Training in Precision Environmental Health Sciences

精密环境健康科学培训

• 批准号: 10415181
• 负责人: Cheryl L. Walker
• 金额: $ 35.88万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415181
• 关键词: Environmental Health; Training

PROGRAM SUMMARY / ABSTRACT The interdisciplinary Training in Precision Environmental Health Sciences (TPEHS) program is a joint initiative of Baylor College of Medicine (BCM) and the University of Texas Health Science Center at Houston School of Public Health (UTH-SPH). Research at the intersection of genes and the environment (GxE) has contributed to the fields of environmental and public health and significantly advanced our knowledge of environmental factors and genetic contributors to disease. Genomics and environmental health research are producing ever-larger data sets, illuminating the need for today's environmental health researchers to be able to incorporate big data into their research. The goal of the TPEHS is to train the next generation of environmental health scientists working at the interface of genetics, environmental health and data science (GxExD). The training program is aligned with the Center for Precision Environmental Health at BCM, led by Program Director Dr. Cheryl Walker. This Center provides strong institutional support for the TPEHS and a “home base” for this joint training program. TPEHS Program Objectives are for trainees to 1) acquire fundamental knowledge in Genetics, Environmental Health, and Data Science; 2) become proficient at integrating concepts of GxExD into research; and 3) gain the necessary skills and tools to leverage GxExD training to achieve their next career objective. The Program will support 2 pre- and 2-post-doctoral trainees in Year 1, increasing to 3 pre- and 3 post-doctoral trainees/year thereafter. The core curriculum for PhD students includes didactic coursework in Environmental Health/Toxicology, Genetics, and Data Science and a Foundations Course on Integrative Concepts of Precision Environmental Health. This didactic training is complemented by career development activities, training in Responsible Conduct of Research and Rigor and Reproducibility, and programmatic/networking opportunities (including peer-to-peer mentoring) that enhance the training environment and build cohesion among trainees. In addition to the Foundations Course, postdoctoral training includes the opportunity for industry-based networking with the Health and Environmental Sciences Institute (HESI) and/or preparation for academic careers via grant- writing workshops and submission of a K99/R00 application. Leadership at both BCM and UTH-SPH have committed to providing four additional slots for trainees in the Program, increasing the size of the trainee cohort and broadening the applicant pool beyond US citizens. The TPEHS is a unique opportunity to cross-train biomedical scientists in GxExD research and leverage the collaborative environment and research powerhouse of the Texas Medical Center scientific community. At the end of the program, trainees will have a deep understanding of inter-disciplinary GxExD research, demonstrated ability to carry out independent research in this challenging multidisciplinary area, and the preparation needed be effective precision environmental health researchers of tomorrow.

节目摘要/摘要 精密环境健康科学(TPEHS)计划的跨学科培训是一项联合倡议 贝勒医学院(BCM)和德克萨斯大学休斯顿分校健康科学中心 公共卫生(UTH-SPH)。基因和环境(GxE)交叉点的研究为 环境和公共卫生领域，极大地提高了我们对环境因素的认识 以及导致疾病的基因因素。基因组学和环境健康研究正在产生越来越大的 数据集，说明了今天的环境健康研究人员需要能够整合大数据 投入他们的研究。TPEHS的目标是培养下一代环境健康科学家 从事遗传学、环境健康和数据科学(GxExD)的工作。培训计划是 与BCM的精密环境健康中心保持一致，由项目主任谢丽尔·沃克博士领导。 该中心为TPEHS提供了强有力的制度支持，并为这一联合培训计划提供了一个“大本营”。 TPEHS计划的目标是让学员1)获得遗传学、环境方面的基础知识 健康和数据科学；2)熟练地将GxExD的概念整合到研究中；3)获得 利用GxExD培训实现下一个职业目标所需的技能和工具。该计划将 在第一年支持2名博士后和2名博士后实习生，增加到每年3名博士后和3名博士后实习生 之后。面向博士生的核心课程包括环境教学课程 健康/毒理学、遗传学和数据科学以及精确度综合概念基础课程 环境卫生。这种教学培训与职业发展活动相辅相成，培训 负责任地进行研究、严谨和可重复性，以及方案/网络机会 (包括点对点辅导)，以改善培训环境并在受训者之间建立凝聚力。在……里面 除了基础课程，博士后培训还包括基于行业的网络机会 与健康和环境科学研究所(HESI)合作和/或通过拨款为学术生涯做准备- 写作工作坊和提交K99/R00申请。BCM和UTH-SPH的领导层都有 承诺为方案中的受训人员提供四个额外的名额，增加受训人员队伍的规模 并扩大了美国公民以外的申请者群体。TPEHS是交叉培训的独特机会 生物医学科学家参与GxExD研究并利用协作环境和研究动力 德克萨斯医学中心科学界的。在节目结束时，实习生将深入了解 了解跨学科的GxExD研究，有能力在以下领域开展独立研究 这是一个具有挑战性的多学科领域，需要做好有效的环境卫生精准准备工作 未来的研究人员。

