MESA

台面

• 批准号: 8534630
• 负责人: WENDY POST
• 金额: $ 81.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2013-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534630
• 关键词: Abdomen; Ancillary Study; Ankle; Area; Atherosclerosis; Behavioral; Biological; Cardiac; Cardiovascular Diseases; Characteristics; Clinical; Contracts; Coronary Arteriosclerosis; Data; Data Set; Diabetic Angiopathies; Diabetic Retinopathy; Disease; Ethnic Origin; Event; Family; Funding; Fundus photography; Genetic; Health Status; Laboratories; Macular degeneration; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mentors; Myocardial; Nutritional; Participant; Pathology; Pharmaceutical Preparations; Phenotype; Photography; Policies; Population Heterogeneity; Process; Recruitment Activity; Research; Research Design; Research Personnel; Retinal; Risk Marker; Sampling; Severities; Signs and Symptoms; Systemic disease; Time; Training; Ultrasonography; United States National Institutes of Health; Universities; Ventricular Function; Visit; Visual; Visual Acuity; Visual impairment; Woman; Work; X-Ray Computed Tomography; aged; base; brachial artery; cohort; data sharing; design; digital; follow-up; imaging modality; indexing; interest; member; men; population based; psychologic; racial/ethnic difference; radial artery; sex; socioeconomics

The Johns Hopkins University serves as one of six Field Centers for the Multi-Ethnic Study of Atherosclerosis (MESA), a study of the correlates, predictors and progression of subclinical cardiovascular disease (CVD) (disease detected non-invasively before it has produced clinical signs and symptoms) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. Six thousand eight hundred and fourteen (6,814) participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tomometry, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, nutritional and environmental characteristics; and genetic factors. Selected components were repeated over three subsequent examinations through 2007. The cohort has been followed for clinical events since baseline to ascertain and characterize new clinical events and other changes in health status, including changes in medications. The four scientific objectives for the period 2008 through 2015 are (1) identify factors related to progression of subclinical to clinical CVD; (2) identify predictors of decline in ventricular function; (3) further understanding of the basis for racial/ethnic difference in CVD; and (4) provide a platform for in-depth ancillary studies of CVD and other areas. All surviving and willing members of the MESA cohort will be followed up during the time period and included in an fifth examination during 2010-2012. The study will support in-depth ancillary studies that are funded outside of the current contracts. These studies will be operationally integrated into the main study, and the data will be shared across both types of studies, per current MESA and NIH data-sharing policies. The study's data will be provided to interested investigators through a defined process that encourages maximum data utilization but that protects participant confidentially. The study will also serve as a training ground for junior investigators, who will work with senior investigators and be provided with access to the MESA data set and guidance on conducting research. The MESA-EYE component (refraction and fundus photography) was integrated into the second MESA visit in which 6235 people participated between September 2002 and December 2003. The aims of the ocular component were to document the presence and severity of retinal microvascular changes (as interpreted from digital retinal photos) indicative of macular degeneration and diabetic retinopathy, as well as to describe their interrelationships with cross-sectional and longitudinal measures of microvascular and macrovascular systemic disease as defined clinically, by imaging modality, or by analysis of biological laboratory measures. The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, determine the degree to which visual impairment could be reduced with better refractive correction, and correlate visual findings with retinal pathology. Analyses of various ocular phenotypes, including retinal microvascular disease in MESA Family's ancillary study.

约翰霍普金斯大学是动脉粥样硬化多种族研究（梅萨）的六个现场中心之一，这是一项研究亚临床心血管疾病（CVD）（在产生临床体征和症状之前非侵入性检测到的疾病）的相关性，预测因素和进展，在45-84岁的男性和女性的不同人群样本中，基线时没有临床CVD的证据。在2000-2002年期间，从6个现场中心招募了6，814名参与者，并使用计算机断层扫描、心脏MRI、颈动脉超声、血流介导的肱动脉扩张、桡动脉断层测量、踝肱指数测量和视网膜摄影以及亚组腹主动脉CT、颈动脉MRI、用于测量局部心肌功能的心脏MRI标记;确定和推定的实验室风险标志物;社会经济、心理、行为、营养和环境特征;以及遗传因素。在2007年之前的三次后续检查中重复了选定的组成部分。自基线以来，对该队列进行了临床事件随访，以确定和表征新的临床事件和健康状况的其他变化，包括药物治疗的变化。2008年至2015年期间的四个科学目标是：（1）确定与亚临床至临床CVD进展相关的因素;（2）确定心室功能下降的预测因素;（3）进一步了解CVD种族/民族差异的基础;（4）为CVD和其他领域的深入辅助研究提供平台。在此期间，将对梅萨队列中所有幸存和愿意参加的成员进行随访，并将其纳入2010-2012年期间的第五次检查。这项研究将支持在现有合同之外供资的深入辅助研究。这些研究将在操作上整合到主要研究中，根据当前的梅萨和NIH数据共享政策，数据将在两种类型的研究中共享。研究数据将通过一个明确的过程提供给感兴趣的研究者，该过程鼓励最大限度地利用数据，但对参与者进行保密。该研究还将作为初级研究人员的培训基地，他们将与高级研究人员合作，并获得梅萨数据集和开展研究的指导。 MESA-EYE组件（屈光和眼底照相）被集成到第二台面访问，其中6235人参加了2002年9月至2003年12月。眼部部分的目的是记录指示黄斑变性和糖尿病性视网膜病变的视网膜微血管变化（根据数字视网膜照片解释）的存在和严重程度，以及描述其与临床定义的微血管和大血管系统性疾病的横截面和纵向测量的相互关系，通过成像方式或通过生物实验室测量的分析。视力/客观屈光组成部分的设计，使我们能够估计性别和种族的视力损害，确定视力损害的程度可以减少更好的屈光矫正，并与视网膜病理的视觉结果。各种眼部表型的分析，包括梅萨家族辅助研究中的视网膜微血管疾病。