Is CYP11A1 critical for the vitamin D photoprotective system in skin?

CYP11A1 对于皮肤中的维生素 D 光保护系统至关重要吗？

• 批准号: nhmrc : 1070688
• 负责人: A/Pr Robert Tuckey
• 金额: $ 34.51万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cyp11a1-critical-vitamin-photoprotective-skin/455438
• 关键词: CYP11A1; critical; vitamin; photoprotective; system

Sunlight produces DNA damage. When inadequately repaired, this damage produces skin cancer. The vitamin D system in skin helps protect against this skin damage, but the vitamin D compounds involved and how they work is unclear. Recent data shows new vitamin D compounds with photoprotective activity and that vitamin D compounds increased expression of DNA repair proteins. These studies may enable pharmacological enhancement of protection from sunlight.

阳光会造成DNA损伤。如果修复不当，这种损伤会产生皮肤癌。皮肤中的维生素D系统有助于防止这种皮肤损伤，但所涉及的维生素D化合物及其工作原理尚不清楚。最近的数据显示，新的维生素D化合物具有光保护活性，维生素D化合物增加了DNA修复蛋白的表达。这些研究可能能够通过药理学增强对阳光的保护。