Training of the Pediatric Emergency Physician-Scientist

描述（由申请人提供）：这是NICHD儿科急诊医学机构培训补助金申请的第一次更新提交，旨在为华盛顿大学圣路易斯医学院（WUMS）儿科部门提供招募和教育合格的内科科学家所需的资金。我们的长期目标是利用这笔资金促进年轻医师科学家的职业发展，他们将成为致力于改善紧急医疗条件下儿童健康结果的生物医学研究工作的未来领导者。该提案的具体目的是在实习结束时确定潜在的培训生，并为他们提供在合格导师的实验室中进行两年研究的经验，或提供相对严格的以患者为导向的指导研究经验，免受临床和教学责任的影响。研究的重点将放在儿科急诊医学中的儿童健康问题上，包括高度优先的以患者为导向的研究，重点是灾难性疾病、急诊护理和长期残疾之间的关系。我们还将强调感染和免疫的分子机制，以及创伤性或非创伤性休克状态引起的多器官功能障碍综合征（MODS）。我们将通过创建两个轨道来实现这一目标：(1)以患者为导向的研究；(2)感染、免疫和MODS的分子机制。细胞、分子和发育生物学的最新进展将应用于了解感染、免疫和MODS的发病机制和治疗。将采用同样严格的以病人为导向的研究方法，利用妇女综合医院及其儿科的全部设施，改善高度优先的紧急医疗和外科疾病的结果。我们已经建立了一种结构，在这种结构中，聪明、积极的年轻儿科医生将在受保护的环境中茁壮成长，并将成为儿科这一不断发展的亚专业的领导者。我们计划每年招收1名博士后，为期5年。建议每位研究员的培训期限为2年。该项目将利用25名知名调查人员作为导师。在未来二十年或更长的时间里，其学员将为儿科急诊医师和科学家的发展和领导做出贡献，从而实现长期目标。

DESCRIPTION (provided by applicant): This is the first renewal submission of an application for an NICHD Institutional Training Grant in Pediatric Emergency Medicine intended to provide the Department of Pediatrics at Washington University in St. Louis School of Medicine (WUMS) with the funds necessary to recruit and educate qualified physician-scientists. Our long-term objective is to use this funding to promote the career development of young physician scientists who will become future leaders in biomedical research efforts dedicated to improving health outcomes for children with emergency medical conditions. The specific aims of this proposal are to identify potential trainees at the completion of their residency and to provide them with a two-year research experience in the laboratory of a qualified mentor or with a comparably rigorous mentored patient-oriented research experience, protected from clinical and teaching responsibilities. The focus of the research will be on child health issues in pediatric emergency medicine, including high-priority patient-oriented research with emphasis on the relationship between catastrophic illness, emergency care and long-term disabilities. We will also emphasize molecular mechanisms of infection and immunity, and multiple organ dysfunction syndrome (MODS) arising from traumatic or non-traumatic shock states. We will achieve this goal by creating two tracks: (1) patient-oriented research, and (2) the molecular mechanisms of infection, immunity, and MODS. Recent advances in cell, molecular, and developmental biology will be applied to understanding the pathogenesis and treatment of infection, immunity and MODS. Similarly rigorous patient-oriented research methods will be applied to improve outcomes of high-priority emergency medical and surgical diseases, using the full facilities of the WUMS and its Department of Pediatrics. We have in place a structure in which bright, motivated young pediatricians will flourish in a protected environment and will emerge as leaders in this evolving subspecialty of pediatrics. We plan to enroll one new post-doctoral fellow per year for a 5-year period. The proposed duration of training for each fellow is 2 years. The program takes advantage of 25 established investigators who will serve as mentors. The long-term goals will be realized as its trainees contribute to the development of and leadership as pediatric emergency physician-scientists during the next two or more decades.