MAINTAINANCE OF AN SPF MACAQUE BREEDING COLONY FOR AIDS RESEARCH: AIDS

维持 SPF 猕猴繁殖群以进行艾滋病研究：艾滋病

• 批准号: 8356919
• 负责人: JAMES L BLANCHARD
• 金额: $ 100.36万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356919
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Award; Breeding; Country; Funding; Goals; Grant; Income; Infant; Macaca; Macaca mulatta; Monitor; Monkeys; National Center for Research Resources; Primates; Principal Investigator; Process; Production; Protocols documentation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Sales; Source; Specific Pathogen Frees; United States National Institutes of Health; Viral; cost; germ free condition; meetings; programs; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Tulane National Primate Center (TNPRC) has one of the largest rhesus monkey breeding colonies in the US. This resource has provided animals for NIH funded research projects for several decades and is a critical component of the Center's successful research program. Because over half of all projects at TNPRC are initiated by outside investigators, this resource is also essential to the success of many NIH-funded investigators throughout the country. Several years ago TNPRC established the goal of having only specific pathogen free (SPF) monkeys at the Center. A major step toward that goal was the award of this U42 grant in 2001 to provide funds to establish an SPF Indian-origin rhesus monkey colony at TNPRC to provide monkeys for NIH-funded AIDS research. Approximately 800 animals were recruited into the U42 funded SPF colony in the first four years. The colony is expected to increase in number to 1,000 animals by the end of the last year of the current grant, meeting the goal of the original application. The objective of this application is to request funds to support an average of 900 SPF rhesus monkeys and to continue to monitor the viral status of the colony for the next 5 years. The plan is to maintain the colony at a level that will allow production of at least 300 infants each year. This will provide at least 150 animals for assignment to NIH-funded AIDS research protocols and 150 for replacement breeders. Beginning in year 2, revenue from animal sales will be returned to the grant as program income. This will begin the process of transition to a self-sustaining colony, which will be achieved by the end of the grant period.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（由申请人提供）：杜兰国家灵长类动物中心（TNPRC）拥有美国最大的恒河猴繁殖群之一。几十年来，该资源为NIH资助的研究项目提供了动物，是该中心成功研究计划的关键组成部分。由于TNPRC的所有项目中有一半以上是由外部研究人员发起的，因此这种资源对于全国许多NIH资助的研究人员的成功也至关重要。几年前，TNPRC确立了在中心只提供无特定病原体（SPF）猴子的目标。实现这一目标的一个重要步骤是2001年授予U42赠款，为在TNPRC建立一个SPF印度恒河猴群提供资金，为NIH资助的艾滋病研究提供猴子。在最初的四年里，大约有800只动物被招募到U42资助的SPF群体中。到目前赠款的最后一年年底，殖民地的动物数量预计将增加到1,000只，达到最初申请的目标。本申请的目的是申请资金，以支持平均900只SPF恒河猴，并在未来5年内继续监测殖民地的病毒状况。计划是将殖民地维持在每年至少能生产300名婴儿的水平。这将提供至少150只动物分配给NIH资助的艾滋病研究方案，150只用于替代育种者。从第二年开始，动物销售收入将作为项目收入返还给赠款。这将开始过渡到一个自我维持的殖民地的进程，这将在赠款期结束时实现。