Biospecimen Shared Resource

项目摘要(见说明)：堪萨斯大学癌症中心(KUCC)已经建立了生物谱库活动，以协调组织和外周血液样本的伦理收集、存储、注释和分发，以支持翻译研究。这一中心范围内的活动由一个跨计划的内部咨询委员会(I AB)监督，该委员会最近在病理学和实验室医学部内由安德鲁·K·戈德温(Andrew K.Godwin)监督。BSR有三个主要功能：1)确定参与者，实施知情同意，从选定的人群中收集组织、血液和/或尿样，并获得用于研究的个人和家族癌症史、临床干预和生活方式因素的信息；2)处理和保存通过研究人员发起的研究获得的人类生物标本；以及3)提供组织样本的专家组织学技术程序和病理评估。受过专门培训的工作人员与病理学家、内科肿瘤学家、外科医生和其他医院工作人员合作，征得患者同意，收集样本，并收集关于每位捐赠者和相应样本的全面临床信息。作为该银行的一部分，BSR工作人员提供：i)出色的诊断病理学支持；ii)患者和参与者的组织、血液和/或尿液用于研究的全面知情同意程序；iii)专门收集和分发标本以支持研究的专门生物检验库；iv)来自每个参与者的临床记录和自我报告的健康史的广泛支持数据；v)固定、石蜡处理、切片准备和常规染色、免疫组织化学支持、组织微阵列、图像分析和数字病理学。所有标本都将链接到由生物统计和信息学共享资源支持的全面临床数据库。BSR目前存放了2,000多例新鲜冷冻组织样本和2,000多例血液样本，并可查阅存档的28,000多例外科病理病例。2010年，BSR在四个项目中为16名KUCC调查人员提供了服务(Q同行评审资助)，包括分发382个新鲜和新鲜冷冻的标本，666个活动单位来支持调查人员发起的研究，以及3105个组织技术服务单位。2010年，47.4%的BSR是由同行评审资助的调查人员使用的。

PROJECT SUMMARY (See instructions): The University of Kansas Cancer Center (KUCC) has established biospecimen banking activities to coordinate the ethical collection, storage, annotation, and distribution of tissue and peripheral blood samples to support translational research. This center-wide activity is overseen by an inter-programmatic Internal Advisory Board (I AB), under the recent supervision of Andrew K. Godwin within the Department of Pathology and Laboratory Medicine. The BSR has three major functions: 1) identify participants, administer informed consent, collect tissue, blood, and/or urine samples from selected populations, and obtain information on personal and family histories of cancer, clinical intervention, and lifestyle factors for use in research; 2) process and house human biospecimens obtained through investigator-initiated studies; and 3) provide expert histology technical procedures and pathological evaluation of tissue samples. Working in collaboration with pathologists, medical oncologists, surgeons and other hospital personnel, specially trained staff obtain patient consent, collect samples and assemble comprehensive clinical information about each donor and the corresponding samples. As part of this banking the BSR staff provides i) outstanding diagnostic pathology support; ii) a comprehensive informed consent process for the use of tissue, blood, and/or urine from patients and participants for research; iii) a specialized biospecimen bank devoted to the collection and distribution of specimens to support research; iv) extensive supporting data from the clinical record and self-reported health history of each participant, and v) fixation, paraffin processing, slide preparation and routine staining, immunohistochemistry support, tissue microarray, image analysis and digital pathology. All specimens will be linked to comprehensive clinical databases supported by the Biostatistics and Informatics Shared Resource. The BSR currently houses over 2,000 cases with fresh-frozen tissue samples and over 2,000 cases with blood samples and has access to over 28,000 surgical pathology cases on file. In 2010 the BSR served 16 (Q peer-reviewed funded) KUCC investigators across the four programs, including distribution of 382 fresh and fresh-frozen specimens, 666 units of activity to support investigator-initiated studies, and 3,105 units of histotechnology services. 47.4% of the BSR's use in 2010 was by peer-reviewed funded investigators.