种新的方法来评估脱落细胞,以增加恶性变化的敏感性。我们的假设是,对脱落细胞进行数字图像分析(DIA)或荧光原位杂交(FISH)将能够预测Barrett食管中的癌症发展。我们已经证明,两者都与监测活检的组织学相关,FISH明显上级于DIA。这是使用一组12个探针的研究来完成的,这些探针靶向巴雷特食管中癌症进展的多个重要位点。我们利用这些信息选择了四个非常有针对性的位点,我们相信这将使我们能够开发一种高通量测试,以确定巴雷特食管脱落细胞的癌症风险。我们的主要目的是利用监测活检的组织学结果作为参考,在细胞学标本中测试这种新的4探针FISH检测对DIA的影响。这将通过对已知患有Barrett食管的患者的细胞学标本进行FISH和DIA来完成。第二个目的是确定采集脱落细胞数量显著不同的细胞学采集装置是否会使用FISH或DIA产生不同的结果。市售的细胞学刷在收集脱落细胞的能力上可以变化多达6倍。我们已经开发出一种新型的细胞学网,它可以获得五倍于刷子的细胞。我们建议随机化用于收集脱落细胞的细胞学收集装置的类型,以确定这是否影响DIA或FISH的结果。这项研究的结果可能会改变医生评估巴雷特食管患者癌症风险的方法。希望通过使用FISH或DIA评估的细胞学,可以获得更好的癌症风险信息,以便患者可以早期发现癌症或进行治疗以预防癌症,从而减少食管癌相关死亡。这是一种创新的方法,通过这种方法,医生可以诊断出食管癌高危患者体内隐藏的癌症区域。

项目成果

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KENNETH K WANG其他文献

KENNETH K WANG的其他文献

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{{ truncateString('KENNETH K WANG', 18)}}的其他基金

Validation & Pathology Core
验证
  • 批准号:
    8555335
  • 财政年份:
    2011
  • 资助金额:
    $ 16.08万
  • 项目类别:
Validation & Pathology Core
验证
  • 批准号:
    8244103
  • 财政年份:
    2011
  • 资助金额:
    $ 16.08万
  • 项目类别:
Novel Method of Surveillance in Barrett's Esophagus
巴雷特食管监测新方法
  • 批准号:
    7408097
  • 财政年份:
    2007
  • 资助金额:
    $ 16.08万
  • 项目类别:
Endoscopic Therapy of Early Cancer in Barretts Esophagus
Barretts 食管早期癌的内镜治疗
  • 批准号:
    6969891
  • 财政年份:
    2005
  • 资助金额:
    $ 16.08万
  • 项目类别:
Endoscopic Therapy of Early Cancer in Barretts Esophagus
Barretts 食管早期癌的内镜治疗
  • 批准号:
    7648125
  • 财政年份:
    2005
  • 资助金额:
    $ 16.08万
  • 项目类别:
Endoscopic Therapy of Early Cancer in Barretts Esophagus
Barretts 食管早期癌的内镜治疗
  • 批准号:
    7123421
  • 财政年份:
    2005
  • 资助金额:
    $ 16.08万
  • 项目类别:
Endoscopic Therapy of Early Cancer in Barretts Esophagus
Barretts 食管早期癌的内镜治疗
  • 批准号:
    7234009
  • 财政年份:
    2005
  • 资助金额:
    $ 16.08万
  • 项目类别:
Endoscopic Therapy of Early Cancer in Barretts Esophagus
Barretts 食管早期癌的内镜治疗
  • 批准号:
    7468433
  • 财政年份:
    2005
  • 资助金额:
    $ 16.08万
  • 项目类别:
Biomarkers in Phototherapy of Barrett's Esophagus
巴雷特食管光疗中的生物标志物
  • 批准号:
    6667258
  • 财政年份:
    2002
  • 资助金额:
    $ 16.08万
  • 项目类别:
Biomarkers in Phototherapy of Barrett's Esophagus
巴雷特食管光疗中的生物标志物
  • 批准号:
    6531392
  • 财政年份:
    2002
  • 资助金额:
    $ 16.08万
  • 项目类别:

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