Facility Core C. Analytical Instrumentation
Facility Core C. Analytical Instrumentation
批准号:
8250003
负责人:
Maria D Person
金额:
$23.52万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-04-01 至 2013-09-30
关键词:
Biological AssayBiological MarkersChemicalsConsultationsCore FacilityDetectionDevelopmentDiseaseEnvironmental Risk FactorFosteringFundingGoalsHealth SciencesImprove AccessLaboratoriesMass Spectrum AnalysisModificationMolecular BiologyMolecular ProfilingNutrientPharmaceutical PreparationsPreventionProcessProteinsProteomicsResearchResearch PersonnelResourcesRoleSamplingSerumServicesTechnical ExpertiseTissuesTrainingTranslational ResearchWorkXenobioticsanalytical methodhuman diseaseimprovedinstrumentationinterestmembermetabolomicsnew technologynovelprotein expression
中文摘要
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英文摘要
Overall Objectives and Specific Aims
The purpose of the Analytical Instrumentation Facility Core is to support Center investigators in the detection,
characterization, and quantification of chemicals and biomolecules.
The specific aims of Facility Core 2 are:
1. To provide sensitive protein identification and modification analyses;
2. To offer services for the identification and quantification of metabolites, nutrients, xenobiotics, and
various types of macromolecular damage;
3. To implement novel analytical methods and improve the sensitivity and throughput of existing
analyses;
4. To provide consultation on the selection and implementation of analytical methods and training
opportunities in usage and applications of analytical instrumentation;
5. To develop tissue and biofluid analytical assays relevant to translational research in coordination
with the Integrated Health Sciences Facility Core;
6. To foster partnerships for improved access to high end analytical instrumentation and technical
expertise in support of Center research.
The Analytical Facility Core will provide sophisticated mass spectrometry resources and expertise to support
Center Investigator research efforts. It will neither unnecessarily duplicate analytical capabilities of
investigators' laboratories nor become a processing center for large numbers of routine analyses. The goals of
the Core have changed slightly during the past funding period to reflect developments in the fields of
proteomics, metabolomics and biomarker identification, and the increased interest in these new technologies
by Center Members. Acquisition of major new instrumentation has enabled significant improvements in
existing services as well as expansion into novel assays applied to protein, drug and metabolite analyses. The
facility has worked in close cooperation with the Molecular Biology Facility Core to integrate services required
for protein expression profiling projects and analysis of serum samples. We anticipate a similar degree of
cooperation with the proposed Integrative Health Science Facility Core which will utilize assays developed for
analysis of tissue and biofluid samples to investigate the role of environmental factors in human disease.
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Facility Core C. Analytical Instrumentation
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批准号:7239195
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项目类别:
-
资助金额:$19.61万
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财政年份:2007
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负责人:Maria D Person
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依托单位:
Facility Core C. Analytical Instrumentation
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批准号:7600470
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项目类别:
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资助金额:$23.19万
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财政年份:--
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负责人:Maria D Person
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依托单位:
Facility Core C. Analytical Instrumentation
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批准号:8055911
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项目类别:
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资助金额:$23.93万
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财政年份:--
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负责人:Maria D Person
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依托单位:
Facility Core C. Analytical Instrumentation
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批准号:7799107
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项目类别:
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资助金额:$23.51万
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财政年份:--
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负责人:Maria D Person
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依托单位:
海外基金