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Myostatin Family Signaling in Burn-Injury Related Muscle Wasting

Myostatin Family Signaling in Burn-Injury Related Muscle Wasting
烧伤相关肌肉萎缩中的肌肉生长抑制素家族信号传导
批准号：
8366782
负责人：
Teresa A Zimmers
金额：
$26.48万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-08-01 至 2015-05-31
来源：
https://reporter.nih.gov/project-details/8366782
关键词：
ACVR2B geneAdipose tissueBinding ProteinsBiologicalBiological AssayBody CompositionBody Surface AreaBurn CentersBurn injuryCachexiaCaliberCanis familiarisCatabolismCattleCellsCessation of lifeChildChronicChronic DiseaseClinicalClinical ResearchCollaborationsComplexCountryDataDetectionDevelopmentDiseaseDistantDominant Negative ReceptorDominant-Negative MutationElectroporationExhibitsFamilyFatty acid glycerol estersFiberFollistatinFutureGene ExpressionGene TargetingGene TransferGenesGeneticGenetic ModelsGoalsGrowthGrowth InhibitorsHepatosplenomegalyHumanHyperplasiaHypertrophyIndividualInfectionInflammationInjuryInsulin ResistanceInterventionIntramuscular InjectionsKnockout MiceLifeLigandsMADH2 geneMeasuresMediatingMessenger RNAModelingMolecularMusMuscleMuscle ProteinsMutationOrganPathway interactionsPatientsPeptide HydrolasesPhysiologyPlasmaPlasmidsPrincipal InvestigatorProcessProteinsProteolysisProto-Oncogene Proteins c-aktQuality of lifeRNAReagentReceptor ActivationRecoveryRegulationRegulator GenesRelative (related person)RepressionRoleScientistSignal PathwaySignal TransductionSiteSkeletal MuscleSpeedSurgeonTestingTherapeuticThickTransforming Growth FactorsTransgenic MiceTransgenic OrganismsTranslatingWound Healingdata modelingdesigngenetic regulatory proteinimprovedinhibitor/antagonistinnovationinsightinterestmembermortalitymouse modelmultidisciplinarymuscle formmyostatinnovelpreclinical studyprofessorpublic health relevancereceptorreceptor bindingresponsesatellite cellskeletal muscle wastingtherapeutic targettranslational studywasting

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