PRODUCTION OF CCL7 BY ASTROCYTES: SIV NEUROINVASION AND AIDS ENCEPHALITIS

星形胶质细胞产生 CCL7:SIV 神经侵袭和艾滋病脑炎

基本信息

  • 批准号:
    8358099
  • 负责人:
  • 金额:
    $ 5.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Monocyte/macrophages and activated lymphocytes traffic through normal brain, and this trafficking is increased in inflammatory conditions such as HIV encephalitis (HIVE). HIVE is characterized in part by perivascular accumulations of macrophages. The earliest events in this process are poorly understood and difficult or impossible to address in humans. The SIV-infected macaque model of neuroAIDS has demonstrated migration of monocytes into the brain early in disease, coincident with peak SIV viremia. The chemotactic signals that initiate the increased emigration of mononuclear cells into the CNS have not been described. Here we describe astrocytes as a source of chemokines to facilitate basal levels of monocyte trafficking to CNS and that increased CCL7 production is probably responsible for initiating the increased trafficking in neuroAIDS. We have previously published complementary in vivo work demonstrating the presence of MCP-3/CCL7 (and other chemokines) within the brain of SIV-infected macaques. Here we demonstrate that MCP-3/CCL7 is a significant chemokine produced by astrocytes, that CCL7 is responsible for basal levels of monocyte recruitment and that production of CCL7 is rapidly increased by TNF and thus likely plays a critical role in initiating neuroinvasion by SIV/HIV.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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科研奖励数量(0)
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专利数量(0)

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ANDREW G MACLEAN其他文献

ANDREW G MACLEAN的其他文献

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{{ truncateString('ANDREW G MACLEAN', 18)}}的其他基金

Reducing the CNS reservoir through myeloid cell depletion
通过耗竭骨髓细胞减少中枢神经系统储库
  • 批准号:
    10452642
  • 财政年份:
    2021
  • 资助金额:
    $ 5.78万
  • 项目类别:
Reducing the CNS reservoir through myeloid cell depletion
通过耗竭骨髓细胞减少中枢神经系统储库
  • 批准号:
    10254688
  • 财政年份:
    2021
  • 资助金额:
    $ 5.78万
  • 项目类别:
Exploratory Research on HIV Contribution to Heart and Lung Comorbidities
HIV 对心肺合并症影响的探索性研究
  • 批准号:
    10012373
  • 财政年份:
    2020
  • 资助金额:
    $ 5.78万
  • 项目类别:
Exploratory Research on HIV Contribution to Heart and Lung Comorbidities
HIV 对心肺合并症影响的探索性研究
  • 批准号:
    10569641
  • 财政年份:
    2020
  • 资助金额:
    $ 5.78万
  • 项目类别:
Exploratory Research on HIV Contribution to Heart and Lung Comorbidities
HIV 对心肺合并症影响的探索性研究
  • 批准号:
    10343825
  • 财政年份:
    2020
  • 资助金额:
    $ 5.78万
  • 项目类别:
S100BETA AS A DETERMINANT FOR DEVELOPMENT OF MONOCYTE-DRIVEN ENCEPHALITIS
S100BETA 作为单核细胞驱动性脑炎发展的决定因素
  • 批准号:
    8358083
  • 财政年份:
    2011
  • 资助金额:
    $ 5.78万
  • 项目类别:
DYMANICS OF ENDOTHELIAL CELL SIGNALING AND SIVE NEUROINFLAMMATION
内皮细胞信号传导和严重神经炎症的动力学
  • 批准号:
    8358124
  • 财政年份:
    2011
  • 资助金额:
    $ 5.78万
  • 项目类别:
INTERMEDIATE FILAMENT EXPRESSION IN ASTROCYTES
星形胶质细胞中的中间丝表达
  • 批准号:
    8358123
  • 财政年份:
    2011
  • 资助金额:
    $ 5.78万
  • 项目类别:
S100BETA, AS A DETERMINANT FOR DEVELOPMENT OF MONOCYTE-DRIVEN ENCEPHALITIS
S100BETA,作为单核细胞驱动性脑炎发展的决定因素
  • 批准号:
    8172980
  • 财政年份:
    2010
  • 资助金额:
    $ 5.78万
  • 项目类别:
FOCAL ADHESION KINASE ACTIVATION IN THE BLOOD-BRAIN BARRIER
血脑屏障中的局部粘附激酶激活
  • 批准号:
    8172964
  • 财政年份:
    2010
  • 资助金额:
    $ 5.78万
  • 项目类别:

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