Is CYP11A1 critical for the vitamin D photoprotective system in skin?

阳光会造成DNA损伤。如果修复不当，这种损伤会产生皮肤癌。皮肤中的维生素D系统有助于防止这种皮肤损伤，但所涉及的维生素D化合物及其工作原理尚不清楚。最近的数据显示，新的维生素D化合物具有光保护活性，维生素D化合物增加了DNA修复蛋白的表达。这些研究可能使药理学增强保护免受阳光照射。

Sunlight produces DNA damage. When inadequately repaired, this damage produces skin cancer. The vitamin D system in skin helps protect against this skin damage, but the vitamin D compounds involved and how they work is unclear. Recent data shows new vitamin D compounds with photoprotective activity and that vitamin D compounds increased expression of DNA repair proteins. These studies may enable pharmacological enhancement of protection from sunlight.