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The Role of Interleukin-2 in Vascular Smooth Muscle Cell Homeostasis

The Role of Interleukin-2 in Vascular Smooth Muscle Cell Homeostasis
IL-2 在血管平滑肌细胞稳态中的作用
批准号：
8366666
负责人：
Lucile E Wrenshall
金额：
$9.0万
依托单位：
WRIGHT STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-04-12 至 2013-03-31
来源：
https://reporter.nih.gov/project-details/8366666
关键词：
ActinsAddressAffectAneurysmApoptosisArterial Fatty StreakArteriesAtherosclerosisBindingBiological AssayBiologyBlood VesselsBypassCarbohydratesCardiovascular DiseasesCell ProliferationCell physiologyCellsCellular biologyCessation of lifeChemistryCountryDevelopmentDigestionDiseaseDrug Delivery SystemsDyesEnzymesExhibitsFailureFunctional disorderFutureGenerationsGoalsHeparitin SulfateHomeostasisHumanHuman PathologyHyperplasiaImmunologyImpairmentIndividualInterleukin-2Knockout MiceKnowledgeLabelLaboratoriesLeadLearningLocationLymphocyteMaintenanceMeasuresMissionModelingMorphologyMusOligosaccharidesOperative Surgical ProceduresOrgan TransplantationPathologicPathologyPathway interactionsPhenotypePlayPrevalencePreventionProcessProteoglycanPublic HealthQualifyingReagentRegulationResearchRoleRuptureShapesSmooth Muscle MyocytesSpecimenTestingTherapeuticTherapeutic InterventionTissuesTransplantationUnited StatesVascular DiseasesVeinsVenousWestern BlottingWorkbasedesignheparanasehuman diseasehuman tissuein vivoinhibitor/antagonistinnovationinsightmortalitynovelnovel therapeuticspolysulfated glycosaminoglycanpreventpublic health relevanceresponserestenosistherapeutic developmenttherapy designvascular smooth muscle cell proliferation

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期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Identification of a cytotoxic form of dimeric interleukin-2 in murine tissues.
DOI： 10.1371/journal.pone.0102191
发表时间： 2014
期刊： PloS one
影响因子： 3.7
作者： [Wrenshall LE, Clabaugh SE, Cool DR, Arumugam P, Grunwald WC, Smith DR, Liu GC, Miller JD]
通讯作者： Miller JD
Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase.
DOI： 10.1038/icb.2011.45
发表时间： 2012-02
期刊： IMMUNOLOGY AND CELL BIOLOGY
影响因子： 4
作者： [Miller, John D., Clabaugh, Suzanne E., Smith, Deandra R., Stevens, R. Brian, Wrenshall, Lucile E.]
通讯作者： Wrenshall, Lucile E.
Role of nuclear IL-2Ra in regulation of vascular smooth muscle cell senescence
  • 批准号：
    10399611
  • 项目类别：
  • 资助金额：
    $7.5万
  • 财政年份：
    2021
  • 负责人：
    Lucile E Wrenshall
  • 依托单位：
    WRIGHT STATE UNIVERSITY
Role of nuclear IL-2Ra in regulation of vascular smooth muscle cell senescence
  • 批准号：
    10226641
  • 项目类别：
  • 资助金额：
    $7.5万
  • 财政年份：
    2021
  • 负责人：
    Lucile E Wrenshall
  • 依托单位：
    WRIGHT STATE UNIVERSITY
The Role of Interleukin-2 in Vascular Smooth Muscle Cell Homeostasis
The Role of Interleukin-2 in Vascular Smooth Muscle Cell Homeostasis
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