Neural Substrates of Electroacupuncture in Cardiovascular Control
电针控制心血管的神经基质
基本信息
- 批准号:8456056
- 负责人:
- 金额:$ 36.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-07-01 至 2017-06-30
- 项目状态:已结题
- 来源:
- 关键词:AbbreviationsAcupuncture procedureAcuteAdverse effectsAmericanAnimalsAreaAutomobile DrivingBiologic CharacteristicBlood PressureBrainCardiovascular systemCell NucleusCholecystokinin A ReceptorCholecystokinin ReceptorClinicalConsciousDataDiseaseElectroacupunctureEndorphinsEnkephalinsFigs - dietaryGenesGlutamatesGoalsGrantHourHypertensionHypotensionHypothalamic structureIncidenceInvestigationKnowledgeMedicalMessenger RNAMethodsMidbrain structureModalityModelingMolecularMorbidity - disease rateMyocardial IschemiaNational Center for Complementary and Alternative MedicineNational Heart, Lung, and Blood InstituteNeuronsNeurotransmittersOpioidOrangesPathway interactionsPatientsPhysiciansPhysiologicalPlayPopulationPro-OpiomelanocortinProcessProductionRattusReflex actionRegulationResearchRoleSpinal CordStandardizationStructure of nucleus infundibularis hypothalamiTetragastrinTextThoracic spinal cord structureTreatment ProtocolsVisceralWhole Organismagedhemodynamicshypertension treatmentimprovedinsightmRNA Expressionmidbrain central gray substancemortalityneuromechanismneurophysiologyneuroregulationparaventricular nucleuspreproenkephalinraphe nucleirelating to nervous systemresponse
项目摘要
DESCRIPTION (provided by applicant): We have investigated the mechanisms by which acupuncture, particularly electroacupuncture (EA) regulates blood pressure (BP). EA has the capability to lower elevated BP and to alleviate demand-induced myocardial ischemia. Its actions are slow in onset but its duration of action is prolonged. Approximately 70% of experimental subjects with acute reflex-induced elevations in BP respond to EA. The most recent grant has focused on a long-loop pathway extending from the hypothalamic arcuate nucleus to the midbrain ventrolateral periaqueductal gray (vlPAG) to the medullary midline nucleus raphe' pallidus (NRP) and then the rostral ventrolateral medulla (rVLM) where the activity of premotor sympathetic neurons is inhibited by EA. We specifically identified a reinforcing reciprocating network between the arcuate and the vlPAG that serves to prolong the action of EA. We also defined an important role for the NRP as a nucleus that processes glutamatergic input from the vlPAG and through a 5-HT1A rVLM mechanism modulates sympathetic outflow. The central hypothesis of this competitive renewal is that a standardized course of acupuncture treatment and established methods convert nonresponders to responders to increase EA's efficacy in reducing elevated blood pressure (BP), particularly through its inhibitory action in the hypothalamic paraventricular nucleus (PVN). The present grant will focus on four new areas: 1) the role of the PVN modulated during EA by opioid (enkephalin and endorphinergic) inputs from the arcuate and through projections to the rVLM and IML inhibits reflex-evoked sympathetic activation, 2) the mechanism through which repetitive EA in conscious cold-induced hypertensive (CI-HTN) rats lowers BP, 3) transcriptional mechanisms regulating enkephalin and endorphin production in the rVLM and arcuate during repetitive stimulation in EA's action to lower BP in CI-HTN rats and 4) cholecystokinin neuromodulation of opioid activity in the PVN of animals unresponsive to the actions of EA. Anatomical, physiological, electrophysiological, pharmacological and molecular approaches will be used in the proposed studies that are highly relevant to patients that have the potential to benefit from clinical acupuncture.
描述(由申请人提供):我们研究了针灸,特别是电针(EA)调节血压(BP)的机制。 EA 能够降低升高的血压并缓解需求引起的心肌缺血。其作用起效缓慢,但作用持续时间较长。大约 70% 的急性反射诱发血压升高的实验对象对 EA 有反应。最近的资助重点是一条长环通路,从下丘脑弓状核延伸到中脑腹外侧导水管周围灰质(vlPAG),再到髓质中线中缝苍白核(NRP),然后延伸到头侧延髓腹外侧(rVLM),其中运动前交感神经元的活性被电针抑制。我们特别确定了弓形和 vlPAG 之间的加强往复网络,用于延长 EA 的作用。我们还定义了 NRP 的重要作用,即处理来自 vlPAG 的谷氨酸输入并通过 5-HT1A rVLM 机制调节交感神经流出的细胞核。这种竞争性更新的核心假设是,针灸治疗的标准化疗程和既定方法可以将无反应者转变为有反应者,以提高 EA 在降低高血压 (BP) 方面的功效,特别是通过其对下丘脑室旁核 (PVN) 的抑制作用。目前的资助将集中在四个新领域:1)在 EA 过程中,PVN 通过来自弓形的阿片类药物(脑啡肽和内啡能)输入以及通过投射到 rVLM 和 IML 抑制反射诱发的交感神经激活来调节 PVN 的作用,2)意识冷诱导高血压(CI-HTN)大鼠中重复 EA 降低血压的机制,3)转录 CI-HTN 大鼠中 EA 降低血压的重复刺激过程中调节 rVLM 和弓形中脑啡肽和内啡肽产生的机制,以及 4) 对 EA 作用无反应的动物 PVN 中阿片类药物活性的胆囊收缩素神经调节。解剖学、生理学、电生理学、药理学和分子方法将用于拟议的研究,这些研究与有可能从临床针灸中受益的患者高度相关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John C Longhurst其他文献
John C Longhurst的其他文献
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{{ truncateString('John C Longhurst', 18)}}的其他基金
NEURAL MECHANISM OF THE EFFECT OF ACUPUNCTURE ON MYOCARDIAL ISCHEMIA
针刺治疗心肌缺血的神经机制
- 批准号:
8166890 - 财政年份:2009
- 资助金额:
$ 36.65万 - 项目类别:
NEURAL MECHANISM OF THE EFFECT OF ACUPUNCTURE ON MYOCARDIAL ISCHEMIA
针刺治疗心肌缺血的神经机制
- 批准号:
7951021 - 财政年份:2008
- 资助金额:
$ 36.65万 - 项目类别:
NEURAL MECHANISM OF THE EFFECT OF ACUPUNCTURE ON MYOCARDIAL ISCHEMIA
针刺治疗心肌缺血的神经机制
- 批准号:
7724977 - 财政年份:2007
- 资助金额:
$ 36.65万 - 项目类别:
NEURAL MECHANISM OF THE EFFECT OF ACUPUNCTURE ON MYOCARDIAL ISCHEMIA
针刺治疗心肌缺血的神经机制
- 批准号:
7606601 - 财政年份:2006
- 资助金额:
$ 36.65万 - 项目类别:
NEURAL MECHANISM OF THE EFFECT OF ACUPUNCTURE ON MYOCARDIAL ISCHEMIA
针刺治疗心肌缺血的神经机制
- 批准号:
7374241 - 财政年份:2006
- 资助金额:
$ 36.65万 - 项目类别:
Neural Substrates of EA in Cardiovascular Control
EA 在心血管控制中的神经基质
- 批准号:
6747727 - 财政年份:2003
- 资助金额:
$ 36.65万 - 项目类别:
Neural Substrates of Electroacupuncture in Cardiovascular Control
电针控制心血管的神经基质
- 批准号:
8874256 - 财政年份:2003
- 资助金额:
$ 36.65万 - 项目类别:
Neural Substrates of EA in Cardiovascular Control
EA 在心血管控制中的神经基质
- 批准号:
7878742 - 财政年份:2003
- 资助金额:
$ 36.65万 - 项目类别:
Neural Substrates of EA in Cardiovascular Control
EA 在心血管控制中的神经基质
- 批准号:
7078637 - 财政年份:2003
- 资助金额:
$ 36.65万 - 项目类别:
Neural Substrates of EA in Cardiovascular Control
EA 在心血管控制中的神经基质
- 批准号:
7233822 - 财政年份:2003
- 资助金额:
$ 36.65万 - 项目类别: