Scientific Core: Acquisition, Synthesis, and Characterization of Nanomaterials

科学核心负责所有将在中心研究的粒子。这些职责包括对所有颗粒进行彻底的化学和物理表征，为完成文库和引入荧光等新功能而合成新颗粒，以及设计和合成高度专业化的颗粒，这些颗粒将用于测试纳米生物界面上有害效应的体外和体内生物学研究中产生的假设。准确、全面和可解释的工程纳米材料（ENM）文库表征（表1）对于肺毒性研究是绝对必要的。物理和化学性质必须划定，以便为解释分子和细胞损伤机制提供基础。制造商关于产品特性的声明

The scientific core is responsible for all of the particles that will be studied in the center. These responsibilities include thorough chemical and physical characterization of all particles, synthesizing new particles for the purposes of completing libraries and for introducing new functionality such as fluorescence, and designing and synthesizing highly specialized particles that will be used to test hypotheses arising from the in vitro and in vivo biological studies about injurious effects at the nano-bio interface. Accurate, thorough and interpretable characterization of Engineered Nanomaterial (ENM) libraries (Table 1) is an absolute necessity for studies of pulmonary toxicity. The physical and chemical properties must be delineated in order to provide a basis for interpreting molecular and cellular injury mechanisms. Manufacturers' statements about the properties of the materials that they ship provide varying degrees of completeness and accuracy. The Scientific Core will carry out all of its own measurements (see section IB) and provide reliable data in a uniform arid interpretable fonnat to the project leaders.