MMRRC Annual Meeting

MMRRC年会

• 批准号: 8061271
• 负责人: LEAH RAE B DONAHUE
• 金额: $ 1.8万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-03 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061271
• 关键词: Address; Affect; Animal Model; Archives; Atlases; Beta Cell; Biological Preservation; Biomedical Research; California; Cellular biology; Collection; Communication; Communities; Country; Defect; Development; Disease; ES Cell Line; Effectiveness; Ensure; Equipment and supply inventories; Ethylnitrosourea; Funding; Gene Expression; Genes; Genetically Engineered Mouse; Genomics; Goals; Growth; Human; Human Resources; Individual; Informatics; Institution; Life; Link; Maine; Metric; Missouri; Modeling; Monitor; Mouse Strains; Mus; Mutagenesis; Mutant Strains Mice; Mutation; National Center for Research Resources; Nature; Nervous system structure; Neurosciences; North Carolina; Organizational Policy; Orthologous Gene; Pathology; Performance; Persons; Pharmaceutical Preparations; Pigmentation physiologic function; Policies; Prevention strategy; Principal Investigator; Request for Proposals; Research; Research Personnel; Research Support; Resource Sharing; Resources; Safety; Scientist; Services; Stream; Teleconferences; Testing; The Jackson Laboratory; Therapeutic; Time; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; biological systems; comparative; cost; cost effective; genome sequencing; human disease; meetings; member; model development; mouse model; mutant; mutant mouse model; operation; organizational structure; pre-clinical research; programs; repository; stem cell technology; success; symposium

DESCRIPTION (provided by applicant): The Mutant Mouse Regional Resource Center (MMRRC) is a major NIH-supported national mutant mouse archive and distribution consortium that provides genetically altered mice, cryopreserved materials, embryonic stem (ES) cell lines, technical support, and value-added services to the biomedical research community. The MMRRC Program is supported by the NIH National Center for Research Resources (NCRR) and is organized through U42 cooperative agreements that administratively and operationally link the NCRR with 4 repositories located strategically in the Western (University of California-Davis), Central (University of Missouri), and Eastern (University of North Carolina-Chapel Hill and The Jackson Laboratory) USA, and an Informatics, Coordination and Service Center (ICSC; The Jackson Laboratory). This organizational structure ensures the protection, preservation, and availability of mutant mouse strains for research by academic and, as of 2010, for-profit investigators and enables NIH-funded researchers to meet the NIH resource-sharing requirement in a convenient and cost-effective manner. In its 11th year of operation, the MMRRC (www.mmrrc.org), as of 1 April 2010, has grown to an inventory of 2,234 mutant and genetically engineered mouse models maintained either as live colonies or cryopreserved germplasm, and 27,627 ES cell lines. In 2010, the MMRRC program was expanded by adding The Jackson Laboratory, an internationally recognized mouse resource center, as the fourth MMRRC repository. During its first 10 years, the MMRRC's original 3 repositories together filled over 6,629 orders from 2,170 investigators at over 1,430 institutions worldwide. Over 325 investigators and 10 major NIH-funded resource model development programs have preserved their strains and ES cell lines using the MMRRC. A multi-institutional, regionally distributed program of this size requires frequent communication. Monthly teleconferences are used to coordinate operations; however, annual meetings are critical to provide sufficient time and face-to-face interactions to discuss long-term strategies to ensure that the MMRRC Program continues to serve the rapidly evolving needs of the scientific community. These annual meetings also are invaluable to address numerous operational, organizational, and policy issues and develop strategies to continue to enhance the effectiveness of the MMRRC program. Therefore, this proposal requests $18,030 to support the 9th Annual MMRRC Meeting in May 2011 at The Jackson Laboratory in Bar Harbor, Maine. This meeting will bring together the Principal Investigators and other key personnel from each of the 4 repositories and the ICSC, NCRR and other NIH Program staff. The goals of this meeting will be to 1) critically and objectively review and assess MMRRC operational and performance metrics, 2) discuss research goals and accomplishments of individual centers, and 3) develop strategies for meeting ongoing and evolving needs of the scientific research community using mouse resources. The continued growth and success of the MMRRC Program has shown the value of these annual meetings. ) PUBLIC HEALTH RELEVANCE (provided by applicant): The Mutant Mouse Regional Resource Center (MMRRC) is a major NIH-supported national mutant mouse archive and distribution consortium that provides invaluable resources to the biomedical research community: genetically altered mice, cryopreserved materials, embryonic stem (ES) cell lines, technical support, and value- added services. Mouse models for human disorders and for basic biomedical research are critical to understand biological systems affected by human diseases. With a sequenced genome and increasingly sophisticated stem cell technologies to manipulate it, the mouse remains the most powerful model organism for biomedical research. Genetically engineered mouse models with mutations in orthologs of human genes are critical for translational and pre clinical research. They enable scientists to understand the causes, pathologies and progression of human diseases so that prevention strategies or therapeutics for these diseases can be developed. In addition, therapies or drugs can be tested on mouse models prior to human trials to assess efficacy and safety. Communication among MMRRC components is critical for its continued success in meeting evolving needs of biomedical research community.

描述（由申请人提供）：突变小鼠区域资源中心（MMRRC）是美国国立卫生研究院支持的一个主要的国家突变小鼠档案和分发联盟，为生物医学研究界提供转基因小鼠、冷冻保存材料、胚胎干（ES）细胞系、技术支持和增值服务。MMRRC计划由美国国立卫生研究院国家研究资源中心（NCRR）支持，并通过U42合作协议组织，该协议将NCRR与位于美国西部（加州大学戴维斯分校）、中部（密苏里大学）和东部（北卡罗来纳大学教堂山分校和杰克逊实验室）的4个资源库以及信息学、协调和服务中心（ICSC；杰克逊实验室）在行政和操作上联系起来。这种组织结构确保了突变小鼠株的保护、保存和可用性，以供学术研究人员和营利性研究人员进行研究，并使NIH资助的研究人员能够以方便和经济有效的方式满足NIH资源共享的要求。截至2010年4月1日，MMRRC （www.mmrrc.org）已经运行了11年，拥有2234个突变和基因工程小鼠模型，有的是活菌种，有的是冷冻种质，还有27627个胚胎干细胞系。2010年，MMRRC项目得到扩展，国际公认的老鼠资源中心杰克逊实验室成为MMRRC的第四个储存库。在最初的10年里，MMRRC最初的3个知识库总共满足了来自全球1430多个机构的2170名研究人员的6629份订单。超过325名研究人员和10个主要的nih资助的资源模型开发项目使用MMRRC保存了他们的菌株和胚胎干细胞系。这种规模的多机构、区域分布的项目需要频繁的沟通。每月召开一次电话会议来协调行动；然而，年会对于提供足够的时间和面对面的交流来讨论长期战略是至关重要的，以确保MMRRC计划继续服务于科学界快速发展的需求。这些年度会议对于解决许多业务、组织和政策问题以及制定战略以继续提高MMRRC计划的有效性也非常宝贵。因此，本提案请求18030美元，用于支持2011年5月在缅因州巴尔港杰克逊实验室举行的第九届MMRRC年度会议。本次会议将汇集来自4个存储库的主要研究人员和其他关键人员以及ICSC， NCRR和其他NIH项目工作人员。本次会议的目标将是1)批判性和客观地审查和评估MMRRC的运营和绩效指标，2)讨论单个中心的研究目标和成就，以及3)制定策略，以满足科学研究界使用小鼠资源的持续和不断变化的需求。MMRRC项目的持续增长和成功表明了这些年度会议的价值。