PRIMATE NEURO-IMAGING OF CENTRAL NERVOUS SYSTEM DRUG DELIVERY DEVICE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项研究的主要目标是优化和证明加压嗅觉输送(POD)设备的有效性，该设备将提供最佳的药物暴露于大脑和中枢神经系统(CNS)。通过在非人类灵长类动物(NHP)中使用高灵敏度的正电子发射断层扫描(PET)成像研究，我们将优化设备在嗅觉界面气溶胶沉积分数方面的性能，并展示嗅觉优化设备将药物输送到大脑和中枢神经系统的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primary goal of this research is to optimize and demonstrate the effectiveness of the pressurized olfactory delivery (POD) device that will provide optimal drug exposure to the brain and the central nervous system (CNS). Through the use of highly sensitive positron emission tomography (PET) imaging study in non-human primates (NHP), we will optimize the device performance in the fraction of aerosol deposition at the olfactory interface and demonstrate the ability of the olfactory optimized device to deliver drugs into the brain and the CNS.