TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.

动脉粥样硬化的多种族研究（梅萨）是一项研究相关因素，预测因素， 亚临床心血管疾病（CVD）在不同人群样本中的进展 年龄在45-84岁的女性，基线时没有临床CVD的证据。在初始融资期间 2000-2002年期间，从六个外地中心招募了6 814名参与者， 检查亚临床冠状动脉粥样硬化的证据，使用计算机断层扫描，心脏 磁共振成像，颈动脉超声，血流介导的肱动脉扩张，桡动脉张力计，踝肱动脉 指数测量和视网膜照相。其他一些变量包括腹主动脉 用于测量局部心肌功能的CT、颈动脉MRI、心脏MRI标记;建立和 假定的实验室风险标志物;社会经济、心理、行为和环境 特征;并且在梅萨群组的子集中评估遗传变异。考试 在随后的五次检查中重复选定的成分， 年，并且自基线以来一直持续随访该队列的临床CVD事件 考试 本提案是针对NHLBI RFP（编号75 N92018 R 0078，多种族研究， 运动疗法中心），旨在继续跟踪和检查梅萨 参与者努力实现以下科学目标：1）提高统计能力， 对临床结局的预测因素进行分析，特别是在信息亚组中; 2）研究 亚临床到临床CVD的进展;和3）确定新的风险因素或因素之间的相互作用 疾病病理生理学的信息。此外，还将实现以下业务目标：1） 继续队列随访和信息收集，以记录临床事件; 2）继续培养 科学合作; 3）对梅萨参与者进行有限的临床检查， 辅助研究检查组件的平台。 该研究将继续支持NHLBI以外资助的深入辅助研究 合同这些研究将在操作上纳入主要研究，数据将共享 根据目前的梅萨和NIH数据共享政策，在整个“梅萨套件”研究中。的 研究的数据将通过一个明确的过程提供给感兴趣的研究者， 最大限度地利用数据，同时保护参与者的机密性。 3

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92018R0078, Multi-Ethnic Study of Atherosclerosis – Field Center) that seeks to continue the follow-up and examination of the MESA participants in an effort to address the following scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. In addition, the following operational goals will be addressed: 1) continue cohort follow-up and information collection to document clinical events; 2) continue to foster scientific collaborations; and 3) conduct a limited clinical examination of the MESA participants as a platform for ancillary study examination components. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality. 3