A Structural & Functional Study of the Upper Airway in Adolescent Girls with PCOS

结构性

• 批准号: 8318692
• 负责人: Raanan Arens
• 金额: $ 99.4万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-17 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318692
• 关键词: Abdomen; Accounting; Adolescence; Adolescent; Adult; Affect; Age; Androgens; Anovulation; Apnea; Architecture; Area; Biochemical; Body Composition; Body fat; Body mass index; Cardiovascular system; Central obesity; Child; Clinical; Communities; Computer software; Continuous Positive Airway Pressure; Data; Databases; Development; Diabetes Mellitus; Diagnosis; Elements; Endocrine System Diseases; Fatty acid glycerol esters; Female Adolescents; Goals; Hour; Hyperlipidemia; Imaging Techniques; Insulin Resistance; Lateral; Lead; Liquid substance; Logistic Regressions; Lymphoid; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Metabolic; Methods; Modeling; Morphology; Muscle; Neck; Neurocognitive Deficit; Non obese; Obesity; Obstruction; Obstructive Sleep Apnea; Oligonucleotides; Overweight; Patients; Phenotype; Physiological; Polycystic Ovary Syndrome; Predictive Value; Prevalence; Process; Property; Regression Analysis; Research; Research Design; Resistance; Resolution; Risk Factors; Scheme; Severities; Shapes; Sleep; Soft Palate; Structure; Symptoms; Tissues; Tongue; Tonsil; Visceral; Wakefulness; Woman; abstracting; aged; awake; base; computerized; girls; indexing; neuromuscular; novel; object motion; pharyngeal critical pressure; pressure; reproductive; respiratory; soft tissue; software systems; subcutaneous; tool; treatment strategy; uvula

DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders associated with overweight and obesity. It affects 5-10% of adolescent girls and women of reproductive age. Diagnosis requires two of the following three symptoms 1) oligo- or anovulation, 2) clinical and/or biochemical signs of excess androgens, or 3) polycystic ovaries. Insulin resistance is a cardinal feature of PCOS given that the majority of women are overweight or obese. Other metabolic derangements including diabetes and hyperlipidemia are also common. PCOS has recently been shown to be associated with obstructive sleep apnea syndrome (OSAS) that may further lead to significant cardiovascular and neurocognitive deficits. However, studies of the mechanisms leading to OSAS in women or adolescent girls with PCOS are lacking. The overarching goal of this proposal is to determine the anatomical and functional risk factors for OSAS in girls with PCOS aged 13-18 years. We will use state-of-the-art techniques for image acquisition, processing and analysis to develop a functional model of the upper airway and surrounding tissues. Such a model will predict the severity of OSAS and enable the development of treatment strategies. We foresee that tools developed in this study will be applied to other phenotypes of OSAS in both children and adults. (End of Abstract)

描述（由申请人提供）：多囊卵巢综合征（PCOS）是与超重和肥胖相关的最常见内分泌疾病之一。它影响 5-10% 的青春期女孩和育龄妇女。诊断需要以下三种症状中的两种：1) 排卵少或无排卵，2) 雄激素过多的临床和/或生化体征，或 3) 多囊卵巢。鉴于大多数女性超重或肥胖，胰岛素抵抗是多囊卵巢综合征的一个主要特征。其他代谢紊乱包括糖尿病和高脂血症也很常见。最近已证明多囊卵巢综合征与阻塞性睡眠呼吸暂停综合征 (OSAS) 相关，后者可能进一步导致严重的心血管和神经认知缺陷。然而，对于患有 PCOS 的女性或少女导致 OSAS 的机制尚缺乏研究。该提案的总体目标是确定 13-18 岁 PCOS 女孩中 OSAS 的解剖学和功能性危险因素。我们将使用最先进的图像采集、处理和分析技术来开发上呼吸道和周围组织的功能模型。这样的模型将预测 OSAS 的严重程度并有助于制定治疗策略。我们预计本研究开发的工具将应用于儿童和成人 OSAS 的其他表型。 （摘要完）