Extension of Combination Therapy for Multiple Sclerosis
Extension of Combination Therapy for Multiple Sclerosis
批准号:
8374682
负责人:
FRED D LUBLIN
金额:
$25.0万
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-09-30 至 2015-11-30
关键词:
Biological MarkersBlindedClinical TrialsCollectionCombined Modality TherapyConsultationsData AnalysesDouble-Blind MethodEnrollmentFundingGoalsGrantInterferon-betaInterferonsMultiple SclerosisNational Institute of Neurological Disorders and StrokeNorth AmericaOutcome MeasurePatientsPlacebo ControlPlacebosProtocols documentationRandomizedRelapseResearch DesignResearch MethodologyResearch PersonnelScheduleSiteTestingTherapeutic Agentsarmbaseclinical research sitecopolymer 1follow-upimprovedprimary outcomeprograms
中文摘要
CombiRx临床试验是一项随机、双盲、安慰剂对照、多中心随机研究,比较干扰素- β -la (IFN)和醋酸格拉替默(GA)联合作为复发-缓解型多发性硬化症(RR MS)的主要治疗药物的疗效。该研究所赞助项目的最初资金是在2003年11月。最初要求为北美各地的40个临床站点提供资金。在获得资金后,并根据同国家发展和开发计划署方案工作人员的协商,计划的地点数目增加到80个,以改善征聘工作。招募目标是1000名受试者,随机抽取50%
英文摘要
The CombiRx clinical trial is a randomized, double blind, placebo controlled, multi-center randomized study of the efficacy of combining interferon beta-la (IFN) and glatiramer acetate (GA) compared to either agent alone as primary therapy for relapsing-remitting MS (RR MS). The original funding of this NINDS sponsored project was in November 2003. Initially funding was requested for 40 clinical sites across North America. After funding, and based on consultation with NINDS program staff, the number of planned sites was increased to a target of 80 to improve recruitment. The recruitment goal is 1000 subjects, randomized 50%
to combination therapy and 25% to each single therapeutic agent with a matched placebo. This application is for renewal of this grant to complete the follow up of all patients through three years on study protocol. The primary outcome and other outcome measures are unchanged from the original protocol. The extension plan, which is to follow all subjects in their original study arm until the last subject has completed all three years of the study, has been approved by the study DSMB as well as the investigators.
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专著(0)
科研奖励(0)
会议论文
MRI predictors of disease and disability progression in African Americans with multiple sclerosis
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批准号:10224347
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项目类别:
-
资助金额:$51.87万
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财政年份:2017
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负责人:FRED D LUBLIN
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依托单位:
Extension of Combination Therapy for Multiple Sclerosis
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批准号:8042557
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项目类别:
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资助金额:$850.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Extension of Combination Therapy for Multiple Sclerosis (eCombiRx)
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批准号:8215669
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项目类别:
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资助金额:$25.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Extension of Combination Therapy for Multiple Sclerosis (eCombiRx)
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批准号:8042558
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项目类别:
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资助金额:$25.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Combination Therapy in Multiple Sclerosis
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批准号:7037603
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项目类别:
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资助金额:$569.88万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Extension of Combination Therapy for Multiple Sclerosis
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批准号:7943151
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项目类别:
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资助金额:$1010.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Combination Therapy in Multiple Sclerosis
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批准号:6807036
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项目类别:
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资助金额:$383.46万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Combination Therapy in Multiple Sclerosis
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批准号:7350181
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项目类别:
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资助金额:$909.05万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Combination Therapy in Multiple Sclerosis
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批准号:6731800
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项目类别:
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资助金额:$700.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Extension of Combination Therapy for Multiple Sclerosis (eCombiRx)
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批准号:7527525
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项目类别:
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资助金额:$1010.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Extension of Combination Therapy for Multiple Sclerosis
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批准号:8214725
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项目类别:
-
资助金额:$25.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Combination Therapy in Multiple Sclerosis
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批准号:7222694
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项目类别:
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资助金额:$0.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Extension of Combination Therapy for Multiple Sclerosis (eCombiRx)
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批准号:7862341
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项目类别:
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资助金额:$850.0万
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财政年份:2003
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负责人:FRED D LUBLIN
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依托单位:
Combination Therapy in Multiple Sclerosis
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批准号:6364449
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项目类别:
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资助金额:$24.74万
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财政年份:2001
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负责人:FRED D LUBLIN
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依托单位:
BRAIN TRANSPLANTS IN GENETIC ANALYSIS
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批准号:3406170
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项目类别:
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资助金额:$12.2万
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财政年份:1986
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负责人:FRED D LUBLIN
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依托单位:
BRAIN TRANSPLANTS IN GENETIC ANALYSIS
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批准号:3406167
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项目类别:
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资助金额:$11.44万
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财政年份:1986
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负责人:FRED D LUBLIN
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依托单位:
BRAIN TRANSPLANTS IN GENETIC ANALYSIS
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批准号:3406169
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项目类别:
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资助金额:$12.51万
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财政年份:1986
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负责人:FRED D LUBLIN
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依托单位:
海外基金