Adiposity, Disease Risk Factors, and Lifetime Health

肥胖、疾病危险因素和终生健康

• 批准号: 8298577
• 负责人: STEFAN A. CZERWINSKI
• 金额: $ 136.25万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-07-06 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8298577
• 关键词: Abdomen; Adipose tissue; Adult; Age; Biological; Biological Assay; Body Composition; Body mass index; Cardiovascular Diseases; Central obesity; Childhood; Chronic Disease; Cross-Sectional Studies; Data; Data Analyses; Data Collection; Databases; Deposition; Development; Diet; Disease; Dyslipidemias; Early Diagnosis; Etiology; Fatty acid glycerol esters; Female; Future; General Population; Growth; Health; Hormonal; Image; Individual; Inflammatory; Insulin Resistance; Interleukin-6; Knowledge; Lead; Leptin; Life; Life Style; Link; Liver; Liver diseases; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Metabolic; Metabolic Diseases; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Participant; Pathway interactions; Pattern; Physical activity; Physiological; Play; Population; Prevention Guidelines; Process; Public Health; Recording of previous events; Research; Risk; Risk Factors; Role; Slice; Smoking; Statistical Models; Symptoms; Testing; Time; Tumor Necrosis Factor-alpha; United States; Visceral; Weight; abdominal fat; adiponectin; cardiovascular disorder risk; disorder risk; early childhood; epidemiologic data; infancy; inflammatory marker; insight; lifestyle factors; male; middle age; non-alcoholic fatty liver; novel; public health relevance; subcutaneous; vascular inflammation; waist circumference; young adult

DESCRIPTION (provided by applicant): The development of overweight/obesity, metabolic disorders, and the nature of their interrelationships over the lifespan, from early childhood throughout adulthood, is a problem with immense public health implications. Visceral obesity, through its metabolic association with vascular inflammation, hormonal disturbances, and insulin resistance, plays a unique role in the etiology of many chronic diseases. Recent studies have demonstrated potential mechanistic links between visceral fat accumulation and increased deposition of fat in the liver. Increased fat accumulation in the liver may lead to insulin resistance, dyslipidemia, and risk for CVD and T2DM. However, little is currently known about the natural progression of liver fat accumulation in normal healthy individuals. This proposed research will use both new and existing data from the Fels Longitudinal Study, a unique database that began in 1929. The Fels Longitudinal Study is the world's longest continuous serial study of growth, body composition and risk factors for chronic disease in randomly ascertained individuals. A major focus of this continuation proposal is the comprehensive assessment of the role of adipose tissue in cardiometabolic disease risk. Liver fat content and abdominal adipose tissue in several depots will be quantified by magnetic resonance imaging (MRI) in order to examine the interrelationships among liver fat, visceral and subcutaneous abdominal adiposity, and total body adiposity with respect to risk for cardiometabolic diseases. These data will be combined with existing data to test a variety of hypotheses by conducting both serial and cross-sectional analyses. There are four specific aims to the proposed continuation: 1) Elucidate the determinants of liver fat and abdominal adipose tissue (visceral, superficial and deep subcutaneous) accrual in Fels Longitudinal Study participants; 2) Elucidate associations and potential mechanistic pathways among different adipose tissue depots including the liver, abdomen (visceral, superficial and deep subcutaneous) and total body; 3) Elucidate relationships among different adipose tissue depots (including the liver, abdomen, and total body) and cardiometabolic risk; and 4) Elucidate relationships among patterns of change in body composition, traditional CVD and T2DM risk factors, systemic inflammatory factors, and adipocytokines during childhood and adulthood using long-term serial data. The data collected under this competitive renewal proposal will provide a better and more complete understanding of the physiological relationships among different adipose tissue depots and risk for cardiometabolic diseases such as non- alcoholic fatty liver disease, CVD, and T2DM. PUBLIC HEALTH RELEVANCE: The development of overweight/obesity is a problem in the United States with immense public health implications. This proposed research uses data from the Fels Longitudinal Study, a unique database that began in 1929, to examine the inter-relationships between obesity, liver fat accrual and chronic disease risk.

描述（由申请人提供）：从整个童年的幼儿期开始，超重/肥胖，代谢障碍及其相互关系的性质是巨大的公共卫生影响的问题。内脏肥胖通过其与血管炎症，荷尔蒙干扰和胰岛素抵抗的代谢相关性在许多慢性疾病的病因中起着独特的作用。最近的研究表明，内脏脂肪积累与肝脏中脂肪沉积增加之间的潜在机械联系。肝脏中脂肪的积累增加可能导致胰岛素抵抗，血脂异常以及CVD和T2DM的风险。但是，目前，关于正常健康个体的肝脏脂肪积累的自然进展知之甚少。这项拟议的研究将使用FELS纵向研究中的新数据和现有数据，这是一个独特的数据库，该数据库始于1929年。《 Fels纵向研究》是世界上对随机确定个体的慢性疾病的生长，身体组成和慢性疾病风险因素最长的连续序列序列研究。该延续建议的重点是对脂肪组织在心脏代谢疾病风险中的作用进行全面评估。肝脏脂肪含量和几个仓库中的腹部脂肪组织将通过磁共振成像（MRI）来量化，以检查肝脏脂肪，内脏和皮下腹部肥胖之间的相互关系，以及对心脏代余代替代疾病风险的总体脂肪。这些数据将与现有数据结合使用，以通过进行串行和横截面分析来检验各种假设。提出的延续有四个特定的目的：1）阐明在长石的纵向研究参与者中应计的肝脏脂肪和腹部脂肪组织（内脏，浅表和深层皮下）的决定因素； 2）阐明不同脂肪组织库之间的关联和潜在的机械途径，包括肝脏，腹部（内脏，浅表和深层皮下）和总体； 3）阐明不同脂肪组织库（包括肝脏，腹部和全身）和心脏代谢风险之间的关系； 4）使用长期序列数据，在儿童和成年期间，阐明身体成分，传统CVD和T2DM风险因素，全身性炎症因素以及脂肪细胞因子的关系之间的关系。在此竞争性更新建议下收集的数据将为不同的脂肪组织库之间的生理关系以及心脏代谢性疾病（例如非酒精脂肪脂肪肝疾病，CVD和T2DM）提供更好，更完整的了解。 公共卫生相关性：在美国具有巨大的公共卫生影响，超重/肥胖的发展是一个问题。这项拟议的研究使用了FELS纵向研究的数据，该数据始于1929年，它始于1929年，以检查肥胖，肝脏脂肪应计和慢性病风险之间的关系。