University of Michigan O'Brien Kidney translational Core Center

George M. O'Brien肾脏中心的重点是基础科学研究已经非常成功地定义了肾脏的结构，功能和疾病机制。现在的新技术提供了机会，以以前无法想象的方式将这些显著的基础科学进步转化为临床。遗传易感性鉴定的进展以及基因组计划和系统生物学技术的出现为分子图谱的发展奠定了基础，这些图谱可以叠加在传统的病理和功能描述符上，从而以一种新的方式定义疾病。这些发展对分子标记的定义具有重要意义，这将允许对治疗结果和治疗反应进行准确的个性化预测，并确定治疗发作的关键途径。密歇根大学已经开发并招募了专业知识来帮助肾病患者利用这些机会。实现这些机会需要全世界研究人员之间的合作，从特征明确的个人和群体中收集样本，应用促进信息可用性和交换的技术，开发和维护数据库，以及将这些技术整合到人类疾病、动物模型、细胞系统和分子信号之间，以确定驱动肾脏疾病过程的关键途径。为了实现这些目标，密歇根大学的奥布莱恩肾脏研究核心中心将支持四个核心：A.应用系统生物学核心，该核心开发了服务上述综合功能所需的平台和基础设施；B.临床表型和生物库核心，将从受影响的特征个体收集生物样本；C.应用遗传学核心（Applied Genetics Core），将对基因型/表型匹配进行突变分析；D.促进基础科学发展、整合和转化的基础研究增强核心。这些核心与行政核心中的试点和可行性项目以及教育增强计划将协调拨款，利用核心并吸引和支持新的人才参与肾脏研究。密歇根大学将为该中心提供100万美元的补充支持。目的是建立一个结构，将服务于地方和国家的肾脏研究者和肾脏社区在大。使用基于网络的工具，我们将为疾病特异性分子病理学的新理解提供基础，这可以被全世界公共和私营部门的每个肾脏研究者使用。

The focus for the George M. O'Brien Kidney Centers has been basic science investigation that has very successfully defined kidney structure, function and disease mechanisms. New technologies now provide opportunities to translate these remarkable basic science advances to the clinic in ways not previously imaginable. Advances in identification of genetic susceptibilities as well as the advent of the genome project and systems biology technologies set the stage for development of molecular maps that can be superimposed on traditional pathologic and functional descriptors so as to define diseases in a new way. These developments have important implications for definition of molecular markers that will allow accurate individualized prediction of outcome and response to therapy, and the identification of key pathways for therapeutic attack. The University of Michigan has developed and recruited expertise to help exploit these opportunities for people with kidney diseases. The realization of these opportunities requires collaborations between investigators world-wide for the collection of samples from well characterized individuals and populations, the application of technologies that facilitate information availability and exchange, the development and maintenance of databanks, and the integration of these technologies between human diseases, animals models, cellular systems and molecular signaling so as to define key pathways driving renal disease processes. Towards these goals the O'Brien Kidney Research Core Center at the University of Michigan will support four Cores: A. An Applied Systems Biology Core that has developed the platforms and infrastructure necessary to serve the integrative functions outlined above; B. A Clinical Phenotyping and Biobank Core that will collect the biosamples from affected characterized individuals; and C. An Applied Genetics Core that will perform mutational analysis for genotype/phenotype matching; D. A Basic Research Enhancement Core that will facilitate basic science development, integration and translation. These cores together with the Pilot and Feasibility Projects and Educational Enhancement Program in the Administrative Core will coordinate the grant, utilize the Cores and attract and support new talent into kidney research. The University of Michigan will provide $1,000,000 in supplemental support for the Center. The aim is to develop a structure which will serve local and national kidney investigators and the kidney community at large. Using web based tools, we will provide the basis for new understanding of disease-specific molecular pathology that can be used by every kidney investigator in the public and private sector world-wide.