Administrative Core

行政核心将为该计划项目提供组织和科学领导。的 DPG汇集了一群具有广泛多样的人才和技术专长的个人（即，细胞和 分子生物学、形态学、病理学、生物化学等）专注于“空间和时间 血管生成的调节”。PPG的首要假设是肿瘤血管系统和其他 肿瘤基质的成分是有吸引力的治疗靶点。为了探索这一假设，校长 调查员与项目和核心领导人合作，制定了六个中心主题：探索 血管生成中的新信号通路或分子。二.交叉信号通路的研究 与TR 3/Nur 77、PI 3 K/Akt、雌激素-雌激素受体和血小板反应蛋白-1途径，iii.动员 以及骨髓细胞的运输和它们在肿瘤基质中的积累。四.了解 超微结构组分和调节血管通透性的分子机制，v. 癌症发展中治疗学的分子基础研究。组合 治疗方法来改善肿瘤治疗。 行政核心将管理财政资源，促进 参与者，并就项目的科学方向作出决定。德沃夏克医生和劳勒医生 作出有关资源和资金分配的最终决定，个人的进步， 项目和核心业务。他们将解决所有有关变化的问题， 各种调查人员的努力或机构隶属关系。执行委员会、外部 咨询委员会和临床咨询委员会将在作出这些决定时仔细权衡。 促进项目和核心领导人之间的沟通是行政协调会的一项重要使命。 核心它将组织、协调和记录与会者的科学和行政会议。 这些将包括项目负责人，核心领导人，博士后和技术人员的每月会议 参与该项目的人员。这些会议将包括一段时间的非正式会议， 互动，一个参与其中一个项目的个人的陈述和一个讨论期。的 行政核心还将组织务虚会（每12至18个月），其中将包括外部咨询 委员会和临床咨询委员会。行政核心正在开发一个网站， 加强，沟通，张贴，信息;关于，内部和外部会议，研讨会，和 数据，如：weir as- arrTcfeas^section，其中任何Teffrtrte-PFGcarrpasfa ^qaestfanrarraver 'rTypxitrtesrEr。

The Administrative Core will provide organizational and scientific leadership for the program project. The DPG brings together a group of individuals with widely diverse talents and technical expertise (i.e., cell and molecular biology, morphology, pathology, biochemistry, etc.) to focus on the "spatial and temporal regulation of angiogenesis". The overriding hypothesis for the PPG is that the tumor vasculature and other elements of tumor stroma are attractive therapeutic targets. To explore this hypothesis, the Principal investigator has worked with the project and core leaders to develop six central themes: i. Exploration of novel signaling pathways or molecules in angiogenesis. ii. Investigation of signaling pathways that intersect with the TR3/Nur77, PI3K/Akt, estrogen-estrogen receptor, and thrombospondin-1 pathways, iii. Mobilization and trafficking of bone marrow cells and their accumulation in tumor stroma. iv. Understanding the ultrastructural components and the molecular mechanisms that regulate vascular permeability, v. Investigations into the molecular basis of therapeutics in development of cancer, vi. Combinatorial therapeutic approaches to improve tumortherapy. The Administrative Core will manage the financial resources, facilitate communication between participants and make decisions regarding the scientific direction of the project. Drs. Dvorak and Lawler will make the final decisions regarding the allocation of resources and funds, the progress of the individual projects and the operation of the cores. They will address all issues that arise regarding changes in the various investigators' efforts or institutional affiliation. The opinions of the Executive Committee, the External Advisory Board and the Clinical Advisory Board will be carefully weighed in making these decisions. Facilitation of communication among the projects and core leaders is a key mission of the Administrative Core. It will organize, coordinate and document scientific and administrative meetings of the participants. These will include monthly meetings of the project leaders, core leaders, and postdoctoral and technical personnel who are involved in the project. These meetings will include a period of time for informal interactions, a presentation by an individual involved in one of the projects and a discussion period. The Administrative Core will also organize retreats (every 12 to 18 months) that will include the External Advisory Board and the Clinical Advisory Boards. The Administrative Core is developing a web site that will further enhance, communication n.y posting, information; regarding, internal and external meetings^ seminars, and data, as: weir as- arrTcfeas^section where anyorTefrrtrte-PFGcarrpasfa^qaestfanrarrraver'rTypxitrtesrEr.