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Novel Pelvic Floor Pain Measures to Enhance Female Pelvic Pain Evaluation

新型盆底疼痛措施可增强女性盆腔疼痛评估

基本信息

批准号：
8314121
负责人：
Frank Fu-sheng Tu
金额：
$ 10.8万
依托单位：
NORTHSHORE UNIVERSITY HEALTHSYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8314121
关键词：
Abdomen Accounting Address Affect Age Analgesics Anxiety Area Bladder Botulinum Toxins Cognitive Therapy Combined Modality Therapy Constipation Cross-Sectional Studies Data Detection Development Diagnosis Diagnostic Diagnostic tests Disease Disease Progression Disease model Distress Epidemiology Esthesia Etiology Evaluation Exhibits Failure Female Functional disorder Gastroenterology Genitourinary system Goals Gynecologic Gynecologist Gynecology Human Hypersensitivity Inflammation Inflammatory Injection of therapeutic agent Interstitial Cystitis Intervention Irritable Bowel Syndrome Measures Mental Depression Mentorship Methods Multi-Institutional Clinical Trial Muscle Myalgia Natural History Neurologic Neurology Observational Study Outcome Study Pain Pain Assessment Tool Pain Disorder Pain Measurement Pain Threshold Pain intensity Pain-Free Palpation Pathway interactions Patients Pelvic Floor Muscle Pelvic Pain Pelvic floor structure Pelvis Peripheral Physical therapy Physiological Physiology Psychological Factors Psychology Qualifying Recording of previous events Relative (related person)Reporting Research Research Personnel Role Screening procedure Severities Structure Symptoms Syndrome Testing Time Tissues Training Universities Urology Vagina Validation Visceral Visceral pain Vulvodynia Wisconsin Woman Work base biopsychosocial burden of illness case control central sensitization chronic pelvic pain clinically relevant design disability dorsal horn effective therapy experience improved innovation insight instrument levator ani muscle male men novel obturator muscle painful bladder syndrome painful neuropathy pressure programs prospective psychologic reproductive response tool urologic

项目摘要

DESCRIPTION (provided by applicant): A major shortcoming in the present diagnostic framework for painful bladder syndrome (PBS) and related pelvic pain disorders is the failure to incorporate objective measures of pain sensitivity. As a gynecologist, the applicant's long-term research goal is to define modifiable disease mechanisms in urogenital pain syndromes. Through the present application, he seeks training in the physiological assessment of pain in order to mechanistically subtype pelvic pain patients. At present, failure to systematically diagnose heterogeneous etiologies in pelvic pain hinders the rational use of specific interventions. A two part-program is proposed. First, under a structured program of mentorship (drawn from gynecology, urology, gastroenterology, psychology, physiology, and neurology) he will study relevant pain physiology and pertinent correlates of the human pain experience. The candidate will engage in both formal didactic and experiential training in design of multi-site clinical trials, assessment of pain physiology in diseased states, and characterization of psychological determinants of pain experience. Simultaneously, he will gain practical experience while conducting a prospective observational study of one important but understudied aspect of PBS and related pelvic pain syndromes: pelvic floor pain dysfunction. The central hypothesis is that women suffering from PBS have increased pelvic floor pain sensitivity (i.e., worse pain when the muscles are examined by a clinician) compared to healthy controls. This hypothesis will be tested using three specific aims: 1) Determine whether pelvic floor (somatic) pain sensitivity is enhanced in PBS; 2) Determine correlates of enhanced bladder (visceral) pain sensitivity; and 3) To correlate urogenital distress among PBS patients and pain-free controls with pelvic muscle pain sensitivity, visceral pain sensitivity, and psychological factors. The approach is innovative, by employing accepted pain assessment tools to an important, understudied area: the pelvic floor musculature. The research proposed in this application is significant for improving diagnosis of PBS and other pelvic pain syndromes in both women and men. Objective, valid measures of pelvic floor pain dysfunction will allow rational application of mechanism-specific treatments, such as physical therapy, neuropathic pain medications, cognitive-behavioral therapy, or botulinum toxin injections. Public Narrative: The outcomes of this study will likely enhance our approach to the assessment of pain symptomatology not only in PBS, but in all pelvic pain syndromes associated with pelvic floor sensitivity or irritative voiding symptoms.

描述(申请人提供)：目前对痛性膀胱综合征(PBS)和相关的盆腔疼痛疾病的诊断框架的一个主要缺陷是未能纳入疼痛敏感性的客观测量。作为一名妇科医生，申请者的长期研究目标是确定泌尿生殖系统疼痛综合征的可改变的疾病机制。通过目前的应用，他寻求在疼痛的生理评估方面的培训，以便对骨盆疼痛患者进行机械分型。目前，未能系统地诊断盆腔疼痛的不同病因，阻碍了特定干预措施的合理使用。提出了一种分两部分的方案。首先，在一个结构化的指导计划下(来自妇科、泌尿外科、胃肠病学、心理学、生理学和神经学)，他将研究相关的疼痛生理学和人类疼痛体验的相关关联。应聘者将在设计多点临床试验、评估疾病状态下的疼痛生理学以及表征疼痛体验的心理决定因素方面进行正式的授课和经验培训。同时，他将获得实践经验，同时对PBS和相关骨盆疼痛综合征的一个重要但研究不足的方面进行前瞻性观察研究：盆底疼痛功能障碍。中心假设是，与健康对照组相比，患有PBS的女性盆底疼痛敏感度增加(即当临床医生检查肌肉时，疼痛更严重)。这一假设将通过三个具体目标进行检验：1)确定PBS患者的盆底(躯体)疼痛敏感性是否增强；2)确定膀胱(内脏)疼痛敏感性增强的相关性；以及3)将PBS患者和无痛对照组中的泌尿生殖系统窘迫与盆腔肌肉疼痛敏感性、内脏疼痛敏感性和心理因素联系起来。这种方法是创新的，将公认的疼痛评估工具应用到一个重要的、研究不足的领域：盆底肌肉系统。本申请中提出的研究对于提高PBS和其他盆腔疼痛综合征的诊断水平具有重要意义。目的：盆底疼痛功能障碍的有效措施将允许合理应用特定机制的治疗，如物理治疗、神经病理性疼痛药物、认知行为治疗或肉毒杆菌毒素注射。公开叙述：这项研究的结果可能会加强我们对疼痛症状的评估方法，不仅在PBS，而且在所有与盆底敏感或刺激性排尿症状相关的盆腔疼痛综合征中。