Calcium Supplementation In Pregnancy To Prevent Preeclampsia

孕期补钙预防先兆子痫

• 批准号: 8553839
• 负责人: Edwina Yeung
• 金额: $ 6.52万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553839
• 关键词: Angiogenic Factor; Biological; Biological Markers; Calcium; Cells; DNA; Databases; Etiology; Gestational Diabetes; Incidence; Investigation; Learning; Neonatal; Obesity; Participant; Pathogenesis; Placebos; Pre-Eclampsia; Pregnancy; Prevention; Publications; Randomized; Research; Risk; Risk Factors; Sampling; Severities; Specimen; Supplementation; Thyroid Hormones; Woman; Work; novel; pregnant; prevent; repository

4589 healthy nulliparous women who were 13 to 21 weeks pregnant were randomly assigned to receive daily treatment with either 2g of elemental calcium or placebo for the remainder of their pregnancies in1992-1995. Calcium supplementation did not significantly reduce the incidence or severity of preeclampsia or delay its onset. In subsequent analysis, the biological samples stored from the trial have been used to determine the associations between angiogenic factors, cell free DNA, thyroid hormone, and other biomarkers on the risk of developing preeclampsia. Other publications have also identified additional risk factors and consequences of preeclampsia with few investigations regarding gestational diabetes. Dr. Richard Levine is the original PI for the study and led numerous investigations using the biospecimens collected from CPEP to investigate the etiology of preeclampsia. After Dr. Levine's passing, Dr. Yeung has been continuing this work. Additional analyses utilizing the study database and specimen repository are being performed.

在1992 -1995年，4589名怀孕13 - 21周的健康初产妇被随机分配在剩余的妊娠期内每天服用2g元素钙或安慰剂。钙补充剂并没有显著降低先兆子痫的发生率或严重程度，也没有延迟其发作。 在随后的分析中，从试验中储存的生物样本已被用于确定血管生成因子，无细胞DNA，甲状腺激素和其他生物标志物之间的关联，发展先兆子痫的风险。 其他出版物也确定了额外的危险因素和先兆子痫的后果，很少有关于妊娠糖尿病的调查。Richard Levine博士是该研究的原始PI，并使用从CPEP收集的生物标本进行了大量研究，以研究先兆子痫的病因。 李文博士去世后，杨博士一直在继续这项工作。 正在利用研究数据库和标本库进行其他分析。