项目成果

Characteristics and predictors of intensive care unit admission in pediatric blunt abdominal trauma.

小儿钝性腹部创伤的重症监护病房的特征和预测指标。

• DOI: 10.1007/s00383-022-05067-5
• 发表时间: 2022-04
• 期刊: PEDIATRIC SURGERY INTERNATIONAL
• 影响因子: 1.8
• 作者: Mehl, Steven C.;Cunningham, Megan E.;Streck, Christian J.;Pettit, Rowland;Huang, Eunice Y.;Santore, Matthew T.;Tsao, Kuojen;Falcone, Richard A.;Dassinger, Melvin S.;Haynes, Jeffrey H.;Russell, Robert T.;Naik-Mathuria, Bindi J.;St Peter, Shawn D.;Mooney, David;Upperman, Jeffrey;Blakely, Martin L.;Vogel, Adam M.
• 通讯作者: Vogel, Adam M.

FKBP8 variants are risk factors for spina bifida.

• DOI: 10.1093/hmg/ddaa211
• 发表时间: 2020-09
• 期刊: Human molecular genetics
• 影响因子: 3.5
• 作者: T. Tian;Xuanye Cao;Sung-Eun Kim;Y. Lin;J. Steele;Robert M. Cabrera;Menuka Karki;Wei Yang;N. J. Marini;Ethan N Hoffman;Xiao Han;Cindy X. Hu;Linlin Wang;B. Wlodarczyk;G. Shaw;A. Ren;R. Finnell;Y. Lei

Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects.

• DOI: 10.3389/fcell.2022.832492
• 发表时间: 2022
• 期刊: Frontiers in cell and developmental biology
• 影响因子: 5.5
• 作者: Steele JW;Lin YL;Chen N;Wlodarczyk BJ;Chen Q;Attarwala N;Venkatesalu M;Cabrera RM;Gross SS;Finnell RH
• 通讯作者: Finnell RH

Association of red blood cell transfusion volume with postoperative complications and mortality in neonatal surgery.

• DOI: 10.1016/j.jpedsurg.2021.12.025
• 发表时间: 2022-11
• 期刊: JOURNAL OF PEDIATRIC SURGERY
• 影响因子: 2.4
• 作者: Mehl, Steven C.;Portuondo, Jorge, I;Pettit, Rowland W.;Fallon, Sara C.;Wesson, David E.;Massarweh, Nader N.;Shah, Sohail R.;Lopez, Monica E.;Vogel, Adam M.
• 通讯作者: Vogel, Adam M.

Artificial intelligence, machine learning, and deep learning for clinical outcome prediction.

• DOI: 10.1042/etls20210246
• 发表时间: 2021-12-20
• 期刊: Emerging topics in life sciences
• 影响因子: 3.8
• 作者: Pettit RW;Fullem R;Cheng C;Amos CI
• 通讯作者: Amos CI