PPTOX III: Environmental Stressors in the Developmental Origins of Disease: Evide

PPTOX III：疾病发育起源中的环境压力源：证据

• 批准号: 8310382
• 负责人: Cheryl L. Walker
• 金额: $ 0.6万
• 依托单位: SOCIETY OF TOXICOLOGY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-14 至 2013-05-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8310382
• 关键词: Achievement; Animal Testing Alternatives; Applied Research; Award; Barker Hypothesis; Basic Science; Child; Child health care; Collaborations; Consensus; Data; Development; Diabetes Mellitus; Disease; Disease Outcome; Environmental Exposure; Environmental Health; Epidemiology; Epigenetic Process; European Union; Exposure to; Faeroe Islands; Fertilization; Florida; Fostering; Functional disorder; Funding; Gene Expression; Goals; Health; Health Policy; Human; Human Development; Immune System Diseases; Institutes; International; Learning; Life; Literature; Malignant Neoplasms; Modeling; Names; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; National Institute on Aging; Nutrient; Obesity; Oral; Paris, France; Participant; Policies; Postdoctoral Fellow; Regulation; Research; Research Personnel; Role; Science Policy; Scientist; Structure; Students; Toxicology; Travel; Work; animal data; base; body system; cost; design; disorder prevention; environmental chemical; environmental chemical exposure; environmental stressor; fetal; graduate student; human data; human disease; interest; meetings; metabolomics; nutrition; posters; prenatal; prevent; programs; reproductive; symposium; toxicant

DESCRIPTION (provided by applicant): PPTOX III is an international conference to be held May 14-16, 2012 in Paris, France. It will focus on the role of environmental exposures and nutrients during development on subsequent diseases/dysfunctions later in life. The goals of the conference are (1) to examine the animal and human data supporting this hypothesis (developmental basis of disease) in order to review the current state of the literature and to identify mechanisms for the effects; (2) to identify research gaps and challenges; (3) to integrate the basic and applied science; and (4) to impact science policy. As this is the only conference of its kind focused entirely on developmental programming integrating two fields (environmental chemical exposures and programming and altered nutrition and programming), it's unique structure offers leading researchers, students and postdoctoral fellows, to mention a few, a distinctive opportunity to attend and participate in the conference. Therefore, it is likely to hav a huge impact on the field itself and the development of a more integrated approach to disease prevention. The forthcoming conference will build on its earlier scope highlighting new, current issues such as the developmental basis of diabetes/obesity, immune dysfunction, cancer, and reproductive diseases/dysfunctions which are pertinent to the U.S. and globally. PPTOX III will also cover epigenetics, gene expression, metabolomics, and new methodological achievements as well as identifying new research gaps and challenges and integrating basic and applied science. To foster young researchers, oral presentation and poster sessions have been created and designed to highlight the research of graduate students and postdoctoral fellows. As such, the number of young participants relies upon the level of funding the conference receives. Travel Awards assist in offsetting the financial burden that might otherwise prevent students and postdoctoral fellows from attending and participating in conferences. The application also requests funds to partially defray travel costs for invited speakers. Speakers are provided lodging for two nights and travel expenses to and from the conference. It is necessary to assist with travel expenses for speakers, who provide cross-fertilization of ideas necessary for sustaining this world class conference. The distinct research topics and translational opportunities represented at the conference will be of interest not only to the National Institute f Child Health and Human Development (NICHD), but National Cancer Institute (NCI), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute on Aging (NIA), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute on Environmental Health Sciences (NIEHS) as well. PUBLIC HEALTH RELEVANCE: The proposed conference seeks to present front-line and up-to-date data on developmental programming and disease outcomes, to stimulate discussions and collaborations among and between experimental and epidemiological researchers and clinicians in regard to the influence of toxicants and nutrients on developmental programming, to provide a forum for students and postdoctorals to learn from and interact personally with experts in the fields, to define research gaps and needs, and finally to develop a consensus statement of where the field is and its impact on human health that will impact policy in the European Union, the USA and across the globe.

描述（由申请人提供）： PPTOX III 是将于2012 年5 月14-16 日在法国巴黎举行的国际会议。它将重点关注发育过程中环境暴露和营养物质对以后生活中随后的疾病/功能障碍的作用。会议的目标是（1）检查支持这一假设（疾病的发展基础）的动物和人类数据，以回顾文献的现状并确定其影响机制； (2) 找出研究差距和挑战； (3)整合 基础科学和应用科学； (4) 影响科学政策。由于这是同类会议中唯一一次完全专注于整合两个领域（环境化学暴露和编程以及改变营养和编程）的发展规划的会议，因此其独特的结构为领先的研究人员、学生和博士后研究员（仅举几例）提供了出席和参加会议的独特机会。因此，它可能对该领域本身以及更综合的疾病预防方法的发展产生巨大影响。即将举行的会议将在其早期范围的基础上强调当前的新问题，例如与美国和全球相关的糖尿病/肥胖、免疫功能障碍、癌症和生殖疾病/功能障碍的发展基础。 PPTOX III 还将涵盖表观遗传学、基因表达、代谢组学和新方法学成就，以及确定新的研究差距和挑战以及整合基础科学和应用科学。为了培养年轻研究人员，我们设立并设计了口头报告和海报会议，以突出研究生和博士后研究员的研究。因此，年轻参与者的数量取决于会议收到的资金水平。旅行奖励有助于抵消经济负担，否则可能会阻止学生和博士后研究员出席和参加会议。该申请还要求提供资金来支付受邀演讲者的部分旅费。为演讲者提供两晚的住宿以及往返会议的旅费。有必要为演讲者提供差旅费援助，他们为维持这一世界级会议提供了必要的思想交流。会议上提出的独特研究主题和转化机会不仅会引起国家儿童健康和人类发展研究所 (NICHD) 的兴趣，还会引起国家癌症研究所 (NCI)、国家过敏和传染病研究所 (NIAID)、国家老龄化研究所 (NIA)、国家心肺和血液研究所 (NHLBI) 和国家环境健康科学研究所 (NIEHS) 的兴趣。 出色地。 公共健康相关性：拟议的会议旨在提供有关发育规划和疾病结果的前沿和最新数据，促进实验和流行病学研究人员以及临床医生之间就毒物和营养素对发育规划的影响进行讨论和合作，为学生和博士后提供一个向该领域的专家学习并与专家进行个人互动的论坛，确定研究差距和需求，并最终制定一个 关于该领域的定位及其对人类健康影响的共识声明，这将影响欧盟、美国和全球的政策。