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Understanding the role of RAD51C complexes in recombination and repair

Understanding the role of RAD51C complexes in recombination and repair
了解 RAD51C 复合物在重组和修复中的作用
批准号：
8371419
负责人：
Yilun Liu
金额：
$24.4万
依托单位：
BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-09-01 至 2013-07-31
来源：
https://reporter.nih.gov/project-details/8371419
关键词：
BRCA2 geneBiochemicalCancer PatientCell LineCellsChromosome abnormalityChromosomesCleaved cellComplexCruciform DNACytotoxic ChemotherapyDNADNA DamageDNA Interstrand CrosslinkingDNA RepairDNA StructureDNA repair proteinDataDevelopmentDissociationDouble Strand Break RepairE coli RecA proteinERCC1 geneEmbryoEnsureEventExhibitsFamilyFibroblastsGenetic RecombinationGenomeGoalsHolliday Junction ResolvasesHomologous GeneHumanHypersensitivityIn VitroKnock-outKnowledgeLeadLinkMaintenanceMalignant NeoplasmsMammalian CellMediatingMediator of activation proteinMusMutationNonhomologous DNA End JoiningNucleotide Excision RepairPathway interactionsPharmaceutical PreparationsPlayProcessProteinsRAD51C geneRadiation therapyRecruitment ActivityRegulationResearchResolutionRoleSiteStagingVertebratesXRCC2 geneXRCC3 genecancer riskcancer therapycell transformationchemotherapycrosslinkds-DNAendonucleasehelicasehomologous recombinationinsightmutantneoplastic cellnovelparalogous genepolypeptidepreventprotein complexprotein protein interactionpublic health relevancerecombinaserecombinational repairrepaired

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