Training of the Pediatric Emergency Physician-Scientist

描述（由申请人提供）：这是第一次更新提交的儿科急诊医学NICHD机构培训补助金申请，旨在为华盛顿大学圣路易斯医学院（WUMS）的儿科提供必要的资金，以招募和教育合格的医生科学家。我们的长期目标是利用这笔资金促进年轻医生科学家的职业发展，这些科学家将成为生物医学研究工作的未来领导者，致力于改善患有紧急医疗状况的儿童的健康状况。这项建议的具体目标是在实习期结束时确定潜在的受训人员，并为他们提供两年的实验室研究经验，由合格的导师指导，或提供严格的以病人为导向的研究经验，免受临床和教学责任的影响。研究的重点将是儿科急诊医学中的儿童健康问题，包括高度优先的以患者为导向的研究，重点是灾难性疾病，紧急护理和长期残疾之间的关系。我们也将强调感染和免疫的分子机制，以及创伤性或非创伤性休克状态引起的多器官功能障碍综合征（MODS）。我们将通过创建两个轨道来实现这一目标：（1）以患者为导向的研究，以及（2）感染，免疫和MODS的分子机制。细胞、分子和发育生物学的最新进展将用于理解感染、免疫和MODS的发病机制和治疗。同样严格的以病人为导向的研究方法将被应用于改善高优先级的紧急医疗和外科疾病的结果，利用WUMS及其儿科的全部设施。我们已经建立了一个结构，在这个结构中，聪明、有动力的年轻儿科医生将在一个受保护的环境中蓬勃发展，并将成为儿科这个不断发展的子专业的领导者。我们计划每年招收一名博士后研究员，为期5年。每名研究员的拟议培训期限为2年。该计划利用了25名已建立的调查人员，他们将担任导师。长期目标将实现，因为它的学员有助于在未来二十年或更长时间内发展和领导儿科急诊医生科学家。 公共卫生相关性：该项目旨在资助美国儿科急诊医学仅有的两个培训赠款之一。该计划的目标是培养一支儿科急诊医生-科学家队伍，他们将在基础和转化研究方面有所发现，从而改善患有紧急医疗和外科疾病的儿童的健康状况。正如医学研究所2006年的报告所指出的那样，“增加儿科急诊护理研究的回报，虽然难以量化，但将包括挽救生命，降低发病率，以及更有效和更有效的急诊护理系统。"

DESCRIPTION (provided by applicant): This is the first renewal submission of an application for an NICHD Institutional Training Grant in Pediatric Emergency Medicine intended to provide the Department of Pediatrics at Washington University in St. Louis School of Medicine (WUMS) with the funds necessary to recruit and educate qualified physician-scientists. Our long-term objective is to use this funding to promote the career development of young physician scientists who will become future leaders in biomedical research efforts dedicated to improving health outcomes for children with emergency medical conditions. The specific aims of this proposal are to identify potential trainees at the completion of their residency and to provide them with a two-year research experience in the laboratory of a qualified mentor or with a comparably rigorous mentored patient-oriented research experience, protected from clinical and teaching responsibilities. The focus of the research will be on child health issues in pediatric emergency medicine, including high-priority patient-oriented research with emphasis on the relationship between catastrophic illness, emergency care and long-term disabilities. We will also emphasize molecular mechanisms of infection and immunity, and multiple organ dysfunction syndrome (MODS) arising from traumatic or non-traumatic shock states. We will achieve this goal by creating two tracks: (1) patient-oriented research, and (2) the molecular mechanisms of infection, immunity, and MODS. Recent advances in cell, molecular, and developmental biology will be applied to understanding the pathogenesis and treatment of infection, immunity and MODS. Similarly rigorous patient-oriented research methods will be applied to improve outcomes of high-priority emergency medical and surgical diseases, using the full facilities of the WUMS and its Department of Pediatrics. We have in place a structure in which bright, motivated young pediatricians will flourish in a protected environment and will emerge as leaders in this evolving subspecialty of pediatrics. We plan to enroll one new post-doctoral fellow per year for a 5-year period. The proposed duration of training for each fellow is 2 years. The program takes advantage of 25 established investigators who will serve as mentors. The long-term goals will be realized as its trainees contribute to the development of and leadership as pediatric emergency physician-scientists during the next two or more decades. PUBLIC HEALTH RELEVANCE: This project is designed to fund one of only 2 training grants in Pediatric Emergency Medicine in the United States. The goal of this program is to train a cadre of Pediatric Emergency Physician- Scientists who will make discoveries in both basic and translational research that will lead to the improvement of health outcomes in children with emergency medical and surgical conditions. As the 2006 report of the Institute of Medicine stated "The payoff from increased pediatric emergency care research, while difficult to quantify, will include lives saved, decreased morbidity, and a more efficient and effective emergency care system."