Cyclooxygenase-2 Regulation of Blood-Brain Barrier Opening in Ischemic Stroke

环氧合酶 2 对缺血性中风血脑屏障开放的调节

• 批准号: 8366616
• 负责人: Eduardo Jesus Candelario-Jalil
• 金额: $ 29.57万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8366616
• 关键词: Ablation; Acute; Aftercare; Binding; Blood - brain barrier anatomy; Brain; Brain Diseases; Brain Edema; Brain Injuries; Brain Ischemia; Cardiovascular system; Cell Death; Cells; Cerebral Ischemia; Cerebrum; Cessation of life; Clinical; Coxibs; Data; Dinoprostone; Dose; EP4 receptor; Edema; Event; Gelatinase A; Gelatinase B; Gene Deletion; Genes; Genetic; Goals; Hour; Human; Infarction; Infiltration; Inflammation; Inflammation Mediators; Injury; Ischemia; Ischemic Stroke; Knock-out; Leukocytes; Link; Long-Term Effects; Magnetic Resonance Imaging; Matrix Metalloproteinases; Mediating; Modeling; Molecular Target; Nervous System Physiology; Neurologic; Neurological outcome; Neuronal Injury; Neurons; Nimesulide; Pathway interactions; Pharmaceutical Preparations; Phase; Production; Prostaglandin-Endoperoxide Synthase; Prostaglandins; Prostaglandins I; Proteins; Rattus; Regulation; Role; Signal Pathway; Signal Transduction; Stroke; Stromelysin 1; Testing; Therapeutic; Therapeutic Studies; Tight Junctions; Time; Toxic effect; attenuation; brain tissue; cyclooxygenase 2; design; improved; in vivo; neoplastic cell; neuroinflammation; neuroprotection; neurotoxicity; novel; prostaglandin EP2 receptor; prostanoid receptor EP1; protein degradation; public health relevance; receptor; research study; stroke therapy