A Structural & Functional Study of the Upper Airway in Adolescent Girls with PCOS

描述（由申请人提供）：多囊卵巢综合征（PCOS）是与超重和肥胖相关的最常见的内分泌疾病之一。它影响到5-10%的青春期女孩和育龄妇女。诊断需要以下三种症状中的两种：1）少排卵或无排卵，2）过量雄激素的临床和/或生化体征，或3）多囊卵巢。胰岛素抵抗是PCOS的主要特征，因为大多数女性超重或肥胖。其他代谢紊乱包括糖尿病和高脂血症也很常见。PCOS最近被证明与阻塞性睡眠呼吸暂停综合征（OSAS）有关，OSAS可能进一步导致显著的心血管和神经认知缺陷。然而，导致OSAS的机制，在妇女或青春期少女PCOS缺乏研究。该提案的总体目标是确定13-18岁PCOS女孩中OSAS的解剖学和功能性风险因素。我们将使用最先进的图像采集、处理和分析技术来开发上气道和周围组织的功能模型。这种模型将预测OSAS的严重程度，并使治疗策略的发展成为可能。我们预见，在这项研究中开发的工具将适用于其他表型的OSAS在儿童和成人。(End摘要）

DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders associated with overweight and obesity. It affects 5-10% of adolescent girls and women of reproductive age. Diagnosis requires two of the following three symptoms 1) oligo- or anovulation, 2) clinical and/or biochemical signs of excess androgens, or 3) polycystic ovaries. Insulin resistance is a cardinal feature of PCOS given that the majority of women are overweight or obese. Other metabolic derangements including diabetes and hyperlipidemia are also common. PCOS has recently been shown to be associated with obstructive sleep apnea syndrome (OSAS) that may further lead to significant cardiovascular and neurocognitive deficits. However, studies of the mechanisms leading to OSAS in women or adolescent girls with PCOS are lacking. The overarching goal of this proposal is to determine the anatomical and functional risk factors for OSAS in girls with PCOS aged 13-18 years. We will use state-of-the-art techniques for image acquisition, processing and analysis to develop a functional model of the upper airway and surrounding tissues. Such a model will predict the severity of OSAS and enable the development of treatment strategies. We foresee that tools developed in this study will be applied to other phenotypes of OSAS in both children and adults. (End of Abstract)