The University of Michigan George M O'Brien Renal Core Center

总体描述（由申请人提供）： 乔治M的焦点。奥布莱恩肾脏中心一直是基础科学研究，已经非常成功地定义了肾脏结构，功能和疾病机制。新技术现在提供了机会，可以以以前无法想象的方式将这些显着的基础科学进步转化为临床。在鉴定遗传易感性方面的进展以及基因组计划和系统生物学技术的出现为开发分子图谱奠定了基础，这些图谱可以叠加在传统的病理和功能描述符上，以便以新的方式定义疾病。这些发展对分子标记物的定义具有重要意义，这些分子标记物将允许准确的个体化预测结果和对治疗的反应，以及识别治疗攻击的关键途径。密歇根大学已经开发并招募了专业人员，以帮助肾病患者利用这些机会。这些机会的实现需要全世界研究人员之间的合作，以便从具有良好特征的个人和群体中收集样本，应用促进信息可用性和交换的技术，开发和维护数据库，以及将这些技术整合到人类疾病、动物模型、细胞系统和分子信号传导，以确定驱动肾脏疾病过程的关键途径。为了实现这些目标，密歇根大学的奥布莱恩肾脏研究核心中心将支持四个核心：一个应用系统生物学核心，已经开发了必要的平台和基础设施，以服务于上述综合功能; B。临床表型分析和生物库核心，将从受影响的特征化个体收集生物样本;应用遗传学核心，将进行基因型/表型匹配的突变分析;和D.一个基础研究增强核心，将促进基础科学的发展，整合和翻译。这些核心与行政核心中的试点和可行性项目以及教育增强计划一起，将协调赠款，利用核心，吸引和支持新的人才进入肾脏研究。密歇根大学将为该中心提供1，000，000美元的补充支持。其目的是建立一个结构，将服务于当地和国家肾脏研究人员和整个肾脏社区。使用基于网络的工具，我们将提供疾病特异性分子病理学的新认识的基础，可供全球公共和私营部门的每一位肾脏研究者使用。

DESCRIPTION, OVERALL (provided by applicant): The focus for the George M. O'Brien Kidney Centers has been basic science investigation that has very successfully defined kidney structure, function and disease mechanisms. New technologies now provide opportunities to translate these remarkable basic science advances to the clinic in ways not previously imaginable. Advances in identification of genetic susceptibilities as well as the advent of the genome project and systems biology technologies set the stage for development of molecular maps that can be superimposed on traditional pathologic and functional descriptors so as to define diseases in a new way. These developments have important implications for definition of molecular markers that will allow accurate individualized prediction of outcome and response to therapy, and the identification of key pathways for therapeutic attack. The University of Michigan has developed and recruited expertise to help exploit these opportunities for people with kidney diseases. The realization of these opportunities requires collaborations between investigators world-wide for the collection of samples from well characterized individuals and populations, the application of technologies that facilitate information availability and exchange, the development and maintenance of databanks, and the integration of these technologies between human diseases, animals models, cellular systems and molecular signaling so as to define key pathways driving renal disease processes. Towards these goals the O'Brien Kidney Research Core Center at the University of Michigan will support four Cores: A. An Applied Systems Biology Core that has developed the platforms and infrastructure necessary to serve the integrative functions outlined above; B. A Clinical Phenotyping and Biobank Core that will collect the biosamples from affected characterized individuals; C. An Applied Genetics Core that will perform mutational analysis for genotype/phenotype matching; and D. A Basic Research Enhancement Core that will facilitate basic science development, integration and translation. These cores together with the Pilot and Feasibility Projects and Educational Enhancement Program in the Administrative Core will coordinate the grant, utilize the Cores and attract and support new talent into kidney research. The University of Michigan will provide $1,000,000 in supplemental support for the Center. The aim is to develop a structure which will serve local and national kidney investigators and the kidney community at large. Using web based tools, we will provide the basis for new understanding of disease-specific molecular pathology that can be used by every kidney investigator in the public and private sector world-wide.