Significance of an novel germline AR mutation in black men with prostate cancer

患有前列腺癌的黑人男性中一种新的种系 AR 突变的意义

• 批准号: 8367933
• 负责人: SHAHRIAR KOOCHEKPOUR
• 金额: $ 11.52万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-02 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8367933
• 关键词: Affect; Affinity; African American; Age; Agonist; Alleles; Androgen Antagonists; Androgen Receptor; Androgen Response Element; Androgens; Archives; Base Sequence; Benign; Binding; Biologic Characteristic; Biological; Biological Assay; Cancer Patient; Caucasians; Caucasoid Race; Cell Line; Cell model; Cells; Characteristics; Codon Nucleotides; DNA Binding; DNA Binding Domain; Data; Detection; Development; Diagnosis; Diagnostic; Epithelial Cells; Ethnic Origin; Family; Frequencies; Functional disorder; Future; Gene Expression; Gene Targeting; Generations; Genes; Genetic; Genetic Polymorphism; Genomics; Genotype; Growth; Health; Hormones; In Vitro; Incidence; Individual; Inherited; Laboratories; Length; Ligands; Linkage Disequilibrium; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of prostate; Methods; Missense Mutation; Molecular; Mutation; Neoplasms; Nuclear; Oligonucleotides; Patients; Pattern; Phenotype; Population; Population Attributable Risks; Positioning Attribute; Predisposition; Prostate; Prostate-Specific Antigen; Race; Recording of previous events; Relative (related person); Reporter Genes; Research; Research Personnel; Risk; Risk Assessment; Risk Factors; Role; Signal Transduction; Single Nucleotide Polymorphism; Site-Directed Mutagenesis; Staging; Susceptibility Gene; System; Testing; Time; Tissues; Transactivation; Transfection; Variant; base; cancer cell; cell type; cohort; combinatorial; deprivation; design; disorder risk; ethnic difference; genome wide association study; high risk; interest; male; member; men; mortality; mutant; novel; promoter; prostate carcinogenesis; protein expression; racial difference; receptor; receptor expression; response; restriction enzyme; steroid hormone; tumor progression

项目成果

Regulators of gene expression as biomarkers for prostate cancer.

• 发表时间: 2012
• 期刊: American journal of cancer research
• 影响因子: 5.3
• 作者: S. Willard;S. Koochekpour

Androgen receptor mutations and polymorphisms in African American prostate cancer.

• DOI: 10.7150/ijbs.8974
• 发表时间: 2014
• 期刊: International journal of biological sciences
• 影响因子: 9.2
• 作者: Koochekpour S;Buckles E;Shourideh M;Hu S;Chandra D;Zabaleta J;Attwood K
• 通讯作者: Attwood K