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The molecular basis of RECQ4-associated genetic disorders and cancer predispositi

The molecular basis of RECQ4-associated genetic disorders and cancer predispositi
RECQ4相关遗传性疾病和癌症易感性的分子基础
批准号：
8371475
负责人：
Yilun Liu
金额：
$26.34万
依托单位：
BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-03-01 至 2016-02-29
来源：
https://reporter.nih.gov/project-details/8371475
关键词：
Aging-Related ProcessAllelesAmino AcidsBacteriaBindingBiochemicalCDC45L geneCatalytic DomainCell CycleCell ExtractsCell ProliferationCell SurvivalCellsChromatinCircadian RhythmsCisplatinComplexCyclin-Dependent KinasesDNADNA BindingDNA DamageDNA RepairDNA Replication FactorDNA StructureDNA biosynthesisDataDefectDevelopmentDiseaseDissociationEukaryotaEvolutionFamilyG1 PhaseGenesGenomeGenomic InstabilityGenomicsGenotoxic StressGoalsHealthHereditary DiseaseHomologous GeneHumanIn VitroIndividualIonizing radiationKnowledgeLeadLesionLinkLymphomaMCM10 geneMCM2 geneMaintenanceMalignant NeoplasmsMapsMethodsMolecularMolecular AnalysisMutagenesisMutationOrganismOutcomePathogenesisPatientsPhenotypePhosphorylationPredispositionPremature aging syndromeProcessProkaryotic CellsPropertyProtein FamilyProteinsRECQL4 geneRegulationReplication InitiationReplication OriginReportingRoleSet proteinSister ChromatidTumor Suppressor ProteinsVertebratesWorkYeastsarmbasebiological adaptation to stresscancer preventioncancer therapycell growthclinical phenotypecohesionhelicasein vitro activityin vivometaplastic cell transformationmouse modelosteosarcomapolypeptidepreventprotein complexprotein protein interactionpublic health relevancerepairedtumorigenesis

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