Administrative Core

行政核心

基本信息

批准号：
8259227
负责人：
HAROLD FISHER DVORAK
金额：
$ 10.3万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-06-13 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8259227
关键词：
Address Advisory Committees Anatomy Animal Model Appointment Area Biochemistry Bone Marrow Cells Budgets Cellular biology Clinical Collaborations Commit Communication Consensus Consumption Data Decision Making Development Documentation Elements Ensure Epithelial-Stromal Communication Estrogen Receptors Estrogens Event Expenditure Faculty Funding Future Goals Grant Guidelines Human Resources Individual Inflammation Institution Investigation Leadership Maintenance Malignant Neoplasms Manuscripts Mission Molecular Molecular Biology Monitor Morphology NR4A1 gene Participant Pathogenesis Pathology Pathway interactions Postdoctoral Fellow Preparation Principal Investigator Progress Reports Radiation Oncology Regulation Reporting Research Research Personnel Resource Allocation Resources Schedule Scientist Series Services Signal Pathway Signaling Molecule Talents Technical Expertise Techniques Therapeutic Thrombospondin 1 Time Tissues Training Travel United States National Institutes of Health Universities Vascular Permeabilities Visit Work Writing angiogenesis base cell type combinatorial design improved interest malignant breast neoplasm medical schools meetings member novel operation professor programs success therapeutic target trafficking tumor web site

项目摘要

The Administrative Core will provide organizational and scientific leadership for the program project. The DPG brings together a group of individuals with widely diverse talents and technical expertise (i.e., cell and molecular biology, morphology, pathology, biochemistry, etc.) to focus on the "spatial and temporal regulation of angiogenesis". The overriding hypothesis for the PPG is that the tumor vasculature and other elements of tumor stroma are attractive therapeutic targets. To explore this hypothesis, the Principal investigator has worked with the project and core leaders to develop six central themes: i. Exploration of novel signaling pathways or molecules in angiogenesis. ii. Investigation of signaling pathways that intersect with the TR3/Nur77, PI3K/Akt, estrogen-estrogen receptor, and thrombospondin-1 pathways, iii. Mobilization and trafficking of bone marrow cells and their accumulation in tumor stroma. iv. Understanding the ultrastructural components and the molecular mechanisms that regulate vascular permeability, v. Investigations into the molecular basis of therapeutics in development of cancer, vi. Combinatorial therapeutic approaches to improve tumortherapy. The Administrative Core will manage the financial resources, facilitate communication between participants and make decisions regarding the scientific direction of the project. Drs. Dvorak and Lawler will make the final decisions regarding the allocation of resources and funds, the progress of the individual projects and the operation of the cores. They will address all issues that arise regarding changes in the various investigators' efforts or institutional affiliation. The opinions of the Executive Committee, the External Advisory Board and the Clinical Advisory Board will be carefully weighed in making these decisions. Facilitation of communication among the projects and core leaders is a key mission of the Administrative Core. It will organize, coordinate and document scientific and administrative meetings of the participants. These will include monthly meetings of the project leaders, core leaders, and postdoctoral and technical personnel who are involved in the project. These meetings will include a period of time for informal interactions, a presentation by an individual involved in one of the projects and a discussion period. The Administrative Core will also organize retreats (every 12 to 18 months) that will include the External Advisory Board and the Clinical Advisory Boards. The Administrative Core is developing a web site that will further enhance, communication n.y posting, information; regarding, internal and external meetings^ seminars, and data, as: weir as- arrTcfeas^section where anyorTefrrtrte-PFGcarrpasfa^qaestfanrarrraver'rTypxitrtesrEr.

行政核心将为该计划项目提供组织和科学领导。这 DPG汇集了一群具有广泛多样性和技术专业知识（即细胞和细胞和技术专长）的个人分子生物学，形态学，病理学，生物化学等）专注于“空间和时间” 血管生成的调节。肿瘤基质的元素是有吸引力的治疗靶标。为了探索这一假设，校长调查人员与该项目和核心领导者合作开发了六个中心主题：i。探索新型信号通路或血管生成中的分子。 ii。相交的信号通路的研究与TR3/NUR77，PI3K/AKT，雌激素雌激素受体和血小板素-1途径，III。动员骨髓细胞的运输及其在肿瘤基质中的积累。 iv。了解超微结构成分和调节血管通透性的分子机制，v。研究癌症发展中治疗剂的分子基础，VI。组合改善肿瘤疗法的治疗方法。行政核心将管理财务资源，促进参与者并就该项目的科学方向做出决定。博士。 Dvorak和Lawler将就资源和资金分配，个人进步做出最终决定项目和核心的操作。他们将解决有关变更的所有问题各种调查人员的努力或机构隶属关系。执行委员会的意见，外部顾问委员会和临床咨询委员会将在做出这些决定时仔细权衡。促进项目和核心领导者之间的沟通是行政的关键任务核。它将组织，协调和记录参与者的科学和行政会议。这些将包括项目负责人，核心领导者以及博士后和技术的每月会议参与该项目的人员。这些会议将包括非正式的一段时间互动，参与其中一个项目的个人的演讲和讨论期。这行政核心还将组织务虚会（每12到18个月），其中包括外部咨询董事会和临床咨询委员会。管理核心正在开发一个网站，该网站将进一步增强，沟通纽约发布，信息；关于内部和外部会议^研讨会，以及数据，AS：Weir as-arrtcfeas^部分，其中anyortefrrtrte-pfgcarrpasfa^qaestfanrrraver'rtypxitrtesrer。