Scientific Core: Acquisition, Synthesis, and Characterization of Nanomaterials

科学核心：纳米材料的获取、合成和表征

• 批准号: 8274478
• 负责人: Jeffrey I Zink
• 金额: $ 24.55万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8274478
• 关键词: Biological; Caliber; Charge; Chemicals; Cobalt; Copper; Data; Encapsulated; Engineering; Equus caballus; Fluorescence; Gatekeeping; Goals; Gold; Hand; In Vitro; Ions; Kilogram; Libraries; Lung; Manufacturer Name; Measurement; Measures; Metals; Methods; Molecular; Outcome; Property; Research; Research Activity; Services; Shapes; Shipping; Ships; Silicon Dioxide; Silver; Structure; Surface; Testing; Titania; Titanium; Toxic effect; Toxicology; Zinc Oxide; base; cell injury; chemical property; design; fluorescence imaging; fundamental research; in vivo; medical specialties; metal oxide; nano; nanobiology; nanomachine; nanomaterials; nanoparticle; particle; physical property; programs; research study; response; retinal rods

The scientific core is responsible for all of the particles that will be studied in the center. These responsibilities include thorough chemical and physical characterization of all particles, synthesizing new particles for the purposes of completing libraries and for introducing new functionality such as fluorescence, and designing and synthesizing highly specialized particles that will be used to test hypotheses arising from the in vitro and in vivo biological studies about injurious effects at the nano-bio interface. Accurate, thorough and interpretable characterization of Engineered Nanomaterial (ENM) libraries (Table 1) is an absolute necessity for studies of pulmonary toxicity. The physical and chemical properties must be delineated in order to provide a basis for interpreting molecular and cellular injury mechanisms. Manufacturers' statements about the properties of the materials that they ship provide varying degrees of completeness and accuracy. The Scientific Core will carry out all of its own measurements (see section IB) and provide reliable data in a uniform arid interpretable fonnat to the project leaders.

科学核心负责将在该中心研究的所有粒子。这些职责包括对所有颗粒进行彻底的化学和物理表征，合成新颗粒以完成库和引入荧光等新功能，以及设计和合成高度专业化的颗粒，这些颗粒将用于测试体外和体内生物学研究中关于纳米生物界面有害影响的假设。工程纳米材料 (ENM) 库（表 1）的准确、彻底和可解释的表征对于肺毒性研究是绝对必要的。必须描述物理和化学特性，以便为解释分子和细胞损伤机制提供基础。制造商关于属性的声明 他们提供的材料提供了不同程度的完整性和准确性。科学核心将进行自己的所有测量（参见 IB 部分），并以统一且可解释的格式向项目负责人提供可靠的数据。