University of Kansas Cancer Center Midwest Pre-Clinical Imaging Center

堪萨斯大学癌症中心中西部临床前影像中心

• 批准号: 10795272
• 负责人: ROY A. JENSEN
• 金额: $ 800万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-08 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795272
• 关键词: Animal Model; Animals; Basic Science; Cancer Center; Cancer Model; Clinical; Elements; Ensure; Floor; Funding; Future; Health care facility; Health system; Image; Imaging Techniques; Inpatients; Joints; Kansas; Laboratory Animals; Leadership; Longevity; Magnetic Resonance Imaging; Medical center; Midwestern United States; Modernization; Plants; Pre-Clinical Model; Process; Research; Research Activity; Research Project Grants; Techniques; Time; Translational Research; Universities; animal facility; animal imaging; aspirate; imaging capabilities; imaging facilities; mouse model; multimodality; preclinical imaging; serial imaging

Abstract The University of Kansas Medical Center seeks to build a state-of-the-art multi-modality pre-clinical imaging facility as a critical element of a campus-wide master planning process. This facility while serving the entire KUMC campus will also be an important asset for our cancer center as it seeks to expand its efforts in developing and utilizing mouse models of cancer by leveraging cutting edge experimental imaging techniques. The campus master planning effort that has taken place over the past year has focused on achieving better alignment of the capabilities of our physical plant with our basic and translational research aspirations, while simultaneously enabling the future expansion of our inpatient clinical facilities. The animal imaging facility will serve the research needs of the entire medical center campus and will be housed within the barrier of a newly constructed campus-wide vivarium that will occupy the first two floors of a planned cancer center building. This facility will be an important asset for the University and region as we seek to expand, modernize and optimize the use of animal models for preclinical translational research activities. Placement of the facility within the vivarium barrier will allow us to reduce the number of animals necessary for specific research projects by enabling serial imaging capability via a wide variety of techniques that are not possible with our current facilities. The current vivarium is approximately 50 years old, is nearing its useful lifespan, is projected to reach capacity within the next five years, cannot accommodate CT or MRI imaging, and occupies land that is needed for a critically important expansion of our inpatient health care facilities. As a result, this C06 opportunity represents an ideal time to rethink, reimagine, and renew our laboratory animal facilities and ensure that they meet the needs of KUMC in the 21st century. The proposed project is a critical element the new vivarium and in realizing the new campus master plan and will provide tenant fit-out of planned shell space on the University of Kansas Medical Center Campus. Cancer center, University, and Health System leadership have made this building their highest collective priority and ~$150 Million have been raised have been raised thus far to fund the joint facility through philanthropic efforts and three Congressionally directed spending allocations.

摘要 堪萨斯大学医学中心寻求建立一个最先进的多模态临床前成像 作为校园总体规划过程的一个关键要素。这个设施，同时服务于整个 KUMC校园也将成为我们癌症中心的重要资产，因为它寻求扩大其在以下方面的努力： 开发和利用小鼠癌症模型，利用尖端的实验成像技术。 校园总体规划的努力，已经发生在过去的一年里，重点是实现更好的 我们的物理工厂的能力与我们的基础和转化研究的愿望，而 同时使我们的住院临床设施的未来扩展。 动物成像设施将服务于整个医学中心校园的研究需求， 在一个新建的校园范围内的动物园，将占据一个前两层的屏障内， 规划中的癌症中心大楼这一设施将是大学和地区的重要资产，因为我们寻求 扩大，现代化和优化临床前转化研究活动的动物模型的使用。 将设施放置在动物园屏障内将使我们能够减少所需的动物数量， 具体的研究项目，使串行成像能力，通过各种各样的技术， 以我们现有的设施。目前的饲养场大约有50年的历史， 寿命，预计在未来五年内达到容量，不能容纳CT或MRI成像， 并占用了我们住院医疗保健设施至关重要的扩建所需的土地。作为 因此，这个C06的机会代表了一个理想的时间来重新思考，重新想象，并更新我们的实验室动物 设施，并确保他们满足KUMC在21世纪世纪的需要。该项目是一个关键的 元素的新动物园和实现新的校园总体规划，并将提供租户装修， 计划在堪萨斯大学医学中心校园的外壳空间。癌症中心大学 卫生系统领导层已将这座建筑作为他们的最高集体优先事项， 迄今为止，通过慈善努力和三次国会会议， 定向支出分配。