IMPACT OF IMMUNE SENESCENCE ON HERPES ZOSTER IN A NONHUMAN PRIMATE MODEL

免疫衰老对非人灵长类动物模型中带状疱疹的影响

基本信息

  • 批准号:
    8357862
  • 负责人:
  • 金额:
    $ 5.82万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Reactivation of latent varicella zoster virus (VZV) leads to herpes zoster (HZ, shingles), which causes major morbidity and sometimes mortality in older individuals. Advanced age is the primary risk factor not only for developing HZ, but also complications such as post herpetic neuralgia. The currently approved vaccine against HZ reduces the incidence of shingles by only 51%. A major obstacle in developing better treatments and vaccines for HZ is that VZV infection of laboratory animals does not result in clinical disease. Consequently, our understanding of the immune correlates of protection against VZV infection and reactivation remains very limited. We have developed a nonhuman primate model wherein young rhesus macaques infected with simian varicella virus (SVV) display the hallmarks of VZV infection in humans. In contrast to young rhesus macaques, aged animals infected with SVV remain persistently viremic despite the development of an IgG antibody response that was comparable to that generated by young animals. On the other hand, SVV-specific T cell responses in aged animals were significantly delayed compared to those generated by young animals. These data strongly suggest that, as described for VZV, defects in T cell responses in aged animals result in poor immunological control of SVV replication. Therefore, SVV infection of young and aged rhesus macaques provides a unique opportunity to: (1) identify age-related differences in the SVV-specific T cell responses and (2) determine how these differences in immune responses affect the aged animal's ability to control SVV replication and to maintain latency.
这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的, 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量, 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 潜伏水痘带状疱疹病毒(VZV)的重新激活导致带状疱疹(HZ,带状疱疹),这导致老年人的主要发病率,有时甚至死亡。高龄不仅是发展HZ的主要危险因素,也是并发症如带状疱疹后神经痛的主要危险因素。目前批准的HZ疫苗仅将带状疱疹的发病率降低了51%。在开发更好的治疗和疫苗HZ的一个主要障碍是,VZV感染的实验室动物不会导致临床疾病。因此,我们对VZV感染和再激活的免疫保护相关性的理解仍然非常有限。我们已经开发了一种非人灵长类动物模型,其中感染猴水痘病毒(SVV)的年轻恒河猴显示出人类VZV感染的标志。与年轻的恒河猴相反,感染SVV的老年动物保持持续的病毒血症,尽管IgG抗体反应的发展与年轻动物产生的相当。另一方面,与年轻动物产生的SVV特异性T细胞应答相比,老年动物中SVV特异性T细胞应答显著延迟。这些数据有力地表明,如对VZV所述,老年动物中T细胞应答的缺陷导致SVV复制的免疫控制不良。因此,年轻和老年恒河猴的SVV感染提供了一个独特的机会:(1)确定SVV特异性T细胞应答中的年龄相关差异和(2)确定这些免疫应答差异如何影响老年动物控制SVV复制和维持潜伏期的能力。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Ilhem Messaoudi其他文献

Ilhem Messaoudi的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Ilhem Messaoudi', 18)}}的其他基金

POPI: Placenta, Opioids and Perinatal Implications
POPI:胎盘、阿片类药物和围产期影响
  • 批准号:
    10748428
  • 财政年份:
    2023
  • 资助金额:
    $ 5.82万
  • 项目类别:
Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10531750
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:
Maternal obesity and neonatal innate immunity
母亲肥胖与新生儿先天免疫
  • 批准号:
    10489886
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:
Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10877234
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:
Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10440492
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:
Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10663851
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:
Mechanisms of varicella virus dissemination
水痘病毒传播机制
  • 批准号:
    10489895
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:
Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10526150
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:
Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10502298
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:
Impact of chronic alcohol consumption on the functional and epigenetic landscapes of monocytes and their progenitors
长期饮酒对单核细胞及其祖细胞功能和表观遗传景观的影响
  • 批准号:
    10616854
  • 财政年份:
    2021
  • 资助金额:
    $ 5.82万
  • 项目类别:

相似海外基金

The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
  • 批准号:
    EP/Z000920/1
  • 财政年份:
    2025
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
  • 批准号:
    FT230100276
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
  • 批准号:
    MR/X024261/1
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
  • 批准号:
    DE240100388
  • 财政年份:
    2024
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
  • 批准号:
    2889694
  • 财政年份:
    2023
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
  • 批准号:
    2842926
  • 财政年份:
    2023
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
  • 批准号:
    NC/X001644/1
  • 财政年份:
    2023
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
  • 批准号:
    2337595
  • 财政年份:
    2023
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
  • 批准号:
    2232190
  • 财政年份:
    2023
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
  • 批准号:
    23K17514
  • 财政年份:
    2023
  • 资助金额:
    $ 5.82万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了