THERAPEUTIC EFFECTS AND ABUSE OF GABA(A) MODULATORS

GABA(A) 调节剂的治疗效果和滥用

• 批准号: 8357917
• 负责人: JAMES K ROWLETT
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357917
• 关键词: Adverse effects; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Drug Prescriptions; Funding; GABA-A Receptor; Grant; Modern Medicine; Motor; Muscle relaxants; National Center for Research Resources; New England; Performance; Pharmaceutical Preparations; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Sedation procedure; Source; Therapeutic Effect; United States National Institutes of Health; addiction; base; cost; gamma-Aminobutyric Acid; hypnotic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Benzodiazepines (BZs) are prescribed widely as anxiolytics, hypnotics, muscle relaxants, and anticonvulsants. Although BZs are considered to be among the safest prescription drugs in modern medicine, their utility is constrained by a number of side effects, including unwanted sedation, impaired motor performance, and the liability for addiction. This project seeks to identify the GABA(A) receptor subtype mechanisms underlying the clinically beneficial vs. unwanted side effects of BZ-type drugs.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 苯二氮卓类药物（BZ）被广泛用作抗焦虑药、催眠药、肌肉松弛药和抗惊厥药。 虽然BZ被认为是现代医学中最安全的处方药之一，但它们的效用受到许多副作用的限制，包括不必要的镇静，运动性能受损和成瘾的责任。 该项目旨在确定GABA（A）受体亚型机制，这些机制是BZ型药物临床有益的副作用。