Administrative Core

为了运行一个连贯、协调和有效的计划项目，该计划的临床、研究、技术、数据库/统计和报告组成部分需要集中协调。计划项目的行政核心提供了计划项目核心和研究项目的组织结构和整合。另一个对成功至关重要的行政职能是与计划项目成功所依赖的其他研究计划的联系。在本计划项目中，所有受试者将从匹兹堡阿尔茨海默病研究中心（ADRC）或匹兹堡大学银杏记忆评估研究（GEMS）计划中招募。该计划项目行政核心将与ADRC的行政核心对接，ADRC现在已经成立25年，是一个大型且运作顺利的临床和基础研究实体。ADRC的组织结构是我们组织计划项目管理核心的模板，并且免费使用一些ADRC资源极大地促进了计划项目的运营。本计划项目的PI Klunk博士是ADRC的联合主任，ADRC主任洛佩斯博士是本计划项目的项目负责人，这极大地促进了这种互动。此外，Leslie Dunn担任ADRC和本计划项目的总管理员，在过去10年中，她一直是ADRC在GEMS赠款方面的联络人。本计划项目的管理与ADRC和GEMS的联系将优化本计划项目的受试者招募和保留。具体目标是：1）监督所有计划项目职能; 2）管理计划项目预算，包括根据计划项目优先级的支出和资金分配; 3）监督遵守联邦和大学政策和程序，如NIH公共访问政策，数据共享计划和人类受试者研究合规性; 4）对计划项目数据库的运作进行行政监督; 5）与匹兹堡大学阿尔茨海默病研究中心（ADRC）的神经病学系联络; 6）与匹兹堡大学银杏记忆研究评价（GEMS）的流行病学系工作人员联络。

To operate a cohesive, coordinated and effective Program Project, the clinical, research, technology, database/statistics and reporting components of the program require central coordination. The Administrative Core of the Program Project provides the organizational structure and integration of the Program Project Cores and research projects. Another administrative function critical for success is liaison with other research programs on which the Program Project relies for success. In the case of this Program Project, all subjects will be recruited from either the Pittsburgh Alzheimer's Disease Research Center (ADRC) or the University of Pittsburgh Gingko Evaluation of Memory Study (GEMS) program. The Program Project Administrative Core will interface with the Administrative Core of the ADRC, which is now in its 25th year and is a large and smoothly functioning clinical and basic research entity. The ADRC organizational structure serves as a template for our organization of the Program Project administrative core, and use of some ADRC resources at no cost to the Program Project greatly leverages the Program Project operations. Greatly facilitating this interaction is the fact that the PI of this Program Project, Dr. Klunk, is co-Director of the ADRC and the Director of the ADRC, Dr. Lopez, is a Project Leader on this Program Project. Furthermore, Leslie Dunn serves as overall Administrator for both the ADRC and this Program Project and she has been ADRC liaison on the GEMS grant over the past 10 years. The connections of the administration of this Program Project to the ADRC and GEMS will optimize the recruitment and retention of subjects into this Program Project. The specific aims are: 1) Supervision of all Program Project functions; 2) Management of the Program Project budget, including expenditures and allocation of funds according to Program Project priorities; 3) Monitor compliance with Federal and University policies and procedures, such as NIH Public Access Policy, Data Sharing Plan and Human Subjects Research compliance; 4) Administrative oversight of the functioning of the Program Project Database; 5) Liaison with the University of Pittsburgh Alzheimer's Disease Research Center (ADRC) in the Department of Neurology; and 6) Liaison with the University of Pittsburgh Gingko Evaluation of Memory Study (GEMS) staff in the Department of Epidemiology.