The Role of Interleukin-2 in Vascular Smooth Muscle Cell Homeostasis

IL-2 在血管平滑肌细胞稳态中的作用

• 批准号: 8366666
• 负责人: Lucile E Wrenshall
• 金额: $ 9万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-12 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8366666
• 关键词: Actins; Address; Affect; Aneurysm; Apoptosis; Arterial Fatty Streak; Arteries; Atherosclerosis; Binding; Biological Assay; Biology; Blood Vessels; Bypass; Carbohydrates; Cardiovascular Diseases; Cell Proliferation; Cell physiology; Cells; Cellular biology; Cessation of life; Chemistry; Country; Development; Digestion; Disease; Drug Delivery Systems; Dyes; Enzymes; Exhibits; Failure; Functional disorder; Future; Generations; Goals; Heparitin Sulfate; Homeostasis; Human; Human Pathology; Hyperplasia; Immunology; Impairment; Individual; Interleukin-2; Knockout Mice; Knowledge; Label; Laboratories; Lead; Learning; Location; Lymphocyte; Maintenance; Measures; Mission; Modeling; Morphology; Mus; Oligosaccharides; Operative Surgical Procedures; Organ Transplantation; Pathologic; Pathology; Pathway interactions; Phenotype; Play; Prevalence; Prevention; Process; Proteoglycan; Public Health; Qualifying; Reagent; Regulation; Research; Role; Rupture; Shapes; Smooth Muscle Myocytes; Specimen; Testing; Therapeutic; Therapeutic Intervention; Tissues; Transplantation; United States; Vascular Diseases; Veins; Venous; Western Blotting; Work; base; design; heparanase; human disease; human tissue; in vivo; inhibitor/antagonist; innovation; insight; mortality; novel; novel therapeutics; polysulfated glycosaminoglycan; prevent; public health relevance; response; restenosis; therapeutic development; therapy design; vascular smooth muscle cell proliferation

项目成果

Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues.

• DOI: 10.1371/journal.pone.0102191
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wrenshall LE;Clabaugh SE;Cool DR;Arumugam P;Grunwald WC;Smith DR;Liu GC;Miller JD
• 通讯作者: Miller JD

Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase.

• DOI: 10.1038/icb.2011.45
• 发表时间: 2012-02
• 期刊: IMMUNOLOGY AND CELL BIOLOGY
• 影响因子: 4
• 作者: Miller, John D.;Clabaugh, Suzanne E.;Smith, Deandra R.;Stevens, R. Brian;Wrenshall, Lucile E.
• 通讯作者: Wrenshall, Lucile E.