MOUSE MODEL RESOURSE

小鼠模型资源

• 批准号: 8288288
• 负责人: LEAH RAE B DONAHUE
• 金额: $ 30.3万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8288288
• 关键词: Area; Biological; Biology; Breeding; Cancer Center; Charge; Chromosome Mapping; Chromosome abnormality; Collection; Consomic Strain; Cryopreservation; DNA; Data; Databases; Economics; Electronics; Embryo; Engineering; Genetic; Genome; Germ Cells; Grant; Human Resources; Inbred Strain; Inbreeding; Individual; Insurance; Knowledge; Life; Maintenance; Mouse Strains; Mus; Mutation; Procedures; Publications; Recombinants; Research Personnel; Resources; Science; Scientist; Services; congenic; experience; functional genomics; genetic resource; member; mouse model; mutant; phenome; programs; repository; reproductive; transmission process

The Mouse Models Resource (MMR) provides TJL Cancer Center investigators with access to approximately 800 of the 2,900 publicly available strains available from TJL's Genetic Resource Repository. The MMR also provides information about these strains, and the expertise of scientists in the Genetic Resource Program. The live Resource, together with Resource strains available from the Cryopreservation Resource comprises the Genetic Resource Repository and is the largest single collection of genetically defined mouse strains anywhere in the world. The Mouse Models Resource provides TJL Cancer Center members with small numbers of mice from the Repository free of charge. Cancer Center members can obtain breeding pairs and small numbers of mutants and controls from mutant strains, or individual mice from strain panels. Cancer Center members add value to the strains by further characterizing them; this scientific information is added to the strain information database from resulting publications or by electronic transmission directly into the Mouse Phenome Database for strain panels. The Resource contains mouse strains carrying spontaneous, induced, and genetically engineered mutations; mice with chromosome aberrations; and special inbred strains and strain panels, including wild-derived inbred, congenic, Recombinant Inbred (Rl), and consomic strains. For insurance against loss and economic management of very low demand strains, all strains are cryopreserved as embryos or gametes through the Reproductive Sciences program, and DNA from most strains is available through the Mouse DNA Resource in Genome Sciences. Genetic Resource Technical Information Scientists gather, curate, and maintain the operational and scientific information about these strains. Mouse Models Resource personnel provide genetic expertise and advice, and colony maintenance advice, including special husbandry needs and biological information, about the mice in the Resource. Resource personnel also provide a core of geneticists who have many years of experience and extensive knowledge and expertise in a variety of areas related to gene mapping, mouse genetics, and mouse husbandry and biology. The MMR occupies 7,345 ft2 of vivarium and procedure space in Building 32 and the Functional Genomics Building. Dr. Muriel Davisson, Senior Staff Scientist, Director of Genetic Resources, is the Project Leader responsible for administration and coordination of Mouse Models Resource programs with each other and with other Resources and Scientific Services at TJL.

小鼠模型资源（MMR）为TJL癌症中心的研究人员提供了访问 从TJL的遗传资源中获得的2，900种公开可用的菌株中， 仓库。MMR还提供了有关这些菌株的信息，以及科学家在这方面的专业知识。 遗传资源计划。活资源，连同可从 冷冻保存资源包括遗传资源库，是最大的单一收藏 基因定义的小鼠品系。鼠标模型资源提供TJL 癌症中心的成员与少量的小鼠从仓库免费。癌症中心 成员可以从突变株中获得育种对和少量突变体和对照，或 来自品系组的个体小鼠。癌症中心的成员通过进一步增加菌株的价值 这些科学信息被添加到应变信息数据库中， 出版物或通过电子传输直接进入小鼠表型数据库用于菌株组。的 资源包含携带自发、诱导和基因工程突变的小鼠品系; 染色体畸变的小鼠;以及特殊的近交系和品系组，包括野生来源的 近交系、同源系、重组近交系（R1）和同源系。为防止损失和 对极低需求菌株的经济管理，所有菌株均作为胚胎或配子冷冻保存 通过生殖科学计划，大多数品系的DNA都可以通过小鼠获得。 基因组科学中的DNA资源。遗传资源技术信息科学家收集，策划， 并保持这些菌株的操作和科学信息。鼠标模型资源 人员提供遗传专业知识和建议，以及殖民地维护建议，包括特别的 畜牧业需要和生物信息，关于老鼠的资源。资源人员还 提供具有多年经验和广泛知识和专业知识的遗传学家核心 在与基因图谱、小鼠遗传学、小鼠饲养和生物学相关的各种领域。的 MMR占据了32号楼7，345平方英尺的动物园和手术空间，功能基因组学 建设Muriel Davisson博士，高级科学家，遗传资源主任，是项目负责人 负责管理和协调小鼠模型资源计划， 与TJL的其他资源和科学服务。