Neuroscience of Late-Life Depression, Social Perception, and Emotional Awareness

晚年抑郁症、社会感知和情绪意识的神经科学

• 批准号: 8252130
• 负责人: SERGIO PARADISO
• 金额: $ 15.34万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8252130
• 关键词: Adopted; Affect; Age; Aging; American; Anterior; Antidepressive Agents; Area; Atrophic; Awareness; Baby Booms; Base of the Brain; Biological; Blood Vessels; Body Weight decreased; Brain; Brain region; Cessation of life; Clinical; Cognitive; Congresses; Consensus; Data; Deformity; Depressed mood; Depressive disorder; Diagnosis; Disease; Doctor of Philosophy; Elderly; Emotional; Emotions; Empirical Research; Etiology; Face; Facial Expression; Facial Expression Perception; Feeling hopeless; Follow-Up Studies; Functional Magnetic Resonance Imaging; Future; Future Generations; Gender; General Population; Generations; Geriatric Psychiatry; Goals; Guilt; Health; Heart Diseases; High Prevalence; Housing; Image; Impaired cognition; Individual; Intervention; Intervention Studies; Investigation; Lesion; Link; Location; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Medial; Medical; Mental Depression; Mental disorders; Mentors; Mentorship; Methods; Moods; Neuroanatomy; Neurobehavioral Manifestations; Neurobiology; Neurofibrillary Tangles; Neurosciences; Pathologic Processes; Pathology; Patients; Perception; Performance; Personality; Persons; Plant Roots; Play; Policy Maker; Prefrontal Cortex; Prevalence; Prevention; Process; Psychiatry; Public Health; Reporting; Research; Research Personnel; Research Proposals; Resolution; Resources; Retirement; Risk; Risk Factors; Role; Screening procedure; Sex Characteristics; Sleeplessness; Social Change; Social Perception; Staging; Stimulus; Structure; Suicide; Symptoms; Syncope; Testing; Time; Training; Training Programs; United States National Institutes of Health; Withdrawal; Work; World Health; World Health Organization; affective neuroscience; age related; base; career; cerebral atrophy; cerebrovascular; cingulate cortex; depressive symptoms; disability; dysphoria; functional decline; functional disability; geriatric depression; healthy aging; ideation; improved; in vivo; instrument; interest; multidisciplinary; pleasure; programs; psychologic; psychosocial; relating to nervous system; remediation; self esteem; showing emotion; skills; social cognition; social health determinants; social neuroscience; suicide rate; suicide victim; symposium; tau Proteins; therapy development; tool; visual stimulus; white matter

DESCRIPTION (provided by applicant): In its fifty-eighth session concluded on May 25, 2005, The World Health Assembly adopted a resolution and formed a new Commission on Social Determinants of Health on strengthening and promoting healthy aging. More than one billion people will be over 60 years old by 2025 - the vast majority in the developing world - and this figure is expected to double by 2050. The World Health Organization has projected that depression will soon be second only to heart disease as a cause of disability. In late-life, the average prevalence for all depressive disorders is about 16%. Older depressed persons often fail to acknowledge sad mood or loss of pleasure, which may greatly contribute to inadequate diagnosis and treatment. The inability to perceive themselves as sad while suffering cognitive and vegetative symptoms of depression is possibly due to neuroanatomical age-related changes. In this application, the candidate, supported by outstanding resources and mentorship, proposes in Specific Aim # 1 to study social perception tasks known to engage limbic functioning, and emotional awareness and psychosocial adaptation in nondysphoric late-life depression. Perception of facial expression will be used in Specific Aim #2, as a probe to examine the functioning of limbic and medial prefrontal structures using functional magnetic resonance methods. We expect an overall reduced functioning of the limbic and medial prefrontal structures in nondysphoric depression which will constitute the basis for improved identification of the disorder. This research and a training plan include superb mentoring in social and affective neuroscience, magnetic resonance imaging, geriatric psychiatry, and neuroanatomy. This will enable the candidate to expand his thematic clinical and investigational interest on emotion processing and achieve his career goals: to improve the neurobiological understanding and recognition of late-life nondysphoric depression, to set the stage for a productive independent research career on longitudinal effects of deficits in social cognition and emotion on the phenomenology of psychiatric disorders in late-life, and open the way toward psychological and somatic intervention research. Depression in late-life is a significant public health problem that increases the risk of death by medical conditions or suicide; about one-half of all depressed older individuals are not diagnosed despite seeking medical help, perhaps due to some older people having poor ability to recognize their own emotions, including sad mood. As a consequence many depressed older people show the disorder's classic features including poor self-esteem and hopelessness, without the crucial "red flag" of low mood or loss of pleasure. The candidate and his multidisciplinary team of internationally recognized mentors seek to examine emotional awareness, perception of social stimuli, and the brain regions that are involved in these functions as indicators of older age depression-without-sadness, to uncover the brain bases for this debilitating psychiatric disorder, and improve its recognition and treatment.

描述（由申请人提供）：在2005年5月25日结束的第五十八届会议上，世界卫生大会通过了一项决议，并成立了一个新的关于加强和促进健康老龄化的健康社会决定因素委员会。到2025年，超过10亿人将超过60岁----其中绝大多数在发展中国家----预计到2050年这一数字将翻一番。世界卫生组织预测，抑郁症将很快成为仅次于心脏病的第二大致残原因。在晚年，所有抑郁症的平均患病率约为16%。老年抑郁症患者往往不承认悲伤的情绪或快乐的丧失，这可能大大有助于诊断和治疗不足。在遭受认知和植物性抑郁症状的同时，无法感知自己的悲伤可能是由于神经解剖学上与年龄相关的变化。在这个应用程序中，候选人，由优秀的资源和导师的支持，提出在具体目标#1研究社会知觉任务已知从事边缘功能，情绪意识和社会心理适应在非烦躁晚年抑郁症。面部表情的感知将用于具体目标#2，作为使用功能性磁共振方法检查边缘系统和内侧前额叶结构功能的探针。我们预计，在非焦虑抑郁症的边缘系统和内侧前额叶结构的整体功能下降，这将构成基础，以提高识别的障碍。这项研究和培训计划包括在社会和情感神经科学，磁共振成像，老年精神病学和神经解剖学方面的出色指导。这将使候选人能够扩大他对情绪处理的主题临床和研究兴趣，并实现他的职业目标：提高对晚年非焦虑抑郁症的神经生物学理解和认识，为社会认知和情感缺陷对晚年精神障碍现象学的纵向影响的富有成效的独立研究生涯奠定基础，并为心理和躯体干预研究开辟道路。老年抑郁症是一个重大的公共卫生问题，增加了因医疗条件或自杀而死亡的风险;尽管寻求医疗帮助，但大约一半的老年抑郁症患者没有被诊断出来，这可能是由于一些老年人识别自己情绪的能力较差，包括悲伤情绪。因此，许多抑郁的老年人表现出这种疾病的典型特征，包括缺乏自尊和绝望，而没有情绪低落或失去快乐的关键“红旗”。候选人和他的国际公认的导师的多学科团队寻求检查情绪意识，社会刺激的感知，以及参与这些功能的大脑区域作为老年抑郁症的指标-没有悲伤，以揭示这种使人衰弱的精神疾病的大脑基础，并改善其识别和治疗。

项目成果

Alexithymia in oncologic disease: association with cancer invasion and hemoglobin levels.

肿瘤疾病中的述情障碍：与癌症侵袭和血红蛋白水平的关联。

• 发表时间: 2011
• 期刊: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
• 作者: Messina,Antonino;Fogliani,AnnaMaria;Paradiso,Sergio
• 通讯作者: Paradiso,Sergio

The impact of atypical antipsychotic use on obstructive sleep apnea: a pilot study and literature review.

非典型抗精神病药物使用对阻塞性睡眠呼吸暂停的影响：一项试点研究和文献综述。

• DOI: 10.1016/j.sleep.2010.12.013
• 发表时间: 2011
• 期刊: Sleep medicine
• 影响因子: 4.8
• 作者: Shirani,Afshin;Paradiso,Sergio;Dyken,MarkEric
• 通讯作者: Dyken,MarkEric

Recognition of emotion from body language among patients with unipolar depression.

• DOI: 10.1016/j.psychres.2013.03.001
• 发表时间: 2013-08-30
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Loi F;Vaidya JG;Paradiso S
• 通讯作者: Paradiso S

Struggle for life, struggle for love and recognition: the neglected self in social cognitive neuroscience.

• DOI: 10.31887/dcns.2012.14.1/sparadiso
• 发表时间: 2012-03
• 期刊: Dialogues in clinical neuroscience
• 影响因子: 8.3
• 作者: Paradiso S;Rudrauf D
• 通讯作者: Rudrauf D

Beyond alcoholism: Wernicke-Korsakoff syndrome in patients with psychiatric disorders.

• DOI: 10.1097/wnn.0b013e31823f90c4
• 发表时间: 2011-12
• 期刊: Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
• 作者: McCormick LM;Buchanan JR;Onwuameze OE;Pierson RK;Paradiso S
• 通讯作者: Paradiso S