The University of Michigan George M O'Brien Renal Core Center

总体描述(由申请人提供)： 乔治·M·奥布莱恩肾脏中心的重点一直是基础科学研究，这些研究非常成功地确定了肾脏的结构、功能和疾病机制。新技术现在提供了机会，以以前无法想象的方式将这些非凡的基础科学进步转化为临床。遗传易感性鉴定的进展以及基因组计划和系统生物技术的出现为分子图谱的开发奠定了基础，这些分子图谱可以叠加在传统的病理和功能描述符上，从而以一种新的方式定义疾病。这些进展对分子标志物的定义具有重要意义，分子标志物将能够准确地个体化预测结果和治疗反应，并识别治疗发作的关键途径。密歇根大学已经开发和招募了专业知识，以帮助肾脏疾病患者利用这些机会。要实现这些机会，需要世界各地的研究人员合作，从具有良好特征的个人和人群中收集样本，应用促进信息可获得性和交换的技术，开发和维护数据库，并将这些技术整合到人类疾病、动物模型、细胞系统和分子信号之间，以确定推动肾脏疾病过程的关键途径。为了实现这些目标，密歇根大学奥布莱恩肾脏研究核心中心将支持四个核心：a.开发了提供上述综合功能所需平台和基础设施的应用系统生物学核心；b.收集受影响特征个体的生物样本的临床表型鉴定和生物库核心；c.将对基因/表型匹配进行突变分析的应用遗传学核心；以及d.促进基础科学发展、整合和翻译的基础研究增强核心。这些核心与行政核心中的试点和可行性项目以及教育增强计划一起，将协调拨款，利用核心，并吸引和支持新的人才进入肾脏研究。密歇根大学将为该中心提供100万美元的补充支持。其目的是建立一个将为地方和国家肾脏研究人员以及整个肾脏社区服务的结构。使用基于网络的工具，我们将为新理解疾病特定的分子病理学提供基础，世界各地的公共和私营部门的每一位肾脏研究人员都可以使用这些基础。

DESCRIPTION, OVERALL (provided by applicant): The focus for the George M. O'Brien Kidney Centers has been basic science investigation that has very successfully defined kidney structure, function and disease mechanisms. New technologies now provide opportunities to translate these remarkable basic science advances to the clinic in ways not previously imaginable. Advances in identification of genetic susceptibilities as well as the advent of the genome project and systems biology technologies set the stage for development of molecular maps that can be superimposed on traditional pathologic and functional descriptors so as to define diseases in a new way. These developments have important implications for definition of molecular markers that will allow accurate individualized prediction of outcome and response to therapy, and the identification of key pathways for therapeutic attack. The University of Michigan has developed and recruited expertise to help exploit these opportunities for people with kidney diseases. The realization of these opportunities requires collaborations between investigators world-wide for the collection of samples from well characterized individuals and populations, the application of technologies that facilitate information availability and exchange, the development and maintenance of databanks, and the integration of these technologies between human diseases, animals models, cellular systems and molecular signaling so as to define key pathways driving renal disease processes. Towards these goals the O'Brien Kidney Research Core Center at the University of Michigan will support four Cores: A. An Applied Systems Biology Core that has developed the platforms and infrastructure necessary to serve the integrative functions outlined above; B. A Clinical Phenotyping and Biobank Core that will collect the biosamples from affected characterized individuals; C. An Applied Genetics Core that will perform mutational analysis for genotype/phenotype matching; and D. A Basic Research Enhancement Core that will facilitate basic science development, integration and translation. These cores together with the Pilot and Feasibility Projects and Educational Enhancement Program in the Administrative Core will coordinate the grant, utilize the Cores and attract and support new talent into kidney research. The University of Michigan will provide $1,000,000 in supplemental support for the Center. The aim is to develop a structure which will serve local and national kidney investigators and the kidney community at large. Using web based tools, we will provide the basis for new understanding of disease-specific molecular pathology that can be used by every kidney investigator in the public and private sector world-wide.