Scientific Core: Acquisition, Synthesis, and Characterization of Nanomaterials

科学核心负责中心将研究的所有粒子。这些职责包括对所有颗粒进行彻底的化学和物理表征，为了完善文库和引入新功能(如荧光)而合成新颗粒，以及设计和合成高度专业化的颗粒，这些颗粒将用于测试体外和体内关于纳米生物界面损伤效应的生物学研究产生的假说。对工程纳米材料(ENM)文库的准确、彻底和可解释的表征(表1)对于肺毒性研究是绝对必要的。必须描述其物理和化学性质，以便为解释分子和细胞损伤机制提供基础。制造商关于该产品特性的声明 他们运送的材料提供了不同程度的完整性和准确性。科学核心将进行自己的所有测量(见IB节)，并以统一和可解释的格式向项目负责人提供可靠的数据。

The scientific core is responsible for all of the particles that will be studied in the center. These responsibilities include thorough chemical and physical characterization of all particles, synthesizing new particles for the purposes of completing libraries and for introducing new functionality such as fluorescence, and designing and synthesizing highly specialized particles that will be used to test hypotheses arising from the in vitro and in vivo biological studies about injurious effects at the nano-bio interface. Accurate, thorough and interpretable characterization of Engineered Nanomaterial (ENM) libraries (Table 1) is an absolute necessity for studies of pulmonary toxicity. The physical and chemical properties must be delineated in order to provide a basis for interpreting molecular and cellular injury mechanisms. Manufacturers' statements about the properties of the materials that they ship provide varying degrees of completeness and accuracy. The Scientific Core will carry out all of its own measurements (see section IB) and provide reliable data in a uniform arid interpretable fonnat to the project leaders.