Novel Pelvic Floor Pain Measures to Enhance Female Pelvic Pain Evaluation

新型盆底疼痛措施可增强女性盆腔疼痛评估

基本信息

批准号：
8314121
负责人：
Frank Fu-sheng Tu
金额：
$ 10.8万
依托单位：
NORTHSHORE UNIVERSITY HEALTHSYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8314121
关键词：
Abdomen Accounting Address Affect Age Analgesics Anxiety Area Bladder Botulinum Toxins Cognitive Therapy Combined Modality Therapy Constipation Cross-Sectional Studies Data Detection Development Diagnosis Diagnostic Diagnostic tests Disease Disease Progression Disease model Distress Epidemiology Esthesia Etiology Evaluation Exhibits Failure Female Functional disorder Gastroenterology Genitourinary system Goals Gynecologic Gynecologist Gynecology Human Hypersensitivity Inflammation Inflammatory Injection of therapeutic agent Interstitial Cystitis Intervention Irritable Bowel Syndrome Measures Mental Depression Mentorship Methods Multi-Institutional Clinical Trial Muscle Myalgia Natural History Neurologic Neurology Observational Study Outcome Study Pain Pain Assessment Tool Pain Disorder Pain Measurement Pain Threshold Pain intensity Pain-Free Palpation Pathway interactions Patients Pelvic Floor Muscle Pelvic Pain Pelvic floor structure Pelvis Peripheral Physical therapy Physiological Physiology Psychological Factors Psychology Qualifying Recording of previous events Relative (related person)Reporting Research Research Personnel Role Screening procedure Severities Structure Symptoms Syndrome Testing Time Tissues Training Universities Urology Vagina Validation Visceral Visceral pain Vulvodynia Wisconsin Woman Work base biopsychosocial burden of illness case control central sensitization chronic pelvic pain clinically relevant design disability dorsal horn effective therapy experience improved innovation insight instrument levator ani muscle male men novel obturator muscle painful bladder syndrome painful neuropathy pressure programs prospective psychologic reproductive response tool urologic

项目摘要

DESCRIPTION (provided by applicant): A major shortcoming in the present diagnostic framework for painful bladder syndrome (PBS) and related pelvic pain disorders is the failure to incorporate objective measures of pain sensitivity. As a gynecologist, the applicant's long-term research goal is to define modifiable disease mechanisms in urogenital pain syndromes. Through the present application, he seeks training in the physiological assessment of pain in order to mechanistically subtype pelvic pain patients. At present, failure to systematically diagnose heterogeneous etiologies in pelvic pain hinders the rational use of specific interventions. A two part-program is proposed. First, under a structured program of mentorship (drawn from gynecology, urology, gastroenterology, psychology, physiology, and neurology) he will study relevant pain physiology and pertinent correlates of the human pain experience. The candidate will engage in both formal didactic and experiential training in design of multi-site clinical trials, assessment of pain physiology in diseased states, and characterization of psychological determinants of pain experience. Simultaneously, he will gain practical experience while conducting a prospective observational study of one important but understudied aspect of PBS and related pelvic pain syndromes: pelvic floor pain dysfunction. The central hypothesis is that women suffering from PBS have increased pelvic floor pain sensitivity (i.e., worse pain when the muscles are examined by a clinician) compared to healthy controls. This hypothesis will be tested using three specific aims: 1) Determine whether pelvic floor (somatic) pain sensitivity is enhanced in PBS; 2) Determine correlates of enhanced bladder (visceral) pain sensitivity; and 3) To correlate urogenital distress among PBS patients and pain-free controls with pelvic muscle pain sensitivity, visceral pain sensitivity, and psychological factors. The approach is innovative, by employing accepted pain assessment tools to an important, understudied area: the pelvic floor musculature. The research proposed in this application is significant for improving diagnosis of PBS and other pelvic pain syndromes in both women and men. Objective, valid measures of pelvic floor pain dysfunction will allow rational application of mechanism-specific treatments, such as physical therapy, neuropathic pain medications, cognitive-behavioral therapy, or botulinum toxin injections. Public Narrative: The outcomes of this study will likely enhance our approach to the assessment of pain symptomatology not only in PBS, but in all pelvic pain syndromes associated with pelvic floor sensitivity or irritative voiding symptoms.

描述（由申请人提供）：目前的疼痛膀胱综合征（PBS）和相关骨盆疼痛障碍的诊断框架中的一个主要缺点是未能纳入疼痛敏感性的客观度量。作为妇科医生，申请人的长期研究目标是定义泌尿生殖器疼痛综合征的可修改疾病机制。通过本应用，他寻求培训疼痛的生理评估，以便对骨盆疼痛患者进行机械性疼痛。目前，未能系统地诊断骨盆疼痛中的异质病因会阻碍特定干预措施的合理使用。提出了两个部分编程。首先，根据指导的结构化计划（源自妇科，泌尿外科，胃肠病学，心理学，生理学和神经病学），他将研究相关的疼痛生理学和人类疼痛经验的相关性。候选人将在多站点临床试验的设计，患病状态的疼痛生理学评估以及对疼痛经验的心理决定因素的表征方面进行正式的教学和体验培训。同时，他将对PBS和相关骨盆疼痛综合征的一个重要但研究的前瞻性观察性研究进行实践经验：骨盆底疼痛功能障碍。与健康对照组相比，患有PBS的女性的中心假设是，患有PBS的女性增加了骨盆底疼痛敏感性（即，当临床医生检查肌肉时疼痛较差）。该假设将使用三个特定目的进行检验：1）确定PBS中骨盆底（体细胞）疼痛敏感性是否增强； 2）确定增强的膀胱（内脏）疼痛敏感性的相关性； 3）将PBS患者的泌尿生殖器和无痛对照与骨盆肌肉疼痛敏感性，内脏疼痛敏感性和心理因素相关联。通过在重要的，研究的领域使用公认的疼痛评估工具：骨盆底肌肉组织，这种方法具有创新性。该应用中提出的研究对于改善男性和男性的PBS和其他骨盆疼痛综合症的诊断至关重要。骨盆底疼痛功能障碍的目的，有效的措施将允许合理地应用机制特异性治疗，例如物理疗法，神经性止痛药，认知行为疗法或肉毒杆菌毒素注射。公众叙述：这项研究的结果可能会增强我们评估疼痛症状的方法，不仅在PBS中，而且在所有与骨盆底敏感性或刺激性空隙症状相关的骨盆疼痛综合征中。