PRIMATE NEURO-IMAGING OF CENTRAL NERVOUS SYSTEM DRUG DELIVERY DEVICE

该子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心赠款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 为子项目列出的总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的主要目标是优化和证明加压嗅觉递送（POD）装置的有效性，该装置将提供对大脑和中枢神经系统（CNS）的最佳药物暴露。 通过在非人灵长类动物（NHP）中使用高灵敏度正电子发射断层扫描（PET）成像研究，我们将优化嗅觉界面处气溶胶沉积分数的设备性能，并证明嗅觉优化设备将药物递送到大脑和CNS中的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primary goal of this research is to optimize and demonstrate the effectiveness of the pressurized olfactory delivery (POD) device that will provide optimal drug exposure to the brain and the central nervous system (CNS). Through the use of highly sensitive positron emission tomography (PET) imaging study in non-human primates (NHP), we will optimize the device performance in the fraction of aerosol deposition at the olfactory interface and demonstrate the ability of the olfactory optimized device to deliver drugs into the brain and the CNS